- BPS Department Chair and Professor
- Office: 395B Lab: 360
- Phone: 401.874.5032
- Email: email@example.com
- Mailing Address: 7 Greenhouse Road, Kingston, RI 02881
The primary focus of my research is on the understanding of how genetic and environmental factors coordinately regulate the expression of genes involved in drug response and oncogenic switch. The work from this laboratory has been well cited with several original research papers being cited more than 100 times. Several research findings were reported by multiple media outlets such as USA Today and Doctor Guide. Dr. Yan is an author of Encyclopedia of Drug Metabolism and Interactions. This book has six volumes, represents a global effort, and presents more than 120 chapters by prominent authors from 11 different countries: USA, Canada, UK, Germany, Australia, Singapore, India, Japan, France, Denmark, and Switzerland.
In the past decade, the research activities are designed to answer such questions as: how does genetic or environmental factor contribute to differences in drug-response? How does transcriptional regulation switch from physiological (e.g., drug-metabolism) to pathological response (oncogenesis)? And how do drugs, hormones and herbs alter therapeutic activity when used together? In recent years, this laboratory has been focusing four projects: (Project 1) Molecular Biology of Carboxylesterases; (Project 2) Signaling of the Pregnane X receptor; (Project 3) Functional Characterization of DEC Transcription Factors; (Project 4) Herb-Drug Interactions
Genetic-based alterations on drug response; Drugs, herbs, hormones, and their interactions; Cancer: initiation, progression and chemoresistance
Ph.D., University of Kansas Medical Center Department of Pharmacology, Toxicology and Therapeutics, 1994
Postdoctoral Fellow, University of Kansas Medical Center Department of Pharmacology, Toxicology and Therapeutics, 1989-1991
Postdoctoral Fellow, New York Medical College Department of Microbiology and Immunology, 1988-1989
M.S., Nanjing Agricultural University Department of Microbiology and Immunology, School of Veterinary Medicine, 1985
D.V.M., Huazhong Agricultural University School of Veterinary Medicine, 1982
Yang D, Pearce R, Wang X, Roger Gaedigk, Wan YJY, Yan B (2009) Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochem Pharmacol. 77, 238 – 247.
Shi D, Yang D, Prinssen EP, Brian E. Davies BE, Yan B (2011) Surge in expression of carboxylesterase-1 during the post-natal stage enables a rapid gain of the capacity to activate the anti-influenza prodrug oseltamivir. J Infect Dis. 203, 937-942.
Yang D, Shi D, Yang J, Deng R, Yan B (2011) Scoparone potentially transactivates the bile salt export pump gene and the potentiation is enhanced by cytochrome P450 1A2 but inhibited by protein kinase C inhibitor. Brit J Pharmacol. 164, 1547-1557.
Yang D, Yang J, Shi D, Black C, Deng R, Yan B (2012) Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of cholesteryl ester hydrolase CES1 and bile salt export pump. J Lipid Res. 53, 529-539.
Mao Z, Luan X, Cao G, Liu W, Xiong J, Hu G, Chen R, Ning R, Shang W, Yang J, Yan B. (2012) DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol. 84, 701-711.
Chen YZ, Shi D, Yang D, Yan B (2012) Antioxidant sulforaphane and skin sensitizer trinitrobenzene sulfonate induce carboxylesterase 1 through a novel element responding to nuclear factor-erythroid-2 related factor-2. Biochem Pharmacol. 84, 864-871.
Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B (2013) Carboxylesterase-2 is a highly sensitive target of the anti-obesity agent orlistat with profound clinical implications in the activation of anticancer prodrugs. Biochem Pharmacol. 85, 439–447.
Xiao D, Yang D, Guo L, Lu W, Charpentier M, Yan B (2013) Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anticancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. Brit J Pharmacol. 168, 1989-1999.
Personal website: http://web.uri.edu/pharmacy/research/yan/