P20 COBRE GM104317 (PI- Rothman, Alan L.) 9/1/13-5/31/2018
Immune-Based Interventions Against Infectious Diseases
The major goals of this project are to develop a multidisciplinary and trans-institutional research program in infectious diseases immunology in Providence, Rhode Island.
Role: Project Leader
Project title: Autophagy Regulation of Innate and Adaptive Immunity in Dengue
P01 AI34533 (PI- Rothman, Alan L.) 7/18/13–7/17/18
Flavivirus Infections: Pathogenesis and Prevention
The major goals of this project are: 1) to define the pathophysiologic alterations in dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) with particular attention to activation of virus-specific T lymphocytes, and 2) to define host immunologic responses and genetic factors that are associated with an increased risk for DHF during secondary dengue virus infection.
Role: Co-Investigator, Project 2
U19 AI57319 (PI- Finberg, Robert) 9/30/03-3/31/14
Cellular Immunity to Category A-C Viruses in Humans
The major goals of this project are: 1) to characterize T cell responses to poxviruses, hantaviruses, and flaviviruses and their roles in vaccine-induced protection and pathogenesis of disease, 2) to develop new technologies to analyze virus-specific T lymphocytes in clinical specimens, and 3) to support pilot projects and education of new investigators in biodefense-related research.
Role: Co-Investigator, Technology Development Project
U19AI082642 (PI- A.S. DeGroot) 7/01/11-6/30/12
Translational Immunology Research and Accelerated [vaccine] Development (TRIAD)- PARENT
Pilot Project: Defining Immunodominant Epitopes in Heterologous Secondary DENV Infections
The goal of this project is to define the correlation between T cell cytokine responses to dengue viral epitopes and their predicted HLA- and TCR-binding attributes.
Role: Pilot Project Leader
N.I.H. Immunology Training Grant, UMass Medical School, 2005.
N.I.H. Immunology Training Grant, UMass Medical School, 2000.