- Office: 495A Lab: 490
- Phone: 401.874.9205
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Research interests include (1) the effect of diabetes mellitus on drug disposition and (2) pharmacokinetics and pharmacodynamics of immunosuppressive agents used in organ transplantation.
Doctor of Pharmacy, University of Mashhad, Iran, 1990
Doctor of Philosophy, University of Sydney, Australia, 1997
Post doctoral research associate, University of Sydney, Australia, 1998
Senior Clinical Scientist, University of Cambridge, United Kingdom
Dostalek, M, Sam, W-J, Paryani, KR, Macwan, JS, Gohh, RY, Akhlaghi, F. Diabetes mellitus reduces the clearance of atorvastatin-lactone: the results of a population pharmacokinetic analysis in kidney transplant recipients and in vitro studies using human liver microsomes, Accepted for Publication, Clin Pharmacokinet, March (2012).
Dostalek, M, Akhlaghi, F, Puzanovova, M. Effect of diabetes mellitus on pharmacokinetic and pharmacodynamic properties of drugs. Review Article, Accepted for Publication, Clin. Pharmacokinet., March 2012. Epub, June 5th, (2012).
Macwan JS, Ionita IA, Akhlaghi, F. A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem 402: 1217-27, (2012).
Akhlaghi, F, Dostalek, F, Falck, P, Mendonza, AE, Amundsen, R, Gohh, RY, Åsberg, A. The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus. Ther Drug Monit, 34:38-45, (2012).
Dostalek, M, Court, MH, Yan, B, Akhlaghi, F. Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus. Br J Pharmacol. 163:937-47, (2011).
Macwan, JS, Ionita, IA, Dostalek, M, Akhlaghi, F. Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem. Apr; 400(2): 423-33, (2011); Epub 2011 Feb 26.
Dostalek, M, Court, MH, Hazarika, S, Akhlaghi, F. Diabetes mellitus reduces activity of human UDP-Glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos 39: 448-55, (2011).
Hu, S, Akhlaghi, F, Chitnis, S, Chiu, R, Go, S, Rout, P, Steffes, M, Abbott, JD, Dworkin, L, Bostom, A. Comparison of plasma clearance of iodixanol during versus after angiography. Am J Kidney Dis. 56: 1219-20, (2010).