College of Pharmacy

Avedisian Hall, 7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.eduOffice: 401.874.2761 Fax: 401.874.2181

URI
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Navindra Seeram, Ph.D.

  • Associate Professor
  • Office: 495B Lab: 440
  • Phone: 401.874.9367
  • Email: nseeram@uri.edu
  • Mailing Address: 7 Greenhouse Road, Kingston, RI 02881

Biography

researchwebsiteNavindra P. Seeram, Ph.D., is an Associate Professor in the Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, USA. Prior to this, he was the Assistant Director of the UCLA Center for Human Nutrition in the Department of Medicine, University of California, Los Angeles, and an Assistant Professor in the UCLA School of Medicine. His research group, the Bioactive Botanical Research Laboratory, investigates plant foods and natural products for therapeutic and preventive effects against chronic human diseases.

Dr. Seeram has co-authored over 145 original peer-reviewed research articles, 8 review articles, 17 book chapters, and 6 international patents. He has co-edited 3 books and is the founding editor of the Clinical Pharmacognosy book series published by CRC Press/Taylor and Francis. He serves on the advisory board of the American Botanical Council and on the editorial advisory boards of the Journal of Agricultural and Food Chemistry, the Journal of Berry Research, and the International Journal of Applied Research in Natural Products.  He was the recipient of the 2009 Young Scientist Award from the Division of Agricultural and Food Chemistry of the American Chemical Society and was elected as the 2017 Chair of that Division. He is among the most highly cited scientists in Agricultural Sciences by Thomson Reuters (in 2014-2016 based on Web of Science indexed citations from 2002-2016) and is regularly quoted in the media and popular press about medicinal plant foods.  Dr. Seeram did his doctoral and postdoctoral studies at the University of the West Indies (in Jamaica) and at Michigan State University (MI, USA), respectively.

Professional Experience

July 2013-present:          Associate Professor with tenure, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Dec 2007-June 2013:     Assistant Professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Aug 2003-Dec 2007:      Assistant Adjunct Professor, Division of Clinical Nutrition, Department of Medicine, University of California, Los Angeles, CA, USA.

Nov 2002- Dec 2007:     Assistant Director, UCLA Center for Human Nutrition, Department of Medicine, University of California, Los Angeles, CA, USA.

July 1999-Sep 1999:       Senior Scientific Officer, Scientific Research Council, Kingston, Jamaica, West Indies.

June 1998-June 1999:     Senior Forensic Officer, Police Forensic Laboratory, Ministry of National Security, Kingston, Jamaica, West Indies.

June 1992-June 1998:     Tutorial/Teaching Assistant, University of the West Indies, Kingston, Jamaica, West Indies.

June 1990-June 1992:     Chemistry Teacher, Manchester High School, Mandeville, Jamaica, West Indies.

Research

Bioassay-guided discovery of natural products from medicinal plants including medicinal foods targeting neurodegenerative diseases, cancer, diabetes, and inflammation; Investigation of bioavailability, metabolism, tissue disposition, and mechanisms of action of bioactive food components.

Education

Post-Doctoral Fellow, Michigan State University, 1999-2002

Ph.D. Natural Products Chemistry, University of the West Indies, Kingston, Jamaica, 1998

B.Sc., Chemistry (major) & Biology (minor) with Distinction, University of Guyana, Georgetown, Guyana, South America, 1990.

