College of Pharmacy

Avedisian Hall, 7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.eduOffice: 401.874.2761 Fax: 401.874.2181

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Jie Shen, Ph.D.

  • Assistant Professor
  • Office: 495C Lab: 460
  • Phone: 401.874.5594
  • Email: jie_shen@uri.edu
  • Mailing Address: 7 Greenhouse Road, Kingston, RI 02881

Research

Professor Shen’s research is mainly focused on: 1) the development of novel drug delivery systems to improve bioavailability and reduce side effects of a variety of therapeutics, with particular interests in sustained and/or targeted brain and ophthalmic drug delivery, as well as oral drug delivery; 2) formulation development and manufacturing of advanced drug delivery systems (such as liposomes, and nanocarriers); and 3) in vitro and in vivo performance testing, as well as the development of in vitro-in vivo correlation (IVIVC) for complex dosage forms (such as microspheres, implants, and nanoparticles).

Education

Assistant Research Professor, Pharmaceutical Sciences, University of Connecticut, CT, 2016

Postdoctoral Fellow, Pharmaceutical Sciences, University of Connecticut, CT, 2014

Postdoctoral fellow, Pharmaceutics, Fudan University, Shanghai, China, 2010

Ph.D., Pharmaceutics, China Pharmaceutical University, Nanjing, China, 2009

M.S., Pharmaceutics, China Pharmaceutical University, Nanjing, China, 2006

B.S., Pharmaceutical Sciences, China Pharmaceutical University, Nanjing, China, 2001

Publications

Selected Publications

Shen, K. Lee, S. Choi, W. Qu, Y. Wang, D.J. Burgess. A reproducible accelerated in vitro release testing method for PLGA microspheres. International Journal of Pharmaceutics. 2016, 498(1-2): 274-82.

Shen, S. Choi, W. Qu, Y. Wang, D.J. Burgess. In vitro-in vivo correlation of parenteral risperidone polymeric microspheres. Journal of Controlled Release. 2015, 218: 1-12. (Selected as the Editorial Cover Story and Cover Page)

Shen, D.J. Burgess. In vitro-in vivo correlation for complex non-oral drug products: Where do we stand? Journal of Controlled Release. 2015, 2015, 219: 644-51.

Kumar, J. Shen, B. Zolnik, N. Sadrieh, D.J. Burgess. Optimization and dissolution performance of spray-dried naproxen nano-crystals. International Journal of Pharmaceutics. 2015, 486(1-2): 159-66.

Kumar, R. Jog, J. Shen, B. Zolnik, N. Sadrieh, D.J. Burgess. Formulation and performance of danazol nano-crystalline suspensions and spray dried powders. Pharmaceutical Research. 2015, 32(5): 1694-1703.

Kumar, J. Shen, D.J. Burgess. Nano-amorphous spray dried powder to improve oral bioavailability of itraconazole. Journal of Controlled Release. 2014, 192C: 95-102.

Shen*, M. Yu*, Q.G. Meng, J. Li, Y.F. Lv, W.Y. Lu. Fatty acid-based strategy for efficient brain targeted gene delivery. Pharmaceutical Research. 2013, 30(10): 2573-83. (*Equal authorship)

Shen, D.J. Burgess. In vitro dissolution testing strategies for nanoparticulate drug delivery systems: recent developments and challenges. Drug Delivery and Translational Research. 2013, 3(5): 409-15.

Li, Y. Lei, E. Wagner, C. Xie, W.Y. Lu, J.H. Zhu, J. Shen, J. Wang, M. Liu. Potent retro-inverso D-peptide for simultaneous targeting of angiogenic blood vasculature and tumor cells. Bioconjugate Chemistry. 2013, 24(1): 133-43.

Li, J. Shen, X. Wei, C. Xie, W.Y. Lu. Targeted delivery of a novel palmitylated D-peptide for anti-glioblastoma molecular therapy. Journal of Drug Targeting. 2012, 20(3): 264-71.

Shen, D.J. Burgess. Accelerated in vitro release testing methods for extended release parenteral dosage forms. Journal of Pharmacy and Pharmacology. 2012, 64(7): 986-96.

Shen, D.J. Burgess. Accelerated in vitro release testing of implantable PLGA microsphere/PVA hydrogel composite coatings. International Journal of Pharmaceutics. 2012, 422(1-2): 341-48.

Shen, C.Y. Zhan, W.Y. Lu. Poly(ethylene glycol)-block-poly(d,l-lactide acid) micelles anchored with angiopep-2 for brain-targeting delivery. Journal of Drug Targeting. 2011, 19(3): 197-203. (Selected as the Key Article by the Editor-in-Chief)

X.F. Jin, Y. Xu, J. Shen, Q.N. Ping. Chitosan-glutathione conjugate-coated poly (butyl cyanoacrylate) nanoparticles: promising carriers for oral thymopentin delivery. Carbohydrate Polymers. 2011, 86(1): 51-7.

Shen, Y.P. Deng, Q.N. Ping. Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution. International Journal of Pharmaceutics. 2010, 402(1-2): 248-53.

M.J. Sun, Y. Wang, J. Shen, Q.N. Ping. Octreotide-modification enhances the delivery and targeting of doxorubicin-loaded liposomes to somatostatin receptors expressing tumor in vitro and in vivo. Nanotechnology. 2010, 21(47): 475101.

Shen, M.J. Sun, Q.N. Ping. Incorporation of liquid lipid in lipid nanostructured carriers for ocular drug delivery enhancement. Nanotechnology. 2010, 21(2): 025101.

Shen, Y. Wang, Q.N. Ping. Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery. Journal of Controlled Release. 2009, 137(3): 217-23.

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