College of Pharmacy

7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.edu – Office: 401.874.2761 Fax: 401.874.2181

URI
Think Big, We Do.
Rhode Island Seal

Chemical Carcinogenesis Research

Bongsup Cho, Ph.D.

Located in Lab Module 450 on Level 4 of the Pharmacy building

Recent Publications

  • N. Jain, S. Meneni, and B. P. Cho.* Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes. Nucleic Acids Res. 37, 1628-1637 (2009).
  • F. Liang and B. P. Cho.* Enthalpy-entropy Contribution to Carcinogen-induced DNA Conformational Heterogeneity. Biochemistry, 49, 259-266 (2010).
  • B. Cho.* The Chemical Biology of DNA Damage. “Structure-function characteristics of aromatic amine-DNA adducts.” Edited by N.E. Geacintov & S. Broyde. Wiley-VCH. (2010).
  • S. Patnaik, and B. P. Cho.* Structures of 2-Acetylaminofluorene Modified DNA Revisited: Insight into Conformational Heterogeneity. Chem. Res. Toxicol., 23, 1650-1652 (2010).
  • F. Liang and B. P. Cho.* Conformational and Thermodynamic Impact of the Bulky Aminofluorene Adduction on a Simulated Translesion DNA Synthesis. Chem. Res. Toxicol., 24, 597-605 (2011).
  • Jain, B. Hilton, S. Patnaik, Y. Zou, M. P. Chiarelli, and B. P. Cho.* Conformational and thermodynamic properties modulate the nucleotide excision repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI sequence. Nucleic Acids Res., 37, 1-13 (2012).
  • V. G. Vaidyanathan and B. P. Cho.* Sequence effects on translesion synthesis of an aminofluorene-DNA adduct: conformational, thermodynamic, and primer extension kinetic studies. Biochemistry, 51, 1983-1995 (2012).
  • V.G. Vaidyanathan, L. Xu, B. P. Cho.* Binary and ternary binding affinities between exonuclease-deficient Klenow Fragment (Kf-exo(-)) and various arylamine DNA lesions characterized by surface plasmon resonance. Chem. Res. Toxicol. 25, 1568-70 (2012).
  • B.P. Cho* and N.J. Owens.* The University of Rhode Island College of Pharmacy. Editorial. Med. Health R.I., 95, 272 (2012).
  • V. Jain, B. Hilton, B. Lin, S. Patnaik, F. Liang, E. Darian, Y. Zou, A D. MacKerell Jr., and B.P. Cho.* Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor, Nucleic Acids Res., 41, 869-880 (2012).
  • V. G. Vaidyanathan, Lifang Xu, and Bongsup P. Cho.* Binding kinetics of DNA-protein interaction using surface plasmon resonance. Nature Protocol Exchange. Online. May 22, 2013. doi:10.1038/protex.2013.054 http://www.nature.com/protocolexchange/protocols/2721. (2013)
  • A. Sandineni, B. Lin, A. D. Mackerell, B. P. Cho.* Structure and thermodynamic insights on acetylaminofluorene-modified deletion DNA duplexes as models for frameshift mutagenesis. Chem. Res. Toxicol. 26, 937-951 (2013).
  • V. G. Vaidyanathan, F. Liang, W. A. Beard, D. D. Shock, S. H. Wilson and B. P. Cho.* Insights into the Conformation of Aminofluorene-dG Adduct in a DNA Polymerase Active Site. J. Biol. Chem. 23573-85 (2013).
  • D. Jean-Gilles, L. Li, V.G. Vaidyanathan, R. K. King, B. P. Cho, D. R. Worthen, C. O. Chichester III, and N. P. Seeram. Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo. Chem-Biol Interact. 205, 90-99 (2013).
  • V. Jain, B. Hilton, B. Lin, A. Jain, A. D. MacKerell, Y. Zou, and B. P. Cho.* Structural and thermodynamic insight into E. coli UvrABC mediated incision of cluster di-acetylaminofluorene adducts on the NarI sequence. Chem. Res. Toxicol. 1251-1261 (2013).
  • Jain, V. G. Vaidyanathan, S. Patnaik, S. Gopal, and B. P. Cho.* Conformational Insights into the Lesion and Sequence Effects for Arylamine-Induced Translesion DNA Synthesis: 19F NMR, Surface Plasmon Resonance, and Primer Kinetic Studies. Biochemistry 53, 4059-71 (2014).