Publications

  1. Li, Y.; Xu, J.; Yuan, C.; Ma, H.; Liu, T.T.; Liu, F.; Seeram, N.P.; Mu, Y.; Huang, X.; Li, L. Chemical composition and anti-hyperglycemic effects of triterpenoid enriched Eugenia jambolana berry extract. Journal of Functional Foods, 2017, 28, 1-10.
  2. Bin Muhsinah A.; Ma, H.; DaSilva, N.; Yuan, T.; Seeram, N.P. Bioactive glucitol-core containing gallotannins and other phytochemicals from silver maple (Acer saccharinum) leaves. Natural Products Communications, 2016, accepted.
  3. Liu, S.; Huang, D.; Morris-Natschke, S.; Ma, H.; Liu, Z.; Seeram, N.P.; Xu, J.; Lee, K-H; Gu, Q. Euphomilones A and B, ent-rosane diterpenoids with 7/5/6 and 5/7/6 skeletons from Euphorbia milii. Organic Letters, 2016, accepted.
  4. Luo, X.; Li, C.; Luo, P.; Lin, X.; Ma, H.; Seeram, N.P; Song, C.; Xu, J.; Gu. Q. Pterosin sesquiterpenoids from Pteris cretica as hypolipidemic agents via activating liver X receptors. Journal of Natural Products, 2016, accepted.
  5. Sun, J.; Ma, H.; Seeram, N.P.; Rowley, D.C. Detection of inulin, a prebiotic polysaccharide, in maple syrup. Journal of Agricultural and Food Chemistry, 2016, 64, 7142-7147.
  6. Liu, W.; Ma, H.; DaSilva, N.; Rose, K.; Johnson, S.L.; Zhang, L.; Wan, C.; Dain, J.; Seeram, N.P. Development of a neuroprotective potential algorithm for medicinal plants. Neurochemistry International, 2016, 100, 164-177.
  7. Mellado-Mojica, E.; Seeram, N.P.; Lopez, M.G. Comparative analysis of maple syrups and natural sweeteners: Carbohydrates composition and classification (differentiation) by HPAEC-PAD and FTIR spectroscopy-chemometrics, Journal of Food Composition and Analysis, 2016, 52, 1-8.
  8. Ma, H.; DaSilva, N.; Liu, W.; Nahar, P.P., Wei, Z.; Liu, Y.; Pham, P.T.; Crews, R.; Vattem, D.A.; Slitt, A.L.; Shaikh, Z.; Seeram, N.P. Effects of a standardized phenolic-enriched maple syrup extract on b-amyloid aggregation, neuroinflammation in microglial and neuronal cells, and b-amyloid induced neurotoxicity in Caenorhabditis elegans, Neurochemical Research, 2016, 41, 2836-2847.
  9. Beckford, F.A.; Brock, A.; Gonzalez-Sarrias, A.; Seeram, N.P. Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules, Journal of Molecular Structure, 2016, 1121, 156-166.
  10. Liu, Y.; Ma, H.; Seeram, N.P. Development and UFLC-MS/MS characterization of a product specific standard for phenolic quantification of maple food products. Journal of Agricultural and Food Chemistry, 2016, 64, 3311-3317.
  11. Beckford, F.A.; Stott, A.; Mbarushimana, P.C.; LeBlanc, M.A.; Hall, K.; Smith, S.; Bullock, J.L.; Houghton, D.J.; Holder, A.A.; Gerasimchuk, N.N.; Gonzalez-Sarrias, A.; Seeram, N.P. Anticancer, biophysical, and computational investigations of
    half-sandwich ruthenium(II) complexes: The effect of arene versus thiacrown face-cap. Interdisciplinary Journal of Chemistry, 2016, 1, 1-15.
  12. Ma, H.; Liu, W.; Frost, L.; Kirshenbaum, L.; Dain, J.; Seeram, N.P. Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential, Food and Function, 2016, 7, 2213-2222.
  13. Kresty, L.; Fromkes, J.; Frankel, W.; Hammond, C.D.; Seeram, N.P.; Baird, M.; Stoner, G.D. A phase I pilot study evaluating the beneficial effects of black raspberries in patients with Barrett’s esophagus. Oncotarget, 2016, DOI: 10.18632/oncotarget.10457.
  14. Sun, J.D.; Ma, H.; Liu, W.; Marais, J.; Khoo, C.; Dain, J.; Rowley, D.C.; Seeram, N.P. Effect of cranberry (Vaccinum macrocarpon) oligosaccharides on the formation of advanced glycation endproducts, Journal of Berry Research, 2016, 6, 149-158.
  15. Skrip, M.M.; Seeram, N.P.; Yuan, T.; Ma, H.; McWilliams, S.R. Dietary antioxidants and flight exercise affect how female birds allocate nutrients to eggs: how carry-over effects work, Journal of Experimental Biology, 2016, 219, 2716-2725.
  16. Chen, J.; Sun, J.D.; Deering, R.D.; DaSilva, N.; Seeram, N.P.; Wang, H.; Rowley, D.C.; Rhizoleucinoside, a rhamnolipid-amino alcohol hybrid from the rhizobial symbiont Bradyrhizobium BTAi1. Organic Letters, 2016, 18, 1490-1493.
  17. Gray, J.; Burgos, D.Z.; Yuan, T.; Seeram, N.; Rebar, R.; Follmer, R.; Heart, E. Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA. AJP-Endocrinology and Metabolism, 2016, 310, E394-E404.
  18. Sandhaus, S.; Taylor, T.; Edwards, T.; Huddlestown, A.; Wooten, Y.; Venkatraman, R.; Weber, R.T.; Gonzalez-Sarrias, A.; Martin, P.M.; Cagle, P.; Tse-Dinh, Y-C.; Beebe, S.J.; Seeram, N.; Holder, A.A. A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIa. Inorganic Chemistry Communications, 2016, 64, 45-49.
  19. Deering, R.W.; Chen, J.; Sun, J.; Ma, H.; Dubert, J.; Barja, J.L.; Seeram, N.P.; Wang, H.; Rowley, D.C. N-acyl dehydrotyrosines, tyrosine inhibitors from the marine bacterium, Thalassotalea PP2-459. Journal of Natural Products, 2016, 79, 447-450.
  20. Yuan, T.; Ma, H.; Liu, W.; Niesen, D.B.; Shah, N.; Crews, R.; Rose, K.N.; Vattem, D.A.; Seeram, N.P. Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chemical Neurosciences, 2016, 7, 26-33.
  21. Ma, H.; Wang, L.; Niesen, D.B.; Cai, A.; Cho, B.P.; Tan, W.; Gu, Q.; Xu, J.; Seeram, N.P. Structure activity related, mechanistic and modeling studies of gallotannins containing a glucitol core and a-glucosidase. RSC Advances, 2015, 5, 107904-107915.
  22. Zhang, Y.; Ma, H.; Liu, W.; Yuan, T.; Seeram, N.P. New antiglycative compounds from cumin (Cuminum cyminum) spice. Journal of Agricultural and Food Chemistry, 2015, 63, 10097-10102.
  23. Kapoor, R.; Ronnenberg, A.; Puleo, E.; Chatterton Jr., R.T.; Dorgan, J.F.; Seeram, N.P.; Sturgeon, S.R. Effects of pomegranate juice on hormonal biomarkers of breast cancer risk. Nutrition and Cancer, 2015, DOI:10.1080/01635581.2015.1073756.
  24. Zhang, L.; Tu, Z-C.; Yuan, T.; Ma, H.; Niesen, D.B.; Wang, H.; Seeram, N.P. New gallotannin and other phytochemicals from sycamore maple (Acer pseudoplatanus) leaves. Natural Products Communications, 2015, 10, 1977-1980.
  25. Zhang, Y.; Ma, H.; Yuan, T.; Seeram, N.P. Red maple (Acer rubrum) aerial parts as a source of bioactive phenolics. Natural Products Communications, 2015, 10, 1409-1412.
  26. Sun, J.; Marais, J.; Khoo, C.; LaPlante, K.; Givskov, M.; Tolker-Nielsen, T.; Vejborg, R.M.; Seeram, N.P.; Rowley, D.C. Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Eschericha coli. Journal of Functional Foods, 2015, 17, 235-242.
  27. Orr, K.K.; Feret, B.M.; Lemay, V.A.; Cohen, L.B.; MacDonnell, C.P.; Seeram, N.; Hume, A.L. Assessment of a hybrid team based learning (TBL) in a required self-care course. Currents in Pharmacy Teaching and Learning, 2015, http://dx.doi.org/10.1016/j.cptl.2015.04.016.
  28. Nahar, P.; Slitt, A.; Seeram, N.P. Anti-inflammatory effects of novel standardized solid lipid curcumin formulations. Journal of Medicinal Food, 2015, 18, 786-792.
