college of pharmacy

7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.edu – Office: 401.874.2761 Fax: 401.874.2181

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The University of Rhode Island Doctor of Pharmacy program is accredited by the Accreditation Council for Pharmacy Education.

Keykavous Parang, Pharm.D., Ph.D.

keykavous_parang_web
  • Visiting Professor
  • Office: 495E Lab: 410
  • Phone: 401.874.4471
  • Email: kparang@uri.edu
  • Mailing Address: 7 Greenhouse Road, Kingston, RI 02881

Biography

Dr. Parang received his Ph.D. in medicinal chemistry from the University of Alberta in 1997, followed by a postdoctoral study in the fields of carbohydrate chemistry and solid-phase organic synthesis. He pursued additional postdoctoral studies at Rockefeller University and Johns Hopkins University in bioorganic chemistry. Dr. Parang joined the University of Rhode Island in October 2000 and is currently a Professor in Department of Biomedical and Pharmaceutical Sciences.

Dr. Parang’s research can be appropriately described as “the application of synthetic organic chemistry to problems in biology”. Specific areas currently under investigation include (1) using peptides as cell-penetrating molecular transporters in drug delivery; (2) designing protein kinase inhibitors; (3) development of multifunctional anti-HIV, anticancer, and antibacterial agents; (4) synthesis and evaluation of modified nucleosides and nucleic acids; and (5) designing peptide nanomaterials for tissue engineering and nanomedicine.

One recent area currently under investigation is to design peptide nanomaterials for applications in drug delivery and tissue engineering. The objective of this project is to design and evaluate peptide nanomaterials as cell-penetrating nuclear targeting agents, molecular transporters of bioactive cell-impermeable compounds, or self-assembled scaffolds for tissue engineering. This study will document the potential for new hybrid peptide-drug assemblies that may be used for the non-covalent or covalent targeted delivery of bioactive molecules including cell-impermeable compounds with biological significance.

Research

Anticancer, anti-HIV, and antibacterial drug design; peptide nanomaterials for drug delivery and tissue engineering; designing protein kinase inhibitors; synthesis of neuroprotective peptides for application in stroke and CNS Disorders; solid-phase organic synthesis.

Education

Adjunct Faculty, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, 2012-Present

Postdoctoral fellow, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 1999-2000

Postdoctoral fellow, Department of Bioorganic Chemistry, Rockefeller University, 1999

Postdoctoral fellow, Department of Chemistry, University of Alberta, 1997-1999

Ph.D. in Medicinal Chemistry, Faculty of Pharmacy, University of Alberta, 1997

Pharm.D., Faculty of Pharmacy, University of Tehran, 1989

Publications

Agarwal, HK, Chhikara, BS, Hanley, MJ, Ye, G, Doncel, GF, Parang, K. Synthesis and biological evaluation of fatty acyl ester derivatives of (-)-2’,3’-dideoxy-3’-thiacytidine. J. Med. Chem. 55, 4861-4871 (2012).

Agarwal, HK, Chhikara, BS, Quiterio, M, Doncel, GF, Parang, K. Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors. J. Med. Chem. 55, 2672-2687 (2012).

Chhikara, BS, Mandal, D, Parang, K. Synthesis, anticancer activities, and cellular uptake studies of lipophilic derivatives of doxorubicin succinate. J. Med. Chem. 55, 1500-1510 (2012).

Munthayala, M, Chhikara, B, Parang, K, Kumar, A. Ionic liquid-supported synthesis of sulfonamides and carboxamides. ACS Combinatorial Science 14, 60-65 (2012).

Tiwari, R, Parang K. Conformationally constrained peptides as protein tyrosine kinase inhibitors. Current Pharmaceutical Design 18, 2852-2866 (2012).

Mandal, D, Nasrolahi Shirazi, A, Parang, K. Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters. Angew. Chem. Int. Ed. 50, 9633-9637 (2011).

Dash, C, Ahmadibeni, Y, Hanley, MJ, Pandhare, J, Gotte, M, Le Grice, SFJ, Parang, K. Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside _-triphosphates. Bioorg. Med. Chem. Lett. 21, 3519-3522 (2011).

Chhikara, BS, St. Jean, N, Mandal, D, Kumar, A, Parang, K. Fatty-acyl amide derivatives of doxorubicin: Synthesis and in vitro anticancer activities. Eur. J. Med. Chem. 46, 2037-2042 (2011).

Personal website: http://www.uri.edu/pharmacy/faculty/parang/

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