  • Xu, V. G. Vaidyanathan, B. P. Cho.* Real-time surface plasmon resonance study of biomolecular interactions between polymerase and bulky mutagenic DNA lesions. Chem. Res. Toxicol., 27, 1796-807 (2014).
  • B. Hilton, S. Gopal, L. Xu, S. Mazumder, P. R. Musich, and B. P. Cho*, Y. Zou.*  Dissociation dynamics of XPC-HR23B from damaged DNA is a determining factor of NER efficiency.   PLOS, http://dx.doi.org/10.1371/journal.pone.0157784. Published: June 21, 2016
  • L. Xu and B. P. Cho.* Conformational Insight on the Mechanism of Acetylaminofluorene-dG induced Frameshifts Mutation in the NarI Mutational Hotspot. Chem. Res. Toxicol. 29, 213-226 (2016).

Complete List of Peer-Reviewed Publications

  1. H. Lyu, B. Youn, and B. Cho. Synthesis of heterocyclic fused-ring mesoisonic compounds, J. Nat. Sci. Res. Institute, 3, 85-92 (1979).
  2. S. K. Arora, B. Cho, R. J. Anderson, and D. L. Venton. A Convenient Single Step Preparation of Dopamine-4-O-sulfate, Synthesis, 884 (1984).
  3. S. K. Arora, B. P. Cho, V. K. Chada, A. J. Bauer, C. T. Lim, G. C. LeBreton, and D. L. Venton. An Interesting By-product Obtained from Reaction of 4-Butoxy-2-butenoate with the Alkoxide Anion of Methyl Glycolate, J. Heterocyclic Chem., 23, 963-964 (1986).
  4. B. P. Cho, V. K. Chada, G. C. LeBreton, and D. L. Venton. Synthesis of 9-Hydroxy-14-azaprostanoic Acids, J. Org. Chem., 51, 4279-4284 (1986).
  5. B. P. Cho and R. G. Harvey. Synthesis of Polycyclic Aromatic Fluoranthenes, Tetrahedron Letters, 28, 861-864, 2906 (1987).
  6. B. P. Cho and R. G. Harvey. Polycyclic Fluoranthene Hydrocarbons. 2. A New General Synthesis, J. Org. Chem., 52, 5668-5678 (1987).
  7. B. P. Cho and R. G. Harvey. Complete 1H and 13C NMR Assignment of Polycyclic Aromatic Fluoranthene Hydrocarbons by Long-range Optimized Homo- and Hetero-nuclear Correlation Spectroscopy, J. Org. Chem., 52, 5679-5684 (1987).
  8. M. Minabe, B. P. Cho, and R. G. Harvey. Electrophilic Substitution of Polycyclic Fluoranthene Hydrocarbons, J. Am. Chem. Soc., 111, 3809-3812 (1989).
  9. S. J. Culp, B. P. Cho, F. E. Evans, and F. F. Kadlubar. Structural and Conformational Analyses of 8-Hydroxy-2′-deoxyguanosine, Chem. Res. Toxicol., 2, 416-422 (1989).
  10. B. P. Cho, S. J. Culp, F. E. Evans, and F. F. Kadlubar. 15N Nuclear Magnetic Resonance Studies on the Tautomerism of 8-Hydroxy-2′-deoxyguanosine, 8-Hydroxyguanosine and Other C8-substituted Guanine Nucleosides, Chem. Res. Toxicol., 3, 445-452 (1990).
  11. E. H. Weyand, S. Patel, E. J. LaVoie, B. P. Cho, and R. G. Harvey. Relative Tumor-initiating Activity of Benzo[a]fluoranthene, Benzo[b]fluoranthene, Naphtho[1,2-b]fluoranthene, and Naphtho[2,1-a]fluoranthene on Mouse Skin, Cancer Letters, 52, 229-233 (1990).
  12. B. P. Cho and F. E. Evans. Complete 1H and 13C Chemical Shift Assignments of 1-Nitropyrene, Spectroscopy Letters, 24, 1-7 (1991).