  29. Ma, H.; Liu, W.; Frost, L.; Wang, L.; Kong, L.; Dain, J.A.; Seeram, N.P. The hydrolyzable gallotannin, penta-O-galloyl-b-D-glucopyranoside inhibits the formation of advanced glycation endproducts by protecting protein structure. Molecular BioSystems, 2015, 11, 1338-1347.
  30. Niesen, D.B.; Ma, H.; Yuan, T.; Bach II, A.C.; Henry, G.E.; Seeram, N.P. Phenolic constituents of Carex vulpinoidea seeds and their tyrosinase inhibitory activities. Natural Products Communications, 2015, 3, 491-493.
  31. Yuan, T.; Nahar, P.; Sharma, M.; Liu, K.; Slitt, A.; Aisa, H.A.; Seeram, N.P. Indazole-type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro. Journal of Natural Products, 2014, 77, 2316-2320.
  32. Ahmed, A.H.; Subaiea, G.M.; Eid, A.; Li, L.; Seeram, N.P.; Zawia, N.H. Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer’s disease animal model. Current Alzheimer Research, 2014, 11, 834-843.
  33. Liu, W.; Ma, H.; Frost, L.; Yuan, T.; Dain, J.A.; Seeram, N.P. Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species. Food and Function, 2014, 5, 2996-3004.
  34. Zhang, Y.; Yuan, T.; Li, L.; Nahar, P.; Slitt, A.; Seeram, N.P. Chemical compositional, biological, and safety studies of a novel maple syrup derived extract for nutraceutical applications. Journal of Agricultural and Food Chemistry, 2014, 62, 6687-6698.
  35. Kumar, K.; Schniper, S.; González-Sarrías, A.; Holder, A.A.; Sanders, N.; Sullivan, D.; Jarrett, W.L.; Davis, K.; Bai, F.; Seeram, N.P.; Kumar, V. Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation. European Journal of Medicinal Chemistry, 2014, 86, 81-86.
  36. Nahar, P.; Driscoll, M.; Li, L.; Slitt, A.L.; Seeram, N.P. Phenolic mediated anti-inflammatory effects of a maple syrup extract against RAW264.7 macrophages. Journal of Functional Foods, 2014, 6, 126-136.
  37. Guo, L.; Panderi, ; Yan, D.D.; Szulak, K.; Li, Y.; Chen, Y.T.; Ma, H.; Niesen, D.B.; Seeram, N.; Ahmed, A.; Yan, B.; Pantazatos, D.;  Lu, W. A comparative study of hollow copper sulfide nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano. 2013, 7, 8780-8793.
  38. Yuan, T.; Wan, C.; Ma, H.; Seeram, N.P. Novel phenolics from the flowers of Punica granatum and their α-glucosidase inhibitory activities, Planta Medica, 2013, 79, 1-6.
  39. Pericherla, K.; Shirazi, A.N.; Rao, V.K.; Tiwari, R.; DaSilva, N.; Mccaffrey, K.T.; Beni, Y.A.; González-Sarrías, A.; Seeram, N.P.; Parang, K.; Kumar, A. Synthesis and antiproliferative activities of quebecol and its analogs. Bioorganic Medicinal Chemistry Letters, 2013, 23, 5329-5331.
  40. Yuan, T.; Li, L.; Zhang, Y.; Seeram, N.P. Pasteurized and sterilized maple sap as functional beverages: Chemical composition and antioxidant activities. Journal of Functional Foods, 2013, 5, 1582-1590.
  41. Jean-Gilles, D.; Li, L.; Vaidyanathan, V.G.; King, R.; Cho, B.; Worthen, D.R.; Chichester, C.O.; Seeram, N.P. Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo. Chemico-Biological Interactions, 2013, 205, 90-99.
  42. Beckford, F.; Brock, A.; González-Sarrías, A.; Seeram, N.P. Novel microwave synthesis of half-sandwich [(h6-C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity. Applied Organometallic Chemistry, 2013, 27, 425-434.
  43. Bolser, J.A.; Alan, R.R.; Smith, A.D.; Li, L.; Seeram, N.P.; McWilliams, S.R. Birds select fruits with more anthocyanins and phenolic compounds during autumn migration, Wilson Journal of Ornithology, 2013, 125, 97-108.
  44. González-Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S- and G2/M-cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels. Food Chemistry, 2013, 136, 636-642.
  45. Woode, D.R.; Aiyer, H.S.; Sie, N.; Zwart, A.L.; Li, L.; Seeram, N.P.; Clarke, R. Effect of berry extracts on fulvestrant (ICI 182,780) sensitive and resistant cell lines, International Journal of Breast Cancer, 2012, doi:10.1155/2012/147828; Epub article; 11 pages.
  46. Tao, Y.; Ding, Y.; Wan, C.; Li, L.; Xu, J.; Liu, K.; Slitt, A.; Ferreira, D.; Khan, I.A.; Seeram, N.P. Antidiabetic ellagitannins from pomegranate flowers: Inhibition of a-glucosidase and lipogenic gene expression. Organic Letters, 2012, 14, 5358-61.
  47. Seeram, N.P.; Xu, J.; Li, L.; Slitt, A. Mining red maple (Acer rubrum) trees for novel therapeutics to manage diabetes. Medicine and Health Rhode Island, 2012, 95, 283-284.
  48. Omar, R.; Li, L.; Tao, Y.; Seeram, N.P. a-Glucosidase inhibitory hydrolyzable tannins from Eugenia jambolana Journal of Natural Products, 2012, 75, 1505-1509.
  49. Wan, C.; Yuan, T.; Cirello, A.; Seeram, N.P. Antioxidant and a-glucosidase inhibitory phenolics from highbush blueberry flowers. Food Chemistry, 2012, 135, 1929-1937.
  50. Apostolidis, E.; Li, L.; Kang, B.; Lee, C.M.; Seeram, N.P. Seasonal influence on phenolic-mediated antihyperglycemic properties of Canadian sugar and red maple leaves using in vitro assay models. Food Science and Biotechnology, 2012, 3, 753-760.
  51. González-Sarrías, A.; Tao, Y.; Seeram, N.P. Cytotoxicity and structure activity relationship studies of maplexins A-I, gallotannins from red maple (Acer rubrum). Food and Chemical Toxicology, 2012, 50, 1369-1376.
  52. Wan, C.; Yuan, T.; Xie, M.; Seeram, N.P. Acer rubrum phenolics include A-type procyanidins and a chalcone. Biochemical Systematics and Ecology, 2012, 44, 1-3.
  53. Ma, H.; Tao, Y.; González-Sarrías, A.; Li, L.; Edmonds, M.E.; Seeram, N.P. New galloyl derivative from winged sumac (Rhus copallinum) fruit. Natural Products Communications, 2012, 7, 45-46.
  54. Laplante, K.L.; Sarkisian, S. A.; Woodmansee, S.; Rowley, D.C.; Seeram, N.P. Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus Phytotherapy Research, 2012, 26, 1371-1374.
  55. Jean-Gilles, D.; Li, L.; Ma, H.; Yuan, T.; Chichester, C.O.; Seeram, N.P. Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model. Journal of Agricultural and Food Chemistry, 2012, 60, 5755-5762.
  56. Lewis, N.A.; Liu, F.; Seymour, L.; Magnusen, T.; Erves, T.; Arca, F.A.; Beckford,A.; Venkatraman, R.; González-Sarrías, A.; Fronczek, F.R.; VanDerveer, D.G.; Seeram, N.P.; Liu, A.; Jarrett, W.L.; Holder, A.A. Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a schiff base and thiosemicarbazones as mixed-ligands. European Journal of Inorganic Chemistry, 2012, 4, 664-677.
  57. Yuan, T.; Wan, C.; Liu, K.; Seeram, N.P. New maplexins F-I and phenolic glycosides from red maple (Acer rubrum) bark. Tetrahedron, 2012, 68, 959-964.
  58. Wan, C.; Yuan, T.; Li, L.; Kandhi, V.; Cech, N.B.; Xie, M.; Seeram, N.P. Maplexins, new a-glucosidase inhibitors from red maple (Acer rubrum) stems. Bioorganic Medicinal Chemistry Letters, 2012, 22, 597-600.
  59. Beckford, F.; Thessing, J.; Stott, A.; Holder, A. A.; Poluektov, O.G.; Li, L.; Seeram, N.P. Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides. Inorganic Chemistry Communications, 2012, 15, 225-229.
  60. González-Sarrías, A.; Li, L.; Seeram, N.P. Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells. Journal of Functional Foods, 2012, 4, 185-196.
