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Research Archives

RI-INBRE (2004 – 2011)

Collaborative Projects

Implications of DNA Replication Fork Proteins for Cancer (2009-2011)
Investigator: Karen Almeida, Rhode Island College
Collaborator/Mentor: Susan Gerbi, Brown University

Bacterial Glycome as Antibacterial Targets (2011-2014)
Co-Investigators: Christopher Reid & Kirsten Hokeness, Bryant University
Collaborator/Mentor: Amit Basu, Brown University

Fate of Mercury Contaminants in Narragansett Bay, Rhode Island (2009-2012)
Investigator: David Taylor, Roger Williams University
Collaborator/Mentor: Warren Prell, Brown University

Mechanisms of CpG-ODN’s Protection against UV-induced Cell Death (2009-2011)
Investigator: Yinsheng Wan, Providence College
Collaborator/Mentor: John Marshall, Brown University

Faculty Development Projects

Genome Stability through Bloom Syndrome Helicase and Rad51 Complex Formation (2005-2008)
Investigator: Karen Almeida, Rhode Island College
Mentor: Robert Sobol, University of Pittsburgh

Defining a Role for BCP1 in the DNA Damage Response of Saccharomyces cerevisiae (2009-2012)
Investigator: Deborah Britt, Rhode Island College
Mentor: Anatoly Zhitkovich, Brown University

Genetic and Molecular Analysis of Aging and Apoptosis in the Yeast, Saccharomyces (2005-2008)
Investigator: Nicanor Austriaco, Providence College
Mentor: Brian Kennedy, University of Washington School of Medicine

The Role for the Aryl Hydrocarbon Receptor in Netrin-1 Signaling (2005-2007)
Investigator: Joseph Bartoe, Providence College
Mentor: Julie Kauer, Brown University

Effects of Autonomy-Relatedness and Stress Response on Adolescent Risk Behavior (2012-2014)
Investigator: Emily Cook, Rhode Island College
Mentor: Laura Stroud, Brown University

The Tumorigenicity Potential of LRH1 in Pancreatic Caner (2012-2014)
Investigator: Xiaoqun Dong, University of Rhode Island
Mentor: Jack Wands, Brown University

E. Hystolica EhADH2 Enzyme as Anti-Amoebic Target (2004-2009)
Investigator: Avelina Espinosa, Roger Williams University
Mentor: Daniel Eichinger, New York University

Methyl Tertiary-Butyl Ether Causes Testicular Injury (2004-2008)
Investigator: Eric Hall, Rhode Island College
Mentor: Kim Boekelheide, Brown University

Growth Control in the Testis and Molecular Mechanisms of Testicular Homeostasis in Toxicant-Induced Testicular Injury (2004-2007)
Investigator: Mary Hixon, Brown University
Mentor: Kim Boekelheide, Brown University

Maintaining DNA Replication Fork Stability: Role of the Fanconi Anemia Pathway (2007-2010)
Investigator: Niall Howlett, University of Rhode Island
Mentor: Ralph Scully, Beth Israel Deaconess Hospital and Harvard University

Modulation of D2-like Dopamine Receptor-mediated Striatal Signaling Pathways by RGS9-2 (2007-2010)
Investigator: Abraham Kovoor, University of Rhode Island
Mentor: Ronald Duman, Yale University

Synthesis of New Polyamines for siRNA Complexation and Delivery (2010-2013)
Investigator: Mindy Levine, University of Rhode Island
Mentor: James Manley, Columbia University

Photothermal-chemotherapy of Melanoma with Targeted Cisplatin-loaded Hollow Gold Nanospheres (2010-2014)
Investigator: Wei Lu, University of Rhode Island
Mentor: Vincent Rotello, University of Massachusetts – Amherst

Mechanistic Studies of Protein Tyrosine Kinase Activation by Arsenite (2004-2005)
Investigator: Keykavous Parang, University of Rhode Island
Mentors: Bingfang Yan, University of Rhode Island, Bongsup Cho, University of Rhode Island, & Zahir Shaikh, University of Rhode Island