  13. B. P. Cho and F. E. Evans. Structure of Oxidatively Damaged Nucleic Acid Adducts. 3. Tautomerism, Ionization, and Protonation of 8-Hydroxyadenosine Studied by 15N NMR Spectroscopy, Nucleic Acids Research, 19, 1041-1047 (1991).
  14. B. P. Cho and F. E. Evans. Correlation between NMR Parameters of Nucleosides and Its Implication about the Glycosyl Bond, Biochem. Biophys. Res. Commun., 180, 273-278 (1991).
  15. S. A. Tucker, W. E. Acree, Jr., B. P. Cho, R. G. Harvey, J. C. Fetzer. Spectroscopic Properties of Polycyclic Aromatic Hydrocarbons: Effect of Solvent Polarity on the Fluorescence Emission Behaviour of Selected Fluoranthene, Fluorenochrysene, Indenochrysene, and Indenopyrene Derivatives, Applied Spectroscopy, 45, 1699-1705 (1991).
  16. B. P. Cho, F. A. Beland, and M. M. Marques. NMR Structural Studies of a 15-mer DNA Sequence from ras Protooncogene, Modified at the First Base of Codon 61 with the Carcinogen 4-Aminobiphenyl, Biochemistry, 31, 9587-9602 (1992).
  17. B. P. Cho, F. A. Beland, and M. M. Marques. One-dimensional Multiple Quantum Filtration 1H NMR Spectra of a 15-Mer DNA Duplex Modified by the Carcinogen 4-Aminobiphenyl, Mag. Reson. Chem., 31, 1008-1010 (1993).
  18. B. P. Cho, M. Kim, and R. G. Harvey. Synthesis and Conformational Analysis of Nitropolycyclic Fluoranthenes, J. Org. Chem., 58, 5788-5796 (1993).
  19. B. P. Cho. Structure of Oxidatively Damaged Nucleic Acid Adducts: The pH Dependence of the 13C NMR Spectra of 8-Oxoguanosine and 8-Oxoadenosine, Mag. Reson. Chem., 31, 1048-1053 (1993).
  20. B. P. Cho, F. A. Beland, and M. M. Marques. NMR Structural Studies of a 15-mer DNA Duplex from ras Protooncogene Modified with the Carcinogen 2-Aminofluorene: Conformational Heterogeneity, Biochemistry, 33, 1373-1384 (1994).
  21. B. P. Cho and M. A. McGregor. Tautomerism, Protonation and Ionization of Formycin in Aqueous Solution by the pH Dependence of 13C Chemical Shifts and 13C-1H Coupling Constants, Nucleosides & Nucleotides, 13, 481-490 (1994).
  22. B. P. Cho. A Novel and Practical Synthesis of Polycyclic Fluoranthenes, Tetrahedron Letters, 36, 2403-2406 (1995).
  23. B. P. Cho. Recent Progress in the Syntheses of Nitropolyarenes. A Review, Org. Prep. Proc. Int., 27, 243-272 (1995).
  24. E. B. Hansen Jr., B. P. Cho, W. A. Korfmacher, and C. E. Cerniglia. Fungal Transformations of Antihistamines: Metabolism of Bromopheniramine, Chloropheniramine, and Pheniramine to N-Oxide and N-Demethylated Derivatives by the Fungus Cunninghamella Elegans, Xenobiotica, 25, 1081-1092 (1995).
  25. B. P. Cho and L. Zhou. Attempted Synthesis of Fjord-region Containing Polycyclic Fluoranthenes Reveals A Steric-Driven Double Wagner-Meerwein Rearrangement, Tetrahedron Letters, 37, 1535-1538 (1996).
  26. B. P. Cho and L. Zhou. A New Synthesis of Polycyclic Fluoranthenes of Cyclodehydration of a Keto-adduct Formed by Michael Reaction, Polycyclic Aromat. Compds., 11, 261-266 (1996).
  27. Pandey, J. R. Powell, W. E. Acree, Jr., B. P. Cho, and J. C. Fetzer, Spectroscopic Properties of Polycyclic Aromatic Compounds. Part 6. The Nitromethane Selective Quenching Rule Revisited in Aqueous Micellar Zwitterionic Surfactant Solvent Media, Talanta, 44, 413-421 (1997).