  61. Donepudi, A.C.; Goedken, M.J.; Aleksunes, L.M.; Seeram, N.P.; Slitt, A. The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit) decreases liver inflammation, injury and fibrosis during cholestasis. Liver International, 2012, 32, 560-573.
  62. González-Sarrías, A.; Li, L.; Seeram, N.P. Effects of maple (Acer) plant part extracts on proliferation, apoptosis, and cell cycle arrest of human tumorigenic and non-tumorigenic colon cells. Phytotherapy Research, 2012, 26, 995-1002.
  63. LeBlanc, M-A.; Gonzales-Sarrias, A.; Beckford, F.; Mbarushimana, P.C.; Seeram, N.P. Coordination chemistry of polyaromatic thiosemicarbazones. 2: Synthesis and biological activity of zinc, cobalt and copper complexes of 1-(naphthalene-2-yl)ethanone thiosemicarbazon International Journal of Inorganic Chemistry, 2011, accepted. doi:10.1155/2011/624756.
  64. Apostolidis, E.; Karayannakidis, P.D.; Kwon, Y-I.; Lee, C.M.; Seeram, N.P. Seasonal variation of phenolic antioxidant-mediated a-glucosidase inhibition of Ascophyllum nodosum. Plant Foods for Human Nutrition, 2011, 66, 313-319.
  65. Yuan, T.; Wan, C.; González-Sarrías, A.; Kandhi, V.; Cech, N.B.; Seeram, N.P. Phenolic glycosides from sugar maple (Acer saccharum) bark. Journal of Natural Products, 2011, 74, 2472-2476.
  66. González-Sarrías, A.; Gromek, S.; Niesen, D.; Seeram, N.P.; Henry, G.E. Resveratrol oligomers isolated from Carex species inhibit proliferation of human colon tumorigenic cells inhibited by cell cycle arrest. Journal of Agricultural and Food Chemistry, 2011, 59, 8632-8638.
  67. Ponnala, S.; Chaudhary, S.; González-Sarrías, A.; Seeram, N.P.; Harding, W.W. Cytotoxicity of aporphines in human colon cancer cell lines, HCT-116 and Caco-2: an SAR study. Bioorganic and Medicinal Chemistry Letters, 2011, 21, 4462-4464.
  68. Li, L.; Seeram, N.P. Further investigation into maple syrup yields three new lignans, a new phenylpropanoid, and twenty-six other phytochemicals. Journal of Agricultural and Food Chemistry, 2011, 59, 7708-7716.
  69. Henning, S.M.; Zhang, Y.; Seeram, N.P.; Bowerman, S.; Heber, D. Antioxidant capacity of herbs in dried, fresh, and blended paste forms. International Journal of Food Science and Nutrition, 2011, 62, 219-225.
  70. Beckford, F.A.; Thessing, J.; Shaloski, M.; Mbarushimana, P.C.; Brock, A.; Didion, J.; Woods, J.; González-Sarrías, A.; Seeram, N.P. Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents. Journal of Molecular Structure, 2011, 992, 39-47.
  71. Beckford, F. A.; Thessing, J.; Woods, J.; Didion, J.; Gerasimchuk, N.; González-Sarrías, A.; Seeram, N.P. Synthesis and structure of [(η6p-cymene)Ru(2-anthracen-9 ylmethylene-N-ethylhydrazinecarbothioamide)Cl]Cl: Biological evaluation, topoisomerase-II inhibition and reaction with DNA and human serum albumin. Metallomics, 2011, 3, 491-502.
  72. Beckford, F.A.; Shaloski, ; Thessing, J.; Woods, J.; Dourth, D.; Didion, J.; Gerasimchuk, N.;  González-Sarrías, A.; Seeram, N.P. Half-sandwich ruthenium-arene complexes with thiosemicarbazones: Synthesis and biological evaluation of [(n6p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl. Journal of Inorganic Biochemistry, 2011, 105, 1019-1029.
  73. Apostolidis, E.; Li, L.; Lee, C.M.; Seeram, N.P. In vitro evaluation of phenolic-enriched extracts of maple syrup for inhibition of carbohydrate hydrolyzing enzymes relevant to type 2 diabetes. Journal of Functional Foods, 2011, 3, 100-106.
  74. Li, L.; Seeram, N.P. Quebecol, a novel phenolic compound isolated from Canadian maple syrup. Journal of Functional Foods, 2011, 3, 125-128.
  75. Hong, M-Y.; Henning, S.M.; Moro, A.; Seeram, N.P.; Zhang, Y.; Heber, D. Chinese Red Yeast Rice inhibition of prostate tumor growth in SCID mice. Cancer Prevention Research, 2011, 4, 608-615.
  76. Manning, K.; Petrunak, E.; Lebo, M.; González-Sarrías, A.; Seeram, N.P.; Henry, G.E. Acylphloroglucinols and xanthones from Hypericum ellipticum. Phytochemistry, 2011, 72, 662-667.
  77. Ma, H.; Li, L.; Seeram, N.P. Phenolics from Cornus amomum fruit. Biochemical Systematics and Ecology, 2010, 38, 1083-1084.
  78. Li, L.; Woolridge, D.; Saing, S.R.; Jennings, J.; Henry, G.E.; Seeram, N.P. Flavonoids and a stilbene from Triadenum fraseri (Spach) Gleason. Biochemical Systematics and Ecology, 2010, 38, 1074-1076.
  79. Li, L.; Seeram, N.P. Maple syrup phytochemicals include lignans, coumarins, a stilbene and other previously unreported antioxidant phenolic compounds. Journal of Agricultural and Food Chemistry, 2010, 58, 11673-11679.
  80. Zunino, S.; Zhang, Y.; Seeram, N.P.; Storms, D. Berry fruit extracts inhibit growth and induce apoptosis of high risk acute lymphoblastic leukemia cells in vitro. Journal of Functional Foods, 2010, 2, 185-195.
  81. Adams, L.S.; Phung, S.; Yee, N.; Seeram, N.P.; Li, L.; Chen, S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol-3-kinase pathway. Cancer Research, 2010, 70, 3594-605.
  82. Sharma, M.; Li, L.; Celver, J.; Killian, C.; Kovoor, A.; Seeram, N.P. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. Journal of Agricultural and Food Chemistry, 2010, 58, 3965-3969.
  83. Koyama, S.; Cobb, L.J.; Mehta, H.H.; Seeram, N.P.; Heber, D.; Pantuck, A.J.; Cohen P. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Hormone IGF Research, 2010, 20, 55-62.
  84. Adams, L.S.; Zhang, Y.; Seeram, N.P.; Heber, D.; Chen. S. Pomegranate ellagitannin derived compounds exhibit anti-proliferative and anti-aromatase activities in breast cancer cells in vitro. Cancer Prevention Research, 2010, 3,108-113.
  85. Henning, S.M.; Seeram, N.P.; Zhang, Y.; Li, L.; Gao, K.; Lee, R.; Wang, D.C.; Zerlin, A.; Karp, H.; Thames, G.; Kotlerman, J.; Li, Z.; Heber, D. Strawberry consumption is associated with increased antioxidant capacity in serum. Journal of Medicinal Foods, 2010, 13, 116-122.
  86. Beckford, F.; Leblanc, G.; Thessing, J.; Shaloski, M.; Frost, B.J.; Li, L.; Seeram, N.P. Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(6-p-cymene)Ru(NS)Cl]+ (NS = 9-anthraldehyde thiosemicarbazones). Inorganic Chemistry Communications, 2009, 12, 1094-1098
  87. Beckford, F.; Shaloski, M.; Leblanc, G.; Thessing, J.; Lewis -Alleyne, L.C.; Holder,A. A.; Li, L.; Seeram, N.P. Microwave synthesis of mixed ligand diimine-thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicity. Dalton Transactions, 2009, 48, 10757-10764.
  88. Henry, G.E.; Campbell, M.; Zelinsky, A.A.; Liu, Y.; Bowen-Forbes, C.S.; Li, L.; Nair, M.G.; Rowley, D.C.; Seeram, N.P. Bioactive acylphloroglucinols from Hypericum densiflorum. Phytotherapy Research, 2009, 23, 1759-1762.
  89. Li, L.; Henry G.E.; Seeram, N.P. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata Journal of Agricultural and Food Chemistry, 2009, 57, 7282-7287.
  90. Zunino, S.J.; Storms, D.H.; Zhang, Y.; Seeram, N.P. Growth arrest and induction of apoptosis in high-risk leukemia cells by strawberry components. Journal of Functional Foods, 2009, 1, 153-160.