The Effect of Molecular Toxins on Protein Phosphates 1 Targeting (2007-2008)
Investigator: Wolfgang Peti, Brown University
Mentor: Edward Hawrot, Brown University

Mechanisms of Bacterial Mediation of Dinoflagellate Toxigenesis (2004-2004)
Investigator: David Rowley, University of Rhode Island
Mentor: Yuzuru Shimizu, University of Rhode Island

Molecular and Biochemical Characterization of a Secreted Lipase in Leishmania (2004-2009)
Investigator: Alison Shakarian, Salve Regina University
Mentor: David Nelson, University of Rhode Island

Reservatrol Induction of Gene Expression via Activation of CAR and Nrf2 (2006-2009)
Investigator: Angela Slitt, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Constitutive Androstane Receptor (CAR) Activation and Intracellular Transport (2007-2010)
Investigator: Matthew Stoner, University of Rhode Island
Mentor: Karen Lounsbury, University of Vermont

Characterization of Pyrethroids on Sperm Voltage-Sensitive Calcium Channels (2005-2008)
Investigator: Steven Symington, Salve Regina University
Mentor: Kim Boekelheide, Brown University

Mechanism of C-SRC Activation by Oxidative Stress (2004-2005)
Investigator: Gongqin Sun, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Mercury Contaminants in Commercial and Recreational Finfish of Narragansett Bay, Rhode Island (2006-2009)
Investigator: David Taylor, Roger Williams University
Mentor: Diane Nacci, Environmental Protection Agency

Role of the Antizyme Family During Xenopus Development (2004-2008)
Investigator: Charles Toth, Providence College
Mentor: Kim Boekelheide, Brown University

Cell Signaling Leading to UV-Induced Cell Injury (2004-2005)
Investigator: Yinsheng Wan, Providence College
Mentor: Bingfang Yan, University of Rhode Island

Heavy Metal-Induced Alteration of Cardiovascular Development (2004-2008)
Investigator: Kerri Warren, Roger Williams University
Mentors: Robert Rodgers, University of Rhode Island & Zahir Shaikh, University of Rhode Island

Proposal Development Projects

Maintaining DNA Replication Fork Stability: Role of the Fanconi Anemia Pathway (2009-2010)
Investigator: Niall Howlett, University of Rhode Island
Mentor: Ralph Scully, Beth Israel Deaconess Hospital and Harvard University

Role of Striatal-specific RGS Protein, RGS9-2, in Cellular Signaling Pathways (2009-2011)
Investigator: Abraham Kovoor, University of Rhode Island
Mentor: Ronald Stanton Duman, Yale University

Constitutive Androstane Recptor (CAR) Activation and Intracellular Transport (2009-2010)
Investigator: Matthew Stoner, University of Rhode Island
Mentor: Karen Lounsbury, University of Vermont

Undergraduate Student Training Projects

NAMPT Regulation Through Post Translational Modification (2012-2014)
Investigator: Karen Almeida, Rhode Island College
Mentor: Robert Sobol, University of Pittsburgh

A Novel Animal Model of Non-Suicidal Self-Injury (NSSI) (2012-2014)
Investigator: Christopher Bloom, Providence College
Mentor: Matthew Nock, Harvard University

Defining a Role for BCP1 in the DNA Damage Response of Saccharomyces cerevisiae (2012-2014)
Investigator: Deborah Britt, Rhode Island College
Mentor: Niall Howlett, University of Rhode Island

Characterization of Kinesin-3 and Kinesin-3 Cargo in Transit with the Axon (2009-2012)
Investigator: Joseph DeGiorgis, Providence College
Mentor: Thomas Reese, National Institutes of Health

Distribution and Regulation of the Amyloid Procursor of Alzheimer’s (AD) (2012-2014)
Investigator: Joseph DeGiorgis, Providence College
Mentor: Thomas Reese, National Institutes of Health

Anearobic Enzymes as Targets of Novel Anti-Infective Therapeutics (2012-2014)
Investigator: Avelina Espinosa, Roger Williams University
Mentor: Daniel Eichenger, New York University

