college of pharmacy

7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.edu – Office: 401.874.2761 Fax: 401.874.2181

URI
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The University of Rhode Island Doctor of Pharmacy program is accredited by the Accreditation Council for Pharmacy Education.

Lynnie Trzoss

  • Assistant Professor
  • Office: 395K, Lab: 420
  • Phone: 401.874.4805
  • Email: ltrzoss@mail.uri.edu
  • Mailing Address: Pharmacy Building, 7 Greenhouse Road, Kingston, RI 02881

Research

Our current research interests focus on the investigation of natural products as potential therapeutic agents, as biological probes and as lead structures for medicinal chemistry. Specific areas of research include (1) chemical synthesis of bioactive natural products and small molecules; (2) drug (chemical) probe design and development; (3) target identification and mode of action studies.

Education

Postdoctoral Fellow, Scripps Institution of Oceanography, University of California, San Diego, 2012-2014

Ph.D., Chemistry, University of California, San Diego, 2012

M.S., Chemistry, University of California, Los Angeles, 2007

B.S., Chemistry, University of California, Los Angeles, 2005

Publications

L. Trzoss, T. Fukuda, L. V. Costa-Lotufo, P. Jimenez, J. J. La Clair, W. Fenical. “Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer protective protein dermcidin.” Proc. Natl. Acad. Sci. Accepted.

L. Trzoss, J. Xu, M. H. Lacoske, W. C. Mobley, E. A. Theodorakis. “Illicium sesquiterpenes: Divergent synthetic strategy and neurotrophic activity studies.” Chem. Eur. J. 2013, 19, 6398-6408.

L. Trzoss, J. Xu, M. H. Lacoske, E. A. Theodorakis. “Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation.” Beilstein J. Org. Chem. 2013, 9, 1135-1140.

J. Xu, E. J. E. Caro-Diaz, L. Trzoss, E. A. Theodorakis. “Nature-inspired total synthesis of (-)-Fusarisetin A.” J. Am. Chem. Soc. 2012, 134, 5072-5075.

L. Trzoss, J. Xu, M. H. Lacoske, W. C. Mobley, E. A. Theodorakis. “Enantioselective synthesis of (-)-jiadifenin, a potent neurtrophic modulator.” Org. Lett. 2011, 13, 4554-4557.

J. Xu, L. Trzoss, W. K. Chang, E. A. Theodorakis. “Enantioselective total synthesis of (-)-jiadifenolide.” Angew. Chem. Int. Ed. 2011, 50, 3672-3676.

T. X. Nguyen, M. Dakanali, L. Trzoss, E. A. Theodorakis. “Enantioselective synthesis of the ABC ring motif of norzoanthamine based on asymmetric Robinson annulations reactions.” Org. Lett. 2011, 13, 3308-3311.

D. Fischer, T. X. Nguyen, L. Trzoss, M. Dakanali, E. A. Theodorakis. “Intramolecular cyclization strategies towards the synthesis of Zoanthamine alkaloids.” Tetrahedron Lett. 2011, 38, 4920-4923.

 

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