  28. Pandey, J. R. Powell, W. E. Acree, Jr., B. P. Cho, J. Kum, C. Y. Yang, and R. G., Harvey. Spectroscopic Properties of Polycyclic Aromatic Compounds. Part 5. The Nitromethane Selective Quenching Rule Revisited in Aqueous Micellar Solvent Media, Polycyclic Aromat. Compds., 12, 1-19 (1997).
  29. L. Zhou, M. Rajabzadeh, D. D. Traficante, and B. P. Cho. Conformational Heterogeneity of Arylamine-Modified DNA: 19F NMR Evidence, J. Am. Chem. Soc., 119, 5384-5389 (1997).
  30. L. Zhou and B. P. Cho. Comparative Conformational Analyses of N-(Deoxyguanosin-8- yl)aminopyrene Adducts Derived from the Isomeric Carcinogens 1, 2, and 4-Nitropyrene, Chem. Res. Toxicol., 11, 35-43 (1998).
  31. Y.-H. Chae, B.-Y. Ji, J.-M. Lin, P. P. Fu, B. P. Cho, and K. El-Bayoumy. Nitroreduction of 4-Nitropyrene is Primarily Responsible for DNA Adduct Formation in the Mammary Gland of Female CD Rats, Chem. Res. Toxicol., 12, 180-186 (1999).
  32. B. P. Cho and L. Zhou. Probing the Conformational Heterogeneity of the Acetylaminofluorene-modified 2’-Deoxyguanosine and DNA by 19F NMR Spectroscopy, Biochemistry, 38, 7572-7583 (1999).
  33. F. Liu and B. P. Cho. Dimethyldioxirane Epoxidation of Polycyclic Fluoranthene Hydrocarbons, Biorg. & Biomed. Chem. Letters, 9, 2181-2184 (1999).
  34. H.-F. Chang and B. P. Cho. Synthesis of anti- and syn-Diol Epoxides of trans-3,4-Dihydroxy-3,4-dihydrobenzo[ghi]fluoranthene: Model planar Diol Epoxides, J. Org. Chem., 64, 9051-9056 (1999).
  35. B. P. Cho, L. R. Blankenship, J. D. Moody, D. R. Doerge, F. A. Beland S. J. Culp, Synthesis and Characterization of 4´-Amino and 4´-Nitro Derivatives of 4-N,N-Dimethylaminotriphenylmethane as Precursors for a Proximate Malachite Green Metabolite, Tetrahedron., 58, 7379-7388 (2000).
  36. D. Huffer, H.-F. Chang, B. P. Cho, M. P. Chiarelli. Differentiation of Diastereomeric Benzo[ghi]fluoranthene Tetraols by Matrix-Assisted Lase Desorption Ionization Time-of-Flight Mass Spectromerty (MALDI) and Post-source Decay (PSD), J. Am. Soc. Mass Spectrom., 12, 376-380 (2001).
  37. H.-F. Chang, D. M. Huffer, M. P. Chiarelli, and B. P. Cho. Characterization of DNA Adducts and Tetraols Derived from anti-Benzo[ghi]fluoranthane-3,4-Dihydrodiol-5,5a-Epoxide, Chem. Res. Toxicol., 15, 187-197 (2002).
  38. H.-F. Chang, D. M. Huffer, M. P. Chiarelli, L. R. Blankenship, S. J. Culp, and B. P. Cho. Characterization of DNA Adducts Derived from syn-Benzo[ghi]fluoranthene-3,4-Dihydrodiol-5,5a Epoxide and Comparative DNA Binding Studies with Structurally-Related anti-Diolepoxides of Benzo[ghi]fluoranthene and Benzo[c]phenanthrene, Chem. Res. Toxicol., 15, 198-208 (2002).
  39. B. P. Cho, T.Yang, L. R. Blankenship, J. D. Moody, M. Churchwell, F. A. Beland, and S. J. Culp. Synthesis and Characterization of N-Demethylated Metabolites of Malachite Green and Leucomalachite Green, Chem. Res. Toxicol., 16, 285-294 (2003).
  40. T. Yang and B. P. Cho. Preparation of Diarylamines by a Novel Aryllithium-mediated Carbon-Nitrogen Bond-forming Reaction with Nitroarenes, Tetrahedron Letters, 44, 7549-7552 (2003).