Early Comprehension of Nouns and Verbs (2009-2012)
Investigator: Beverly Goldfield, Rhode Island College
Mentor: J. Steven Reznick, University of North Carolina

An Experimental Test of Intergroup Relations Model: Understanding the Origins of Intergroup Conflict (2009-2012)
Investigator: Thomas Malloy, Rhode Island College
Mentor: David Kenny, University of Connecticut

Population Genetics and Genome Evolution of Viruses in an Aquatic Environment (2009-2010)
Investigator: Marcia Marston, Roger Williams University
Mentor: David Rand, Brown University

Gene Divergence of Aryl Hydrocarbon Receptors (2009-2012)
Investigator: Rebeka Merson, Rhode Island College
Mentor: Mark Hahn, Woods Hole Oceanographic Institute

Internet-Based Addiction Counselor Education Study (2009-2012)
Investigator: Robin Montvilo, Rhode Island College
Mentor: Kat Quina, University of Rhode Island

Nano-Biomarker Arrays for Cancer Diagnostics (2012-2014)
Investigator: Bernard Munge, Salve Regina University
Mentor: James Rusling, University of Connecticut

Small Regulatory RNAs in the Metal Reducing Bacterium Shewanella oneidensis (2012-2014)
Investigator: Brett Pellock, Providence College
Mentor: Mary Allen, Wellesley College

Examination of UFD2A/UBE4B Function During Myogenesis In Vivo (2012-2014)
Investigator: Sarah Spinette, Rhode Island College
Mentor: David Goldhamer, University of Connecticut

The Physiological Role of Plant Phenolics in Plant and Mammalian Cell Growth (2012-2014)
Investigator: John-David Swanson, Salve Regina University
Mentor: Marie Chow, University of Arkansas

The Comparison of Three Behavioral Therapy Approaches for Children with Autism in Terms of Acquisition of Joint Attention (2009-2012)
Investigator: Sheila Quinn, Salve Regina University
Mentor: Stephen Sheinkopf, Brown University

Microinjection of Rat Brain Synaptoemma into Xenospus Oocytes (2012-2014)
Investigator: Steven Symmington, Salve Regina University
Mentor: J. Marshall Clark, University of Massachusetts – Amherst

The Cognitive Representation of Pretense (2012-2014)
Investigator: Jennifer Van Reet, Providence College
Mentor: David Marc Sobel, Brown University

Pilot Projects

A Quantitative Proteomics Approach to Understanding the Sigma-1 Receptor Signaling Pathways (2008-2009)
Investigator: Carthene Bazemore-Walker, Brown University
Mentor: Wayne Bowen, Brown University

Exploring Nucleocytoplasmic Shuttling of Metabolic Enzymes (2006-2007)
Investigator: Alexander Brodsky, Brown University
Mentor: Stephen L. Helfand, Brown University

Relating Biomembrane Disruption to the Potential Toxicity of Synthetic Inorganic Nanoparticles (2007-2008)
Investigator: Geoffrey Bothun, University of Rhode Island
Mentor: Arijit Bose, University of Rhode Island

Synthesis of Next-Generation Inhibitors of Botulinum Neurotoxin (2008-2009)
Investigator: Brenton DeBoef, University of Rhode Island
Mentor: William Euler, University of Rhode Island

Total Synthesis of UCS1025A and Derivatives Thereof for Use as Anti-Telomerase Agents (2005-2006)
Investigator: Brenton DeBoef, University of Rhode Island
Mentor: William Euler, University of Rhode Island

Genetic Properties of DNA Damage Induced by Peroxynitrite (2008-2009)
Investigator: Sarah Delaney, Brown University
Mentor: Anatoly Zhitkovich, Brown University

Mutagenesis and Toxicity of Peroxynitrite-Induced DNA Lesions in Human Cells (2007-2008)
Investigator: Sarah Delaney, Brown University
Mentor: Anatoly Zhitkovich, Brown University

