College of Pharmacy

7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.edu – Office: 401.874.2761 Fax: 401.874.2181

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Bingfang Yan, D.V.M., Ph.D.

bingfang_yan_web
  • BPS Department Chair and Professor
  • Office: 395B Lab: 360
  • Phone: 401.874.5032
  • Email: byan@uri.edu
  • Mailing Address: 7 Greenhouse Road, Kingston, RI 02881

Biography

researchwebsiteThe primary focus of my research is on the understanding of how genetic and environmental factors coordinately regulate the expression of genes involved in drug response and oncogenic switch. The work from this laboratory has been well cited with several original research papers being cited more than 100 times. Several research findings were reported by multiple media outlets such as USA Today and Doctor Guide. Dr. Yan is an author of Encyclopedia of Drug Metabolism and Interactions. This book has six volumes, represents a global effort, and presents more than 120 chapters by prominent authors from 11 different countries: USA, Canada, UK, Germany, Australia, Singapore, India, Japan, France, Denmark, and Switzerland.

In the past decade, the research activities are designed to answer such questions as: how does genetic or environmental factor contribute to differences in drug-response? How does transcriptional regulation switch from physiological (e.g., drug-metabolism) to pathological response (oncogenesis)? And how do drugs, hormones and herbs alter therapeutic activity when used together? In recent years, this laboratory has been focusing four projects: (Project 1) Molecular Biology of Carboxylesterases; (Project 2) Signaling of the Pregnane X receptor; (Project 3) Functional Characterization of DEC Transcription Factors; (Project 4) Herb-Drug Interactions

Research

Genetic-based alterations on drug response; Drugs, herbs, hormones, and their interactions; Cancer: initiation, progression and chemoresistance

Education

Ph.D., University of Kansas Medical Center Department of Pharmacology, Toxicology and Therapeutics, 1994

Postdoctoral Fellow, University of Kansas Medical Center Department of Pharmacology, Toxicology and Therapeutics, 1989-1991

Postdoctoral Fellow, New York Medical College Department of Microbiology and Immunology, 1988-1989

M.S., Nanjing Agricultural University Department of Microbiology and Immunology, School of Veterinary Medicine, 1985

D.V.M., Huazhong Agricultural University School of Veterinary Medicine, 1982

Publications

Xiao D, Yang D, Guo L, Lu W, Charpentier M, Yan B (2013) Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anticancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. Brit J Pharmacol. 168,1989-1999.

Song X, Chen Y, Valanejad L, Kaimal R, Stoner M, Yan B, Deng R (2013) Mechanistic Insights into Isoform-dependent and Species-specific Regulation of Bile Salt Export Pump by Farnesoid X Receptor. J Lipid Res. 54, 3030-3044.

Guo L, Panderi I, Yan D, Szulak K, Li Y, Chen YT, Ma H, Niesen D, Seeram NP, Ahmed A, Yan B, Pantazato D, Lu W (2013) A comparative study of hollow CuS nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano. 7,8780-8793.

Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B (2013) Carboxylesterase-2 is a highly sensitive target of the anti­obesity agent orlistat with profound clinical implications in the activation of anticancer prodrugs. Biochem Pharmacol. 85, 439–447.

Chen Y, Song X, Vasilenko A, Valanejad L, More V, Qiu X, Chen W, Lai Y, Slitt A, Stoner M, Yan B, Deng R (2013) Bile salt export pump is dysregulated with altered farnesoid x receptor isoform expression in patients with hepatocellular carcinoma tissues. Hepatology. 57, 1530-1541.

Mao Z, Luan X, Cao G, Liu W, Xiong J, Hu G, Chen R, Ning R, Shang W, Yang J, Yan B (2012) DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol. 84, 701-711.

Ramadan S, Guo L, Li Y, Yan B, Lu W (2012) Hollow copper sulfide nanoparticle-mediated transdermal drug delivery. Small. 8, 3143-3150.

Chen YZ, Shi D, Yang D, Yan B (2012) Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2. Biochem Pharmacol. 84, 864-871.

Yang D, Yang J, Shi D, Xiao D, Chen YT, Black C, Deng R, Yan B (2012) The hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of cholesterylester hydrolase CES1 and bile salt export pump. J Lipid Res. 53, 529-539.

Xiao D, Chen YZ, Yang D, Yan B (2012) Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation. Biochem Pharmacol. 84, 232-239.

Yang D, Shi D, Yang J, Deng R, Yan B (2011) Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor. Brit J Pharmacol. 164, 1547-1557.

Mao Z, Li Y, Peng Y, Luan X, Gui H, Feng X, Hu G, Shen J, Yan B, Yang J (2011)Lipopolysaccharide down-regulates carboxylesterases 1 and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-κB pathway. Toxicol Lett. 201, 213-220.