  41. M. P. Chiarelli, H-F. Chang, K. W. Olson, D. Barbacci and B. P. Cho. Structural Differentiation of Diastereomeric Benzo[ghi]fluoranthene Adducts of Deoxyadenosine by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and Post-Source Decay, Chem. Res. Toxicol., 16, 1236-1241 (2003).
  42. B. P. Cho. Dynamic Conformational Heterogeneities of Carcinogen-DNA Adducts and Their Mutagenic Relevance, J. of Environ. Sci. and Health, Part C-Environmental Carcinogenesis & Ecotoxicology Reviews, 22, 57-90 (2004).
  43. A. G. Del Signore, M. A. McGregor and B. P. Cho. 1H NMR Analysis of GHB and GBL: Further Findings on the Interconversion and a Preliminary Report on the Analysis of GHB in Serum and Urine, J. Forensic Sci.,50, 81-86 (2005)
  44. L. Linge, H.-F. Chang, K. W. Olsen, B. P. Cho, and M. P. Chiarelli. Product Ion Studies of Diastereomeric Benzo[ghi]fluoranthene Adducts of Deoxyadenosine by Electrospray Ionization and Quadrupole Ion Trap Mass Spectrometry, Acta Chemica Acta, 557, 191-197 (2006).
  45. T. Yang, Y. Huang, and B. P. Cho. Synthesis and Characterization of Enantiomeric anti-2-Fluorobenzo[a]pyrene- 7,8-dihydrodiol-9,10-epoxides and their 2’-Deoxyguanosine and Oligodeoxynucleotide Adducts. Chem. Res. Toxicol., 19, 242-254 (2006).
  46. S. R. Meneni, R. D’Mello, G. Norigian, G. Baker, L. Gao, M. P. Chiarelli, and B. P. Cho. Sequence effects of aminofluorene- modified DNA duplexes: UV thermodynamic and circular dichroism properties. Nucleic Acids Res., 34, 755-763 (2006). [PDF (Correction)]
  47. F. Liang, S. Meneni and B. P. Cho. Induced Circular Dichroism Characteristics as Conformational Probes for Carcinogenic Aminofluorene-DNA Adducts, Chem. Res. Toxicol., 19, 1040-1043 (2006).
  48. S. Meneni, S. M. Shell, Y. Zou, and B. P Cho. Conformation-specific Recognition of Carcinogen-DNA Adduct in E. coli. Nucleotide Excision Repair. Chem.. Res. Toxicol., 20, 6-10 (2007).[PDF]
  49. S. Meneni, F. Liang and B. P. Cho. Examination of the long-range effects of aminofluorene-induced conformational heterogeneity and its relevance to the mechanisms of translesion DNA synthesis. J. Mol. Biol., 366, 1387-1400 (2007).
  50. S. Meneni, S. M. Shell, L. Gao, P. Jurecka, W. Lee, J. Sponer, Y. Zou, M. P. Chiarelli, and B. P. Cho. Spectroscopic and Theoretical Insights into Sequence Effects of Aminofluorene-induced Conformational Heterogeneity and Nucleotide Excision Repair. Biochemistry, 40, 11263-11278 (2007).
  51. F. Liang and B. P. Cho. Probing the Thermodynamics of Aminofluorene-Induced Translesion DNA Synthesis by Differential Scanning Calorimetry. J. Am. Chem. Soc. (Communication), 129, 12108-12109 (2007).
  52. Nidhi Jain, Yuyuan Li, Li Zhang, Srinivasa Meneni, and Bongsup Cho, Probing the Sequence Effects on NarI-Induced -2 Frameshift Mutagenesis by Dynamic 19F NMR, UV, and CD Spectroscopy, Biochemistry, 46, 13310-13321 (2007).
  53. N. Jain, Y. K. Reshetnyak, L. Gao, M. P. Chiarelli, and B. P. Cho. Fluorescence probing of aminofluorene-induced conformational heterogeneity in DNA duplexes, Chem. Res. Toxicol. 21, 445-452 (2008).
  54. L. Gao, L. Zhang, B. P. Cho, and M. P. Chiarelli. Sequence Verification of Oligonucleotides Containing Multiple Arylamine Modifications by Enzymatic Digestion and Liquid Chromatography Mass Spectrometry (LC/MS). J. Am. Mass. Spectrom., 19, 1147-1155 (2008).