Transcriptional Regulation of Bile Salt Export Pump (2006-2007)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Transcriptional Regulation of Bile Salt Export Pump by Endobiotics and Xenobiotics (2005-2006)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Toxicological Significance of Bile Export Pump (2004-2005)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Mechanisms for Estrogen-Mediated Transrepression of Human Bile Salt Export Pump (2008-2009)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Dissecting the Gene Regulatory Network for Epidermis (2008-2009)
Investigator: Steven Irvine, University of Rhode Island
Mentor: David Nelson, University of Rhode Island

Dissecting Regulation of Intracellular Vesicle Trafficking in a Tick Salivary Gland Model (2006-2007)
Investigator: Shahid Karim, University of Rhode Island
Mentors: Thomas N. Mather, University of Rhode Island & Gary Wessel, Brown University

Fragile Polymer Backbones for Disease Treatment Materials: Organocatalytic Ring-Opening Polymerization of Thioesters (2013-2014)
Investigator: Matthew Kiesewetter, University of Rhode Island
Mentors: Geoffrey Bothun, University of Rhode Island & Gary Wessel, Brown University

Estrogen Sulfotransferase and Estradiol Homeostasis in Mammary Epithelial Cells (2005-2006)
Investigator: Roberta King, University of Rhode Island
Mentors: Bongsup Cho, University of Rhode Island & Bingfang Yan, University of Rhode Island

Estrogen Sulfotransferase Inhibition and Breast Cancer (2004-2005)
Investigator: Roberta King, University of Rhode Island
Mentors: Bongsup Cho, University of Rhode Island & Bingfang Yan, University of Rhode Island

The Effects of Early Embryonic Exposure to PCBs on the Developing Nervous System (2007-2008)
Investigator: Jill Kreiling, Brown University
Mentor: Surendra Sharma, Brown University

Development of a New Class of Antibiotics (2005-2006)
Investigator: Thilo Lange, Brown University
Mentor: Susan Gerbi, Brown University

The Causes and Consequences of Genomic Change in Parasitic Oomycetes (2010-2011)
Investigator: Christopher Lane, University of Rhode Island
Mentor: David Nelson, University of Rhode Island

Evaluating Alpha Toxin and Biofilm Formation in Staphylococcus Aureus Through the Accessory Gene Regulator Operon (agr) (2006-2007)
Investigator: Kerry LaPlante, University of Rhode Island
Mentor: David Rowley, University of Rhode Island

Antimicrobial Agents that Inhibit Alpha-Toxin, Prevent Biofilm Formation in Staphylococcus aureus (2005-2006)
Investigator: Kerry LaPlante, University of Rhode Island
Mentor: David Rowley, University of Rhode Island

Establishing Sub-nuclear Domains of Coordinate Gene Regulation (2010-2011)
Investigator: Erica Larschan, Brown University
Mentor: Stephen Helfand, Brown University

Profile of miRNA Expression Alterations by Endocrine Disrupting Toxicants (2007-2008)
Investigator: Carmen Marsit, Brown University
Mentor: Kim Boekelheide, Brown University

Tumor-Penetrating Acetalated Dextran Nanoparticles Capable of Tandem Delivery of Radiosensitizing Agents for the Treatment of Lung Cancer (2013-2014)
Investigator: Samantha Meenach, University of Rhode Island
Mentor: Arijit Bose, University of Rhode Island

Surface Hsc/OC.10 Confers a Growth and Survival Advantage to Oval Cells, Cholangiocytes and Hepatocellular Carcinomas (2007-2008)
Investigator: David Mills, Rhode Island Hospital
Mentor: Douglas Hixson, Brown University

A Field-Deployable Direct Readout Solution-Based SERS method for the Rapid and Sensitive Detection of Pesticides in Fruits and Vegetables (2008-2009)
Investigator: Radha Narayanan, University of Rhode Island
Mentor: Chris Brown, University of Rhode Island

The Dynamic Cellular Localization of TrpM1 (2008-2009)
Investigator: Elena Oancea, Brown University
Mentor: Julie Kauer, Brown University

The Effects of Environmental Oxidants on HePTP Structure and MAP Kinase Interaction (2007-2008)
Investigator: Rebecca Page, Brown University
Mentor: Kristi Wharton, Brown University

