- Associate Professor
- Cell and Molecular Biology
- Phone: 401.874.5049
- Email: Martin@uri.edu
Our research group participates in many research alliances across disciplinary boundaries and Dr Martin strongly believes this is the best way to sustain creativity and productivity and to invigorate the research enterprise at URI and in the state of RI.
The new CELS-URI Interdisciplinary Graduate Program in Neurosciences (INP), which I participate in as a faculty member from CMB, offers us a wonderful opportunity to build on our current research efforts in peptide design and combinatorial peptide synthesis, enabling us to explore the exciting possibility that peptides play key roles in regulating neuronal signaling, and also to better understand how lipids interact with specific amino acid sequence patterns, so we can devise ways to assess and improve the ability of peptides to fuse with membranes and cross the blood-brain barrier.
Our current work has focused on structure-based design of new antimicrobial peptides, and since AMP production in endothelial tissue has recently been shown to be modulated by the effects of psychological stress, we can effectively investigate this type of non-traditional psycho-biological mechanism by working together with appropriate collaborators from the neuroscience community at URI through INP.
This recent and surprising preliminary research result pointing to an overlap between psychology and antimicrobial peptide production is just one example of the value of studying peptides and probing their structural and chemical roles in human health, by looking at effects on brain chemistry, cognition, and behavior.
Personal website: http://web.uri.edu/cmb/lenore-m-martin/