  91. Zhang, Y.; Krueger, D.; Durst, R.; Lee, R.; Wang, D.; Seeram, N.P.; Heber, D. International Multidimensional Authenticity Specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration. Journal of Agricultural and Food Chemistry, 2009, 57, 2550-2557.
  92. Li, L.; Zhang, Y.; Seeram, N.P. Structure of anthocyanins from Eugenia jambolana Natural Products Communications, 2009, 4, 217-219.
  93. Li, L.; Adams, L.S.; Chen, S.; Killian, C.; Ahmed, A.; Seeram, N.P. Eugenia jambolana berry extract inhibits proliferation and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. Journal of Agricultural and Food Chemistry, 2009, 57,826-831.
  94. Sathe, S.K.; Seeram, N.P.; Kshirsagar H.H.; Heber, D.; Lapsley, K.A. Fatty acid composition of California grown almonds. Journal of Food Sciences, 2008, 73, C607-14.
  95. Hong, M.Y.; Seeram, N.P.; Zhang, Y.; Heber, D. Chinese Red Yeast Rice vs. Lovastatin effects on prostate cancer cells with and without androgen receptor overexpression. Journal of Medicinal Foods, 2008, 11, 657-666.
  96. Hong, M.Y.; Seeram, N.P.; Heber, D. Pomegranate polyphenols downregulate expression of androgen synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. Journal of Nutritional Biochemistry, 2008, 19, 848-55.
  97. Hong, M.Y.; Seeram, N.P.; Zhang, Y.; Heber, D. Anticancer effects of Chinese Red Yeast Rice versus monacolin alone on colon cancer cells. Journal of Nutritional Biochemistry, 2008, 19, 448-458.
  98. Rettig, M.B.; Heber, D.; An, J.; Seeram, N.P.; Liu, H.; Rao, J.Y.; Liu, H.; Klatte, T.; Belldegrun, A.; Moro, A.; Henning, S.M.; Mo, D.; Aronson, W.J.; Pantuck, A.J. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-Kb-dependent mechanism. Molecular Cancer Therapeutics, 2008, 7, 2662-2671.
  99. Seeram, N.P.; Zhang, Y.; McKeever, R.; Henning, S.M.; Lee, R.; Sartippour, M.; Suchard, M.A.; Li, Z.; Chen, S.; Thames, G.; Zerlin, A.; Nguyen, M.; Wong, D. Heber, D. Ellagitannin metabolites are present in human plasma and urine in similar levels after consumption of pomegranate fruit juice and its liquid and solid extracts. Journal of Medicinal Foods, 2008, 11, 390-394.
  100. Seeram, N.P.; Aviram M.; Zhang, Y.; Henning, S.M.; Dreher, M.; Heber, D. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. Journal of Agricultural and Food Chemistry, 2008, 56, 1415-1422. (Most accessed article for year 2008 in the Journal of Agricultural and Food Chemistry).
  101. Zhang, Y.; Seeram, N.P.; Lee, R.; Feng, L.; Heber, D. Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative activities. Journal of Agricultural and Food Chemistry, 2008, 56, 670-675. (Most accessed article for Jan-Mar 2008 in the Journal of Agricultural and Food Chemistry).
  102. Sartippour, M.; Seeram, N.P.; Rao, J.Y.; Moro, A.; Harris, D.M.; Firozi, A.; Rettig, M.; Aronson, W.J.; Pantuck, A.J.; Heber, D. Ellagitannin-rich pomegranate extract inhibit angiogenesis in prostate cancer in vitro and in vivo. International Journal of Oncology, 2008, 32, 475-80.
  103. Venkatachalam, M.; Kshirsagar H.H.; Seeram, N.P.; Heber, D.; Thompson, T.T.; Roux, K.H.; Sathe, S.K. Biochemical composition and immunological comparison of select pecan [Carya illinoinensis (Wangenh.) K. Koch] cultivars. Journal of Agricultural and Food Chemistry, 2007, 55, 9899-07.
  104. Heber, D.; Seeram, N.P; Wyatt, H.; Henning, S.M.; Zhang, Y.; Ogden, L.G.; Dreher, M.; Hill, J.O. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol extract dietary supplement in overweight individuals with increased waist size. Journal of Agricultural and Food Chemistry, 2007, 55, 10050-10054.
  105. Seeram, N.P.; Aronson, W.J.; Zhang, Y.; Henning, S.M.; Moro, A.; Lee, R.; Sartippour, M.; Harris, D.M.; Rettig, M.B.; Suchard, M.A.; Pantuck, A.J.; Belldegrun, A.; Heber, D. Pomegranate ellagitannin derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. Journal of Agricultural and Food Chemistry, 2007, 55, 7777-7785. (Most accessed article for Oct-Dec 2007 in the Journal of Agricultural and Food Chemistry)
  106. Bobe, G.; Wang, B.; Seeram, N.P.; Nair, M.G.; Bourquin. L.D. Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APCMin mice fed suboptimal levels of sulindac.  Journal of Agricultural and Food Chemistry 2006, 54, 9322-9328.
  107. Seeram, N.P.; Adams, L.S; Zhang, Y; Sand, D.; Heber, D. Blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. Journal of Agricultural and Food Chemistry, 2006, 54, 9329-39. (Most accessed article for Oct-Dec 2006 in the Journal of Agricultural and Food Chemistry)
  108. Li, Z.; Seeram, N.P.; Carpenter, C.; Thames, G.; Minutti, C.; Bowerman, S. Effect of cranberry on INR in subjects on warfarin for atrial fibrillation. Journal of American Dietetic Association, 2006, 106, 2057-2061.
  109. Henry, G.E.; Raithore, S.; Zhang, Y.; Jayaprakasam B.; Nair, M.G.; Heber, D.; Seeram, N.P. Acylphloroglucinol derivatives from Hypericum prolificum. Journal of Natural Products, 2006, 69, 1645-1648.
  110. Henry, G.E.; Adams, L.S.; Rosales, J.C.; Jacobs, H.; Heber, D.; Seeram, N.P. Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cell lines in vitro.   Cancer Letters, 2006, 244, 190-194.
  111. Seeram, N.P.; Henning, S.M.; Zhang, Y.; Suchard, M.; Li, Z.; Heber D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. Journal of Nutrition, 2006,136, 2481-2485.
  112. Seeram, N.P.; Zhang, Y.; Henning, S.M.; Lee, R.; Niu, Y.; Lin, G.; Heber D. Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative properties. Journal of Agricultural and Food Chemistry, 2006, 54, 7036-7040.
  113. Kobayashi, N.; Barnard, R.J.; Henning, S.H.; Elashoff, D.; Reddy, S.T.; Cohen, P.; Leung, P.; Hong-Gonzalez, J.; Freedland, S.J.; Said, J.; Gui, D.; Seeram, N.P.; Popoviciu, L.M.; Bagga, D.; Heber, D.; Glaspy, J.A.; Aronson, W.J. Effect of altering dietary omega-6:omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2 and prostaglandin E-2. Clinical Cancer Research, 2006, 12, 4662-4670.
  114. Sarafian, T.; Habib, N.; Oldham, M.; Seeram, N.P.; Lee, R.; Tashkin, D.P.; Roth, M.D. Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006, 290, L1202-209.
  115. Muller, C.I.; Kumagai T.; Kelly, J.O.; Seeram, N.P.; Heber, D.; Koeffler, P.H. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leukemia Research, 2006, 30, 841-848.
  116. Pantuck, A.J.; Leppert, J.T.; Zomorodian, N.; Aronson, W.; Hong, J.; Barnard, R.J.; Seeram, N.P.; Liker, H.; Wang, H-E.; Elashoff, R.; Heber, D.; Aviram, M.; Ignarro, L.; Belldegrun, A. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clinical Cancer Research, 2006, 12, 4018-4026.
  117. Henning, S.M.; Aronson, W.; Niu, Y.; Conde, F.; Lee, N.H.; Seeram, N.P.; Lee, R.; Lu, J.; Harris, D.M.; Moro, A.; Hong, J.; Pak-Shan, L.; Barnard, R.J.; Ziaee, H.G.; Csathy, G.; Go, V.L.W.; Wang, H.; Heber, D. Bioavailability and bioactivity of tea polyphenols in human and mice prostate tissue and serum after green and black tea consumption. Journal of Nutrition, 2006, 136, 1839-1843.