Synthesis of Next-Generation Inhibitors of Botulinum Neurotoxin (2008-2009)
Investigator: Becky Sartini, University of Rhode Island
Mentor: Gary Wessel, Brown University

Anti-Inflamatory Effects of Strawberry Polyphenols via Sub-Cellular Signaling Pathways in COX-2 Expressing Human Colon Cancer Cell Line (HT-29) (2008-2009)
Investigator: Navindra Seeram, University of Rhode Island
Mentor: Clinton Chichester, University of Rhode Island

Design of Anticancer Cytotoxins (2004-2005)
Investigator: Yana K. Reshetnyak, University of Rhode Island
Mentor: Clinton Chichester, University of Rhode Island

Pilot Undergraduate Student Training Projects

The Interactome of NAMPT: The Influence of Energetics on DNA Repair (2011-2012)
Investigator: Karen Almeida, Rhode Island College

The Effects of Volatile Organic Compounds on Immune Cell Function (2010-2011)
Investigator: Kirsten Hokeness, Bryant University

Genetic Characterization of Bax Inhibitor (BXI1) Function in the Budding Yeast, Saccharomyces (2012-2014)
Investigator: Nicanor Austriaco, Providence College

Genetic Characterization of UTH1 and BXI1, Two Genes Involved in Yeast Pogrammed Cell Death (2011-2012)
Investigator: Nicanor Austriaco, Providence College

Perceptions of Multiply Stigmatized Individuals (2009-2010)
Investigator: Kelly Brooks, Roger Williams University

The Effectiveness of Undergraduates as Trained Listeners for the Bereaved: A Pilot Study of Impact on Symptoms and Cognitions (2009-2010)
Investigators: Bonita Cade & Kim Knight, Roger Williams University

Assessing Comprehension Across Word Class (2013-2014)
Investigator: Beverly Goldfield, Rhode Island College

Assessing Comprehension in Young Children (2012-2013)
Investigator: Beverly Goldfield, Rhode Island College

The Study of Calcium Dynamics with a Comprehensive Model (2010-2011)
Investigator: Sandor Kadar, Salve Regina University

Development of a Comprehensive Model for Calcium Signaling (2009-2010)
Investigator: Sandor Kadar, Salve Regina University

The Effects of Afrocentric Features and Crime Stereotypes on Visual Attention to Faces (2013-2014)
Investigator: Thomas Malloy, Rhode Island College

The Effects of Perceiver Motivation and Visual Attention Training on Reduction of Cross Race Facial Recognition Bias (2012-2013)
Investigator: Thomas Malloy, Rhode Island College

Computational Analysis and Modeling of Human Eye Movements (2013-2014)
Investigator: Colleen Marlow, Rhode Island College

Horizontal Gene Exchnge and Genome Evolution of Viruses in an Aquatic Environment (2008-2009)
Investigator: Marcia Marston, Roger Williams University

Horizontal Gene Exchange and Genome Evolution of Myoviruses in an Aquatic Environment (2007-2008)
Investigator: Marcia Marston, Roger Williams University

Testing the Myogenic Code Hypothesis (2013-2014)
Investigator: Thomas Meedel, Rhode Island College

Experimental Test of the Myogenic Code Hypothesis (2012-2013)
Investigator: Thomas Meedel, Rhode Island College

Design and Synthesis of Potential Qurom-Sensing Inhibitors (2013-2014)
Investigator: Susan Meschwitz, Salve Regina University

The Design, Synthesis, and Biological Evaluation of Potentially Novel Anti-infective Agents (2012-2013)
Investigator: Susan Meschwitz, Salve Regina University

Chemical and Biological Studies of the Antibacterial Agent Eudistomin U (2013-2014)
Investigator: Seann Mulcahy, Providence College

The Effect of Oxidative Stress on the Transport, Sequestration, Storage and Use of Sufate and Molybdenum in Chlamydomonas reinhardtii (2009-2010)
Investigator: Erica Oduaran, Roger Williams University

Promoting Apoptosis Using Small Molecule Inhibitors of Bcl-xL (2006-2007)
Investigator: Jay Pike, Providence College

