Protein structure, function and regulation
Proteins are essential for executing and controlling all cellular processes. Many human disease states, including cancer, blood disorders such as sickle cell anemia and hemophilia, and neurodegenerative disorders such as Alzheimer’s disease, are associated with defective protein structure and/or function. A greater comprehension of protein structure, function, and regulation is thus central to understanding normal and pathological cellular processes, and improving diagnostic and therapeutic approaches towards a wide array of human and animal diseases. Members of this CMB research focus area use biochemical, biophysical, and computational approaches to study protein function and regulation in diverse cellular processes including cell cycle progression, DNA repair, plant cell wall biosynthesis, and signal transduction.