College of Pharmacy

Avedisian Hall, 7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.eduOffice: 401.874.2761 Fax: 401.874.2181

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Clinical Pharmacokinetics Research

Fatemeh Akhlaghi, Pharm.D., Ph.D.

Located in Lab Module 490 on Level 4 of Avedisian Hall

Abstracts

Dostalek M, Gohh RY, Akhlaghi F. Inosine monophosphate dehydrogenase (IMPDH) gene and protein expression and activity is markedly lower in kidney transplant recipients with diabetes mellitus. Poster presentation at the American Society for Clinical Pharmacology and Therapeutics, 113th Annual Meeting, Abstract Published in Clinical Pharmacology and Therapeutics, Vol 91, Suppl. 1, S87, March 2012 (download poster).

Dostalek M, Sam W-J, Akhlaghi F. Diabetes mellitus reduces the clearance of atorvastatinlactone: the results of a population pharmacokinetic analysis and ex vivo studies using livers from diabetic donors. Poster presentation at the American Society for Clinical Pharmacology and Therapeutics, 113th Annual Meeting, Abstract Published in Clinical Pharmacology and Therapeutics, Vol 91, Suppl. 1, S88, March 2012 (download poster).

Akhlaghi F, Chitnis SD, Ionita I, Christians U, Asberg A. Impact of diabetes mellitus on metabolism of immunosuppressive agents: cyclosporin, tacrolimus and prednisone. Poster Presentation at the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDM&CT), Oct 2011, Stuttgart, Germany. Abstract was published in Ther Drug Monit: 2011; 33 (4) (download abstract)

Akhlaghi F, Dostalek M, Mendonza AE, Chitnis SD, Gohh RY. Reduced levels of biomarkers of immunosuppressive activity in diabetic kidney transplant recipients. Poster/Podium Presentation at the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDM&CT), Oct 2011, Stuttgart, Germany. Abstract was published in Ther Drug Monit: 2011; 33 (4) (download abstract)

Akhlaghi F, Mendonza AE. Non-invasive monitoring of mycophenolic acid in saliva: factors influencing the correlation between saliva and unbound plasma concentration. Poster Presentation at the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDM&CT), Oct 2011, Stuttgart, Germany. Abstract was published in Ther Drug Monit: 2011; 33 (4) (download abstract)

Norris DC, Gohh RY, Akhlaghi F, Morrissey PE. Kalman Filtering for tacrolimus dose titration in the early hospital course after kidney transplant, poster presentation in the American Transplant Congress, May 1-4, 2011, Philadelphia, PA.

Dostalek M, Yan B, Akhlaghi F. Significantly reduced cytochrome P450 3A4 expression and activity in liver from human with diabetes mellitus; Poster presentation at the FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition, November 14 – 18, 2010, New Orleans, LA (download poster)

Macwan JS, Akhlaghi F. Development of a simple method for analysis of atorvastatin (ATV) and metabolites in acid and lactone forms by liquid chromatography-tandem mass spectrometry (LC-MS/MS); Poster presentation at the FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition, November 14 – 18, 2010, New Orleans, LA (download poster).

Chitnis SD, Akhlaghi F. Development and validation of a simple method for quantitative estimation of sirolimus in human whole blood using liquid chromatography-tandem mass spectrometry (LC-MS/MS); Poster presentation at the FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition, November 14 – 18, 2010, New Orleans, LA (download poster).

Chitnis SD, Moll V, Schniedewind B, Christians U, Akhlaghi F. Diabetic kidney transplant recipients exhibit elevated levels of tacrolimus metabolites; Poster presentation at the FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition, November 14 – 18, 2010, New Orleans, LA (download poster) .

Thudium KE, Akhlaghi F. Development and validation of an assay for determination of urinary 6 beta hydroxycortisol to cortisol ratio, a noninvasive marker for CYP3A activity; Poster presentation at the FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition, November 14 – 18, 2010, New Orleans, LA (download poster).

Ionita IA, Gohh RY, Akhlaghi F. Pharmacokinetics of prednisolone and cortisol suppression in diabetic and nondiabetic stable kidney transplant recipients; Poster presentation at the FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition, November 14 – 18, 2010, New Orleans, LA (download poster) .

Akhlaghi F, Gohh RY, Mendonza AE, Flack P, Åsberg A. Reduced cyclosporine metabolism in diabetic stable kidney transplant recipients; Poster presentation at the FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition, November 14 – 18, 2010, New Orleans, LA (download poster).

Hu S, Akhlaghi F, Chitnis SD, Chiu R, Go S, Rout R, Steffes M, Abbott JD, Dworkin L, Bostom A. Accurate prediction of true glomerular filtration rate (GFR) by both immediate post−angiography iodixanol clearance, and pre−angiography estimated GFR. Poster presentation at the American Society of Nephrology (ASN), 43rd Annual Meeting and Scientific Exposition, November 18−21, Denver, CO.

Akhlaghi F, Chitnis SD, Mendonza AE, Ionita IA, Gohh RY. Utilization of B- and T-cell activity markers to evaluate the degree of immunosuppression in diabetic kidney transplant recipients. Invited poster presentation at “Pharmacodynamic and Pharmacogenomic Biomarkers in Solid Organ Transplantation”, September 28, 2010; Food and Drug Administration, White Oak Campus.

Lin S, Henning AK, Akhlaghi F, Reisfield R, Vergara-Silva A, First MR. Interleukin-2 receptor antagonist induction therapy leads to increased tacrolimus levels after kidney transplantation. Presented as Mini Oral Presentation at the XXIII International Congress of The Transplantation Society (TTS 2010) August 15 – 19, 2010, Vancouver, BC, Canada.

Akhlaghi F, Chitnis SD, Mendonza AE, Ionita IA, Gohh RY. Reduced level of biomarkers of immunosuppressive activity in diabetic kidney transplant recipients is related to diabetes type and glucose control, Poster presentation at American Transplant Congress May 1-5, 2010, San Diego, CA.

Pabla D, Akhlaghi F, Zia H. Intestinal permeability enhancement of levothyroxine sodium by medium chain fatty acids studied in MDCK epithelial cell line. Poster presentation at the AAPS Annual meeting and exposition, Nov 2009, Los Angles also abstract published at AAPS Journal (2009).

Akhlaghi F, Monbaliu J, Kadambi V, Yu L. Blood and plasma pharmacokinetics of bortezomib in relation to blood 20s proteasome activity after single and multiple dosing in cynomongolus monkeys. Poster presentation at the American Conference on Pharmacometrics, Oct 4-7, 2009, The Grand Pequot at Foxwoods Resort, Mashantucket, CT.

Akhlaghi F, Monbaliu J, Kadambi V, Prakash S, Lee F, Yu L. Development of an integrated pharmacokinetic and pharmacodynamic model for bortezomib to allow predication of 20s proteasome activity from plasma concentrations. Poster presentation at the American Conference on Pharmacometrics, Oct 4-7, 2009, The Grand Pequot at Foxwoods Resort, Mashantucket, CT.

Paryani K, Gohh R, Akhlaghi F. Elevated atorvastatin lactone concentration in patients with diabetes mellitus; Poster presentation at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 110th Annual Meeting, Washington, DC, March 2009.

Narwal R, Akhlaghi F, Asberg A, Hermann M, Rosenbaum SE. Development of a population pharmacokinetic model for atorvastatin acid and its lactone metabolite; Poster presentation at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 110th Annual Meeting, Washington, DC, March 2009.

 

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