Interactions of Fungal Pathogens and Immune Cells: Mechanisms for Pathogenic Success (2011-2012)
Investigator: Christopher Reid & Kirsten Hokeness, Bryant University

Characterization of Differentially Expressed Genes Among Pathogenic Species of Leishmania (2013-2014)
Investigator: Alison Shakarian, Salve Regina University

Identification of Differentially Expressed Genes Among Leishmania Species (2012-2013)
Investigator: Alison Shakarian, Salve Regina University

Identification of Differentially Expressed Genes Among Leishmania Species (2011-2012)
Investigator: Alison Shakarian, Salve Regina University

Identification and Characterization of Differentially Expressed Genes Among Leishmania Species to Discover Novel Targets for the Development of Non-toxic Compounds for the Treatment of Leishmaniasis (2010-2011)
Investigator: Alison Shakarian, Salve Regina University

Development of Molecular Tools for the Analysis of Heavy Metal Tolerance in Lancelets (2011-2012)
Investigator: Thomas Sorger, Roger Williams University

Mercury and Selenium Concentrations in Rhode Island Estuarine and Coastal Fisheries (2013-2014)
Investigator: David Taylor, Roger Williams University

Mercury Contamination in Rhode Island Estuarine and Coastal Fisheries (2012-2013)
Investigator: David Taylor, Roger Williams University

Modeling and Characterizing IDH Mutant Gliomas in Drosophil melanogaster (2013-2014)
Investigator: Marla Tipping, Providence College

The Development of the Representation of Pretense (2011-2012)
Investigator: Jennifer Van Reet, Providence College

Investigation of the Role of mTORC1 in Human Melanoma (2013-2014)
Investigator: Yinsheng Wan, Providence College

The Molecular Mechanisms of the Resistance to Oxidative Stress in Melanoma Cells (2012-2013)
Investigator: Yinsheng Wan, Providence College

Mechanisms of CpG-ODN’s against UV-induced Cell Death (2011-2012)
Investigator: Yinsheng Wan, Providence College

Arylphosphonium Salt Conjugates: Diagnostic, Cell-Imaging Anticancer Agents; Synthesis and Screening (2013-2014)
Investigator: John C. Williams, Jr., Rhode Island College

Arylphosphonium Salt Conjugates: Diagnostic, Cell-Imaging Anticancer Agents; Synthesis and Screening (2012-2013)
Investigator: John Williams, Jr., Rhode Island College

Anticancer Agents and Antibiotic Polymers (2011-2012)
Investigator: John Williams, Jr., Rhode Island College

Microwave Synthesis of Arylphosphonium Salts Bound to Flourescent Markers, Antibiotic Polymers, and DNA and Protein Binders (2010-2011)
Investigator: John Williams, Jr., Rhode Island College

Microwave Synthesis of Arylphosphonium Salts Bound to Flourescent Markers, Antibiotic Polymers, and DNA and Protein Binders (2009-2010)
Investigator: John Williams, Jr., Rhode Island College

Synthesis, Screening, Toxicology and Computational Chemistry of Biologically-Active Arylphosphonuium Salts (2008-2009)
Investigator: John C. Williams, Jr., Rhode Island College

Synthesis, Analysis, Toxicity Screening and Computational Chemistry of Arylphosphonium Salts Conjugated with Lipids and Polypeptides (2006-2008)
Investigator: John C. Williams, Jr., Rhode Island College

RI-BRIN (2001-2004)

Faculty Development Projects

Pharmacokinetics and Pharmacodynamics of Immunosuppressive Agents (2002-2004)
Investigator: Fatemeh Aklaghi, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Neural Architecture and the Mechanisms for Learning and Memory Storage (2001-2004)
Investigator: Brian Blais, Bryant College
Mentor: Nasser H. Zawia, University of Rhode Island

Developing a Tailored, Mismatched Intervention for Increasing the Physical Activity Behavior of Sedentary Adults (2001-2004)
Investigator: Bryan Blissmer, University of Rhode Island
Mentor: Wayne F. Velicer, University of Rhode Island