  118. Seeram, N.P.; Henning S.M.; Lee, R.; Niu Y.; Scheuller, H.S.; Heber, D. Catechin and caffeine contents of green tea dietary supplements and correlation with antioxidant activity. Journal of Agricultural and Food Chemistry, 2006, 54, 1599-1603. (Most accessed article for year 2006 in the Journal of Agricultural and Food Chemistry).
  119. Adams, L.S.; Seeram, N.P.; Hardy, M.L.; Carpenter, C.; Heber, D. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cells. Evidence-Based Complementary and Alternative Medicine, 2006, 3, 117-124.
  120. Adams, L.S.; Seeram, N.P.; Aggarwal, B.B.; Takada, Y.; Sand, D.; Heber, D. Pomegranate juice, total pomegranate tannins and punicalagin suppress inflammatory cell signaling in colon cancer cells. Journal of Agricultural and Food Chemistry, 2006, 54, 980-985. [Cited as ACS (American Chemical Society) Hot Papers: May 2007; As defined by Thomson ISI®’s Essential Science Indicators, Hot Papers are articles published within the last 2 years receiving the most citations over the most recent 2-month period].
  121. Gao, K.; Xu, A.; Krull, C.; Venema, K.; Liu, Y.; Niu Y.; Lu, J.; Bensoussan, L.; Seeram, N.P.; Heber D.; Henning S.M. Of the major phenolic acids formed during human microbial fermentation of tea, citrus and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity. Journal of Nutrition, 2006, 136, 52-57.
  122. Gao, K.; Henning, S.M.; Niu, Y.; Bensoussan, L.; Seeram, N.P.; Xu. A.; Heber, D. The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. Journal of Nutritional Biochemistry, 2006, 17, 89-95.
  123. Seeram, N.P.; Lee, R.; Scheuller, H.S.; Heber, D. Identification of phenolics in strawberries by liquid chromatography electrospray ionization mass spectroscopy. Food Chemistry, 2006, 97, 1-11.
  124. Li, Z.; Seeram, N.P.; Lee, R.; Thames, G.; Minutti, C.; Wang, H-J.; Heber, D. Plasma clearance of Lovastatin vs. Chinese Red Yeast Rice in healthy volunteers. Journal of Alternative and Complementary Medicine, 2005, 11, 1031-1038.
  125. Loren, D.; Seeram, N.P.; Schulman, R.N.; Holtzman, D. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatric Research, 2005, 57, 858-864.
  126. Seeram, N.P.; Adams, L.S.; Henning, S.M.; Niu, Y.; Zhang, Y.; Nair, M.G.; Heber, D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. Journal of Nutritional Biochemistry, 2005,16, 360-367.
  127. Seeram, N.P.; Lee, R.; Hardy, M.L.; Heber, D. Rapid large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry. Separation and Purification Technology, 2005, 41, 49-55.
  128. Sartippour, M.R.; Seeram, N.P.; Heber, D.; Hardy, M.L.; Norris, N.; Lu, Q.L.; Zhang L.; Rao, J.Y.; Brooks, M.N. Rabdosia rubescens inhibits breast cancer growth and angiogenesis. International Journal of Oncology, 2005, 26, 121-127.
  129. Seeram, N.P.; Lee, R.; Heber, D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum) juice. Clinica Chimica Acta, 2004, 348, 63-68.
  130. Tall, J.M.; Seeram, N.P.; Zhao, C.; Nair, M.G.; Meyer, R.A.; Raja, S.N. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behavioral Brain Research, 2004, 153, 181-88.
  131. Seeram, N.P.; Adams, L.S.; Hardy, M.L.; Heber, D. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. Journal of Agricultural and Food Chemistry, 2004, 52, 2512-2517.
  132. Beckwith, A.G.; Zhang, Y.; Seeram, N.P.; Cameron, A.C.; Nair, M.G. Relationship of light quantity and anthocyanin production in Pennisetum setaceum Rubrum and Red Riding Hood. Journal of Agricultural and Food Chemistry, 2004, 52, 456-461.
  133. Zhang, Y.; Bolleddula, J.; Seeram, N.P.; Olsen, L.K.; Dewitt, D.; Nair, M.G. Insulin secretion and cyclooxygenase enzyme inhibition by Cabernet Sauvignon grape skin compounds. Journal of Agricultural and Food Chemistry, 2004, 52, 228-233.
  134. Cichewicz, R.H.; Zhang, Y.; Seeram, N.P.; Nair, M.G. Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies. Life Sciences, 2004, 74, 1791-1799.
  135. Bolleddula, J.; Zhang, Y.; Seeram, N.P.; Nair, M.G. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera Life Sciences, 2003, 174, 125-132.
  136. Kang, S.Y.; Seeram, N.P.; Nair, M.G.; Bourquin, L.D. Tart cherry anthocyanins inhibit tumor development in ApcMin mice and reduce proliferation of human colon cancer cells. Cancer Letters, 2003, 194, 13-19.
  137. Seeram, N.P.; Zhang, Y.; Nair, M.G. Inhibition of proliferation of human cancer cell lines and cyclooxygenase enzymes by anthocyanidins and catechins. Nutrition and Cancer, 2003, 46, 101-106.
  138. Seeram, N.P.; Cichewicz, R.H.; Chandra, A.; Nair, M.G. Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. Journal of Agricultural and Food Chemistry, 2003, 51, 1948-1951.
  139. Bolleddula, J.; Seeram, N.P.; Nair, M.G. Anticancer and anti-inflammatory activities of  cucurbitacins from Cucurbita andreana. Cancer Letters, 2003, 189, 11-16.
  140. Seeram, N.P.; Francis, L.S.; Needham, O.L.; Jacobs, H.; McLean, S.; Reynolds, W.F. Drimane and bisabolane sesquiterpenoids from Cinnamodendron corticosum (Canellaceae). Biochemical Systematics and Ecology, 2002, 31, 637-640.
  141. Seeram, N.P.; Nair, M.G. Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents, anthocyanins, anthocyanidins and catechins. Journal of Agricultural and Food Chemistry, 2002, 50, 5308-5312.
  142. Seeram, N.P.; Schutzki, R.; Chandra, A.; Nair, M.G. Characterization, quantification and bioactivities of anthocyanins in Cornus Journal of Agricultural and Food Chemistry, 2002, 50, 2519-2523.
  143. Seeram, N.P.; Bourquin, L.D.; Nair, M.G. Degradation products of cyanidin glycosides from tart cherries and their bioactivities. Journal of Agricultural and Food Chemistry, 2001, 49, 4924-4929.
  144. Seeram, N.P.; Momin, R.A.; Bourquin, L.D.; Nair, M.G. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides from cherries and berries. Phytomedicine, 2001, 8, 362-369.
  145. Jacobs, H.; Seeram, N.P.; Nair, M.G.; McLean, S.; Reynolds, W.F. Amides of Piper amalago nigrinodum. Journal of Indian Chemical Society, 2000, 76, 713-717.
  146. Seeram, N.P.; Lewis, A.; Jacobs, H.; Nair, M.G.; McLean, S.; Reynolds, W.F. Proctoriones A-C: 2-acylcyclohexane-1,3-dione derivatives from Peperomia proctorii. Journal of Natural Products, 2000, 63, 399-402.
  147. Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F. A prenylated benzopyran derivative from Peperomia clusiifolia. Phytochemistry, 1998, 49, 1389-1391.
  148. Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F. Prenylated hydroxybenzoic derivatives from Piper murrayanum. Phytochemistry, 1996, 43, 863-865.
  149. Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F.; Tay, L.; Wu, M. 3,4-epoxydihydropiplartine, A new imide from Piper verrucosum. Journal of Natural Products, 1996, 59, 436-437.