Dostalek M, Court MH, Yan B, Akhaghi F (2011) Significantly reduced cytochrome P4503A4 expression and activity in liver from human with diabetes mellitus. Brit J Pharmacol. 163, 937-947.

Shi D, Yang D, Prinssen EP, Brian E. Davies BE, Yan B (2011) Surge in expression of carboxylesterase-1 during the post-natal stage enables a rapid gain of the capacity to activate the anti-influenza prodrug oseltamivir. J Infect Dis. 203, 937-942.

Yang J, Luan X, Gui H, Yan P, Yang D, Song X, Liu W, Hu G, Yan B Byakangelicin induces cytochrome P450 3A4 expression via transactivation of the pregnant X receptor in human hepatocytes. Brit J Pharmacol. 162, 441-451.

Li Y, Shen Q, Kim HT, Bissonnette RP, Lamph WW, Yan B, Brown PH (2011) The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor. Breast Cancer Res Treat.  128, 667-677.

Yang J, Hao C, Yang D, Shi D, Song X, Luan X, Hu G, Yan B (2010) Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes. Toxicol Lett. 197, 219-226.

Shi D, Yang D, Yan B (2010) Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid deltamethrin in the induction of cytochrome P450 3A23. Biochem Pharmacol. 80, 1274-1283.

Xiao Y, Xu W, Yan B, Yang D, Yang J, He X, Liang S, Hu X (2009) Preparation and Characterization of a Novel Pachyman-Based Pharmaceutical Aid II. A pH-Sensitive, Biodegradable and Biocompatible Hydrogel for Controlled Release of Protein Drugs. Carbohyd Polym. 77, 612-620.

Kaimal R, Song X, Yan B, King R, Deng R (2009) Differential modulation of farnesoid X receptor signaling pathway by the thiazolidinediones. J Pharmacol Exp Ther. 330, 125-134.

Yang D, Wang X, Chen YT, Deng R, Yan B (2009) Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. Toxicol Appl Pharmacol. 237, 49-58.

Yang D, Pearce R, Wang X, Roger Gaedigk, Wan YJY, Yan B (2009) Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochem Pharmacol. 77, 238 – 247.

Shi D, Yang J, Yang D, You L, Yan B (2008) Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: evidence for an involvement of the glucocorticoid receptor. Toxicology. 254, 97-105.

Song X, Kaimal R, Yan B, Deng R (2008) Liver receptor homolog-1 up-regulates the expression of human bile salt export pump and evidence for the species-dependent up-regulation. J Lipid Res. 49, 973-984.

Qian Y, Zhang J, Yan B, Chen X (2008) DEC1, a bHLH transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem. 283, 2896-2905.

Liu F, Yang D, Song X, Deng R, Yan B (2008) The far and distal enhancers in the CYP3A4 gene coordinates the proximal promoter in responding to the pregnane X receptor similarly but differentially to hepatocyte nuclear factor-4α. Biochem J. 409, 243-250.

Patel CG, Richman K, Yang D, Yan B, Gohh RY, Akhlaghi F (2007) Effect of diabetes on mycophenolic acid concentration and inosine monophosphate dehydrogenase activity in kidney transplant recipients. Ther Drug Monit. 29, 735-742.

Yang J, Shi D, Yang D, Song X, Yan B (2007) Interleukin-6 suppresses the expression of carboxyl­ esterases HCE1 and HCE2 through transcriptional repression. Mol Pharmacol. 72, 686-694.

Deng R, Yang D, Radke A, Yang J, Yan B (2007) Hypolipidemic agent guggulsterone regulates BSEP expression: dominance of transactivation over FXR- antagonism. J Pharmacol Exp Ther. 320, 1153-1162.

Yang J, Yan B (2007) Photochemotherapeutic agent 8-methoxypsoralen induces the expression of cytochrome P450 3A4 and carboxylesterase HCE2: evidence on a differential involvement of the pregnane X receptor. Toxicol Sci. 95, 13-22.

Li Y, Bi Z, Yan B, Wan Y (2006) UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway. Int J Mol Med. 18, 713-719.

Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL Black C, Yang D, Shi, D, Yan B (2006) Anti-platelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases and clopidogrel is transesterificated in the presence of ethyl alcohol. J Pharmacol Exp Ther. 319, 1467-1476.

Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B (2006) Anti-influenza prodrug oseltamivir is activated by carboxylesterase HCE1 and the activation is inhibited by anti-platelet agent clopidogrel. J Pharmacol Exp Ther. 319, 1477-1484.

Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2006) The expression of antiapoptotic protein survivin is trans­criptionally upregulated by DEC1 primarily through multiple Sp1 binding sites in the proximal promoter. Oncogene. 25, 3296-3306.

Deng R, Yang D, Yang J, Yan B (2006) Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. J Pharmacol Exp Ther. 317, 317-325.

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