The Effects of Endocrine Disruptors on Complex Behavior Patterns (2001-2003)
Investigator: Ethan Clotfelter, Providence College
Mentor: Zahir Shaikh, University of Rhode Island

Localization of SP Family of Transcription Factors in the Developing Brain (2001-2004)
Investigator: Suzanne Conklin, Rhode Island College
Mentor: Nasser H. Zawia, University of Rhode Island

Acrylamide and Intermediate Filaments in Mouse Sertoli Cells (2001-2004)
Investigator: Eric Hall, Rhode Island College
Mentor: Kim Boekelheide, Brown University

A Mechanism for Phthalate-Induced Testicular Injury: Cadherin Disruption (2001-2003)
Investigator: Kamin Johnson, Brown University
Mentor: Kim Boekelheide, Brown University

Co-Variation in Alcohol Abuse and Smoking in Adolescents and Their Parents (2001-2004)
Investigator: Randi Kim, Rhode Island College
Mentor: James Prochaska, University of Rhode Island

Sulfotransferase Inhibitors: Chemoprevention and Drug Interactions (2001-2004)
Investigator: Roberta King, University of Rhode Island
Mentor: Bongsup Cho, University of Rhode Island

Mental Health Benefits from Cancer Prevention (2001-2004)
Investigator: Daniel Koonce, University of Rhode Island
Mentor: Wayne F. Velicer, University of Rhode Island

A 3-D Model of the Transport and Diffusion of Chemotherapy Drugs into the Brain for Tumor Volume Reduction (2002-2004)
Investigator: Donna M. Meyer, University of Rhode Island
Mentor: Ying Sun, University of Rhode Island

Changes in High Risk Sex and Cigarette Smoking as Preludes to Immunization for Hepatitis (2001-2004)
Investigator: Mary O’Keeffe, Providence College
Mentor: James Prochaska, University of Rhode Island

Metal Contamination and Human Health (2001-2004)
Investigator: Steven O’Shea, Roger Williams University
Mentor: Zahir Shaikh, University of Rhode Island

Mechanisms of Diolepoxide-DNA Interaction (2001-2004)
Investigator: Kenneth R. Overly, Providence College
Mentor: Bongsup Cho, University of Rhode Island

Biososteres of Tyrosine Phosphate as Inhibitors of the SH2 Domain of Tyrosine Kinases (2001-2004)
Investigator: Keykavous Parang, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Drugs from the Sea: Especially from Marine Microbes (2001-2004)
Investigator: David Rowley, University of Rhode Island
Mentor: Yuzuru Shimizu, University of Rhode Island

The Role of the 26S Proteasome Component Rpn6 in Directing Ubiquitinated Substrates to the Proteasome (2002-2004)
Investigator: Jeffrey D. Singer, Brown University
Mentor: John Sedivy, Brown University

Metal Cations in PTK Catalysts and Inhibitor Design (2001-2004)
Investigator: Gongqin Sun, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Targeting of Proteins to the 26S Proteasome: Determination of Antizyme Function (2001-2004)
Investigator: Charles Toth, Providence College
Mentor: Bingfang Yan, University of Rhode Island

Regional Electrophysiological Effects of Heterogeneous Cardiac Deformation (2002-2004)
Investigator: Frederick J. Vetter, University of Rhode Island
Mentors: Ying Sun, University of Rhode Island & Robert L. Rodgers, University of Rhode Island

Herb-Mediated Blockade on UV Signaling (2001-2004)
Investigator: Yinsheng Wan, Providence College
Mentor: Bingfang Yan, University of Rhode Island

Mathematical Modeling of Cardiovascular Mechanics and Metabolism (2001-2004)
Investigator: Li Wu, University of Rhode Island
Mentors: Ying Sun, University of Rhode Island & Robert L. Rodgers, University of Rhode Island

Pilot Projects

Distribution and Metabolism of Immunosuppressive Agents (2001-2002)
Investigator: Fatemeh Akhlaghi, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Genetic Characterization of the Different Histological Types of Malignancy in Colorectal Cancer (2003-2004)
Investigator: Elisaabeth Arévalo, Providence College
Mentor: Bongsup Cho, University of Rhode Island