 

Review & Symposium Introduction Articles in Peer-Reviewed Journals

  1. Seeram, N.P.; Shukitt-Hale, B. Advances in Berry Research: The Sixth Biennial Berry Health Benefits Symposium. Journal of Berry Research, 2016, 16, 93-95.
  2. Seeram, N.P. Berries and Human Health: Research Highlights from the Fifth Biennial Berry Health Benefits Symposium, Journal of Agricultural and Food Chemistry, 2014, 62, 3839-3841.
  3. Niesen, D.; Hessler, C.; Seeram, N.P. Beyond Resveratrol: A Review of Natural Stilbenoids Identified From 2009-2013. Journal of Berry Research, 2013, 3, 181-196. (Invited Review).
  4. Seeram, N.P. Emerging research supporting the positive effects of berries on human health and disease prevention. Journal of Agricultural and Food Chemistry, 2012, 60, 5685-5686.
  5. Seeram, N.P. Recent trends and advances in berry health benefits research. Journal of Agricultural and Food Chemistry, 2010, 58, 3869-3870.
  6. Seeram, N.P. Berry Fruits: Compositional elements, biochemical activities and the impact of their intake on human health, performance and disease. Journal of Agricultural and Food Chemistry, 2008, 56, 627-629. (Most accessed article for year 2008 in the Journal of Agricultural and Food Chemistry).
  7. Seeram, N.P. Berry fruits for cancer prevention: Current status and future prospects. Journal of Agricultural and Food Chemistry, 2008, 56, 630-635. (Most accessed article for Jan-Mar 2008 in the Journal of Agricultural and Food Chemistry).
  8. Aggarwal, B.B.; Bhardwaj, A.; Aggarwal, R.S.; Seeram, N.P.; Shishodia, S.; Takada, Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research, 2004, 24, 2783-2840. (Invited Review).