Fluorinated Membranes – A Model for Raft Formation (2001-2002)
Investigator: Amit Basu, Brown University
Mentor: Matthew Zimmit, Brown University

Electrocardiographic and Hemodynamic Effects of a Dietary Weight Loss Supplement Containing Ephedrine and Caffeine (2002-2003)
Investigator: Michael Caron, University of Rhode Island
Mentor: Robert Rodgers, University of Rhode Island

Phase Space Warping Based Diagnosis of Long-Term Changes in Human Coordination (2002-2003)
Investigator: David Chelidze, University of Rhode Island
Mentor: Arun Shukla, University of Rhode Island

Metal Interactions in Csk Protein-Tyrosine Kinase (2003-2004)
Investigator: Glenisson de Olivéira, Rhode Island College
Mentor: Bingfang Yan, University of Rhode Island

Novel Antimicrobial Peptides of Marine Origin: Recombinant Expression and Processing by Proteolytic Enzymes (2003-2004)
Investigator: Marta Gómez-Chiarri, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island

Transgenic Cis-Regulatory Analysis of a Simple Two-Gene Cluster (2002-2003)
Investigator: Steve Irvine, University of Rhode Island
Mentor: Nasser Zawia, University of Rhode Island

Transgenic Cis-Regulatory Analysis of Development Genes in Ascidians (2003-2004)
Investigator: Steve Irvine, University of Rhode Island
Mentor: Nasser Zawia, University of Rhode Island

Stochastic Resonance in a Subexcitable System (2001-2002)
Investigator: Sandor Kadar, Salve Regina University
Mentor: Bongsup Cho, University of Rhode Island

Spatiotemporal Stochastic Resonance in a Subexcitable Chemical System (2003-2004)
Investigator: Sandor Kadar, Salve Regina University
Mentor: Bongsup Cho, University of Rhode Island

Design of Sensors for the Detection of Organohalides and Organophophates Using Time-Resolved Fluorescence (2002-2003)
Investigator: Jaycoda Major, University of Rhode Island
Mentor: William Euler, University of Rhode Island

Separation of Wear Debris in Total Joint Replacements Using Bio-Ferrography (2001-2002)
Investigator: Donna Meyer, University of Rhode Island
Mentor: Ying Sun, University of Rhode Island

Latent Growth Curve Modeling of Health Behavior Changes Among Adolescents (2002-2003)
Investigator: Nansook Park, University of Rhode Island
Mentor: Wayne Velicer, University of Rhode Island

Mechanisms of Emotional Modulation in Human Visual Cortex (2003-2004)
Investigator: Luiz Pessoa, Brown University
Mentor: Sheila Blumstein, Brown University

Evaluation of Graded Materials for Use in Total Joint Replacement (2002-2003)
Investigator: Carl-Ernst Rousseau, University of Rhode Island
Mentor: Arun Shukla, University of Rhode Island

Evaluation of Contact Stresses in Graded Materials Used in Total Joint Replacement (2003-2004)
Investigator: Carl-Ernst Rousseau, University of Rhode Island
Mentor: Arun Shukla, University of Rhode Island

Manufacturing Processes for Biomedical Implants Using Laser Engineered Net Shaping (LENS) Technology (2003-2004)
Investigator: Valerie Maier Speredelozzi, University of Rhode Island
Mentor: Arun Shukla, University of Rhode Island

Brain Structure and Activation in Children Born Preterm (2002-2004)
Investigator: Mary Sullivan, University of Rhode Island
Mentor: Margaret McGrath, University of Rhode Island

A Quantitative Description of the Cardiac Papillary Muscle Insertion (2001-2002)
Investigator: Fred Vetter, University of Rhode Island
Mentors: Robert Rodgers, University of Rhode Island & Ying Sun, University of Rhode Island

Evaluation of Deer Tick Eggs Antigens as an Anti-Tick Vaccine (2001-2002)
Investigator: Ulysses Whitworth, University of Rhode Island
Mentor: Nasser Zawia, University of Rhode Island

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