 

Book Chapters

  1. Yuan, T. and Seeram, N.P. Pomegranate Juice, Chapter 42, pp. 513-526, In: Handbook of Functional Beverages and Human Health, Alasalvar, C.; Shahidi, F. (Eds). CRC Press, Boca Raton, FL, USA, 2016. Print ISBN: 978-1-4665-9641-2. eBook ISBN: 978-1-4665-9642-9.
  2. Yuan, T. and Seeram, N.P. Maple Water, Chapter 58, pp. 757-764, In: Handbook of Functional Beverages and Human Health, Alasalvar, C.; Shahidi, F. (Eds). CRC Press, Boca Raton, FL, USA, 2016. Print ISBN: 978-1-4665-9641-2. eBook ISBN: 978-1-4665-9642-9.
  3. Do, Q.T.; Driscoll, M.; Slitt, A.; Seeram, N.; Peppard, T.; Bernard, P. Reverse pharmacognosy: A tool to accelerate discovery of new bioactive food ingredients. In: Foodinformatics, Martinez-Mayorga, K.; Medina-Franco, J.L. (Eds), Springer International Publishing, pp.111-130, 2014. doi: 10.1007/978-3-319-10226-9_4; ISBN: 978-3-319-10225-2.
  4. Li, L.; Seeram, N.P. Chemical composition and biological effects of maple syrup. Chapter 18, pp. 323-333. American Chemical Society (ACS) Symposium Series Volume 1093, In Emerging Trends in Dietary Components for Preventing and Combating Disease, Patil, B.; Murthy, K.N.C.; Jayaprakasha, G.K.; Seeram, N.P. (Eds), Oxford University Press, Washington DC, USA, 2012.
  5. Seeram, N.P. Polyphenol overview. In: Encyclopedia of Dietary Supplements. Coates, P.; Betz,  M.; Blackman, M.R.; Cragg, G.M.; Levine, M.; Moss, J.; White, J.D. (Eds.). Informa Healthcare, New York, NY, USA, 2010, p.632.
  6. Seeram, N.P.; Zhang, Y.; Bowerman, S.; Heber, D. Phytochemicals and health aspects of the pistachio. In: Tree Nut Nutraceuticals, Phytochemicals, and Health Aspects. Alasalvar, C.; Shahidi, F. (Eds). CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, 2009, pp. 295-304.
  7. Seeram, N.P. Strawberry phytochemicals and human health: A review. In: Takeda, F., D.T. Handley, and E.B. Poling (Eds.). Proceedings of the 2007 North American Strawberry Symposium.  North American Strawberry Growers Association, Kemptville, ON, Canada, 2008. pp. 7-14.
  8. Seeram, N.P.; Heber, D. Impact of berry phytochemicals on human health: Effects beyond antioxidation. Chapter 21. In: Lipid Oxidation and Antioxidants: Chemistry, Methodologies and Health Effects. American Chemical Society (ACS) Symposium Series No.956/Antioxidant Measurement and Applications; Ho, C.T; Shahidi, F.S. (Eds). Oxford University Press, UK, 2006.
  9. Aggarwal, B.B.; Bhatt, I.D.; Ichikawa, H.; Ahn, K.S.; Sethi, G.; Sandur, S.K.; Natarajan, C.; Seeram, N.P.; Shishodia, S. Curcumin: Biological and medicinal properties. Chapter 10, pp. 297-368. In: Turmeric: The genus Curcuma. Ravindran, P.N.; Babu, K.N.; Sivaraman, K. (Eds.) CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  10. Seeram, N.P.; Zhang, Y.; Reed, J; Krueger, C.; Vaya, J. Pomegranate phytochemicals. Chapter 1, 3-30. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  11. Espin, C.; Seeram, N.P.; Tomás-Barberán, F.A. Bioavailability of pomegranate polyphenols. Chapter 3, pp. 45-60. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  12. Harris, D.M.; Besselink, E.; Seeram, N.P. Assessment of estrogenicity of pomegranate in an in vitro bioassay. Chapter 9, pp. 143-155. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal &Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  13. Seeram, N.P.; Zhang, Y.; Heber, D. Commercialization of pomegranates: Fresh fruits, beverages and botanical extracts. Chapter 12, pp. 187-196. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  14. Seeram, N.P. Berries. Chapter 37, pp. 615-625. In: Nutritional Oncology. Second Edition. Heber, D.; Blackburn, G.; Go, V.L.W.; Milner, J. (Eds). Academic Press, London, UK, 2006.
  15. Seeram, P. Bioactive polyphenols from foods and dietary supplements: Challenges and opportunities. Chapter 3, pp. 25-38; In: Herbs: Challenges in Chemistry and Biology; ACS Symposium Series No. 925 (Herbs); Ho, C.T; Wang, M.; Sang, S. (Eds). Oxford University Press, UK, 2006.
  16. Seeram, N.P.; Kulkarni, V.V.; Padhye, S. Sources and chemistry of resveratrol. Chapter 2, p. 17. In: Oxidative Stress and Diseases Series: Resveratrol in Health and Disease. Aggarwal, B.B.; Shishodia, S.; Packer, L. (Eds). Taylor & Francis Group, Boca Raton, FL, USA, 2006.
  17. Seeram, N.P.; Ichikawa, H.; Shishodia, S.; Aggarwal, B.B. Preventative and therapeutic effects of plant polyphenols through suppression of nuclear factor-kappa B. Chapter 21, pp. 243-275. In: Oxidative Stress and Diseases Series: Molecular Intervention in Lifestyle-Related Diseases. Hiramatsu, M.; Yoshikawa, T.; Packer, L. (Eds). CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, 2006.

 

Book Editor & Book Series Editor

  1. Patil, B.; Murthy, K.N.C.; Jayaprakasha, G.K.; Seeram, N.P. (Eds). American Chemical Society (ACS) Symposium Series, Emerging Trends in Dietary Components for Preventing and Combating Disease, American Chemical Society, Washington DC, distributed by Oxford University Press, 2012.
  2. Stoner, G.; Seeram, N.P. (Eds). Berries and Cancer. Springer Science, NY, USA, 2011.
  3. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). Pomegranates: Ancient Roots Modern Medicine. CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  4. Seeram, N.P. Founding Editor of Clinical Pharmacognosy Series; CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, August 2008. Three volumes published in this series to date.

 

Honors and Awards

Thomson Reuters Highly Cited Researcher in Agricultural Sciences in 2014 and 2015 (based on papers indexed in Web of Science from 2002-2015).

Editorial Boards of Journal of Agricultural and Food Chemistry, International Journal of Applied Research in Natural Products, Journal of Berry Research.

Advisory Board of the American Botanical Council.

2009 Young Scientist Award, Division of Agricultural and Food Chemistry, American Chemical Society.

Copyright © 2017 University of Rhode Island.

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