  55. F. Liang, N. Jain, T. Hutchens, D. D. Shock, W. A. Beard, S. H. Wilson, M. P. Chiarelli, and B. P. Cho& alhpa;,β-Methylene-2’-deoxynucleoside 5’-triphosphates as non-cleavable substrates for DNA polymerases: Isolation, characterization, and stability studies of novel 2’-deoxycyclonucleosides, 3,5’-anhydro-dG and 2,5’-anhydro-dT. J. Med. Chem., 51, 6460 (2008)
  56. N. Jain, S. Meneni, and B. P. Cho.* Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes. Nucleic Acids Res. 37, 1628-1637 (2009).
  57. F. Liang and B. P. Cho.* Enthalpy-entropy Contribution to Carcinogen-induced DNA Conformational Heterogeneity. Biochemistry, 49, 259-266 (2010).
  58. B. Cho.* The Chemical Biology of DNA Damage. “Structure-function characteristics of aromatic amine-DNA adducts.” Edited by N.E. Geacintov & S. Broyde. Wiley-VCH. (2010).
  59. S. Patnaik, and B. P. Cho.* Structures of 2-Acetylaminofluorene Modified DNA Revisited: Insight into Conformational Heterogeneity. Chem. Res. Toxicol., 23, 1650-1652 (2010).
  60. F. Liang and B. P. Cho.* Conformational and Thermodynamic Impact of the Bulky Aminofluorene Adduction on a Simulated Translesion DNA Synthesis. Chem. Res. Toxicol., 24, 597-605 (2011).
  61. Jain, B. Hilton, S. Patnaik, Y. Zou, M. P. Chiarelli, and B. P. Cho.* Conformational and thermodynamic properties modulate the nucleotide excision repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI sequence. Nucleic Acids Res., 37, 1-13 (2012).
  62. V. G. Vaidyanathan and B. P. Cho.* Sequence effects on translesion synthesis of an aminofluorene-DNA adduct: conformational, thermodynamic, and primer extension kinetic studies. Biochemistry, 51, 1983-1995 (2012).
  63. V.G. Vaidyanathan, L. Xu, B. P. Cho.* Binary and ternary binding affinities between exonuclease-deficient Klenow Fragment (Kf-exo(-)) and various arylamine DNA lesions characterized by surface plasmon resonance. Chem. Res. Toxicol. 25, 1568-70 (2012).
  64. B.P. Cho* and N.J. Owens.* The University of Rhode Island College of Pharmacy. Editorial. Med. Health R.I., 95, 272 (2012).
  65. V. Jain, B. Hilton, B. Lin, S. Patnaik, F. Liang, E. Darian, Y. Zou, A D. MacKerell Jr., and B.P. Cho.* Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor, Nucleic Acids Res., 41, 869-880 (2012).
  66. V. G. Vaidyanathan, Lifang Xu, and Bongsup P. Cho.* Binding kinetics of DNA-protein interaction using surface plasmon resonance. Nature Protocol Exchange. Online. May 22, 2013. doi:10.1038/protex.2013.054 http://www.nature.com/protocolexchange/protocols/2721. (2013)
  67. A. Sandineni, B. Lin, A. D. Mackerell, B. P. Cho.* Structure and thermodynamic insights on acetylaminofluorene-modified deletion DNA duplexes as models for frameshift mutagenesis. Chem. Res. Toxicol. 26, 937-951 (2013).
  68. V. G. Vaidyanathan, F. Liang, W. A. Beard, D. D. Shock, S. H. Wilson and B. P. Cho.* Insights into the Conformation of Aminofluorene-dG Adduct in a DNA Polymerase Active Site. J. Biol. Chem. 23573-85 (2013).
  69. D. Jean-Gilles, L. Li, V.G. Vaidyanathan, R. K. King, B. P. Cho, D. R. Worthen, C. O. Chichester III, and N. P. Seeram. Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo. Chem-Biol Interact. 205, 90-99 (2013).
  70. V. Jain, B. Hilton, B. Lin, A. Jain, A. D. MacKerell, Y. Zou, and B. P. Cho.* Structural and thermodynamic insight into E. coli UvrABC mediated incision of cluster di-acetylaminofluorene adducts on the NarI sequence.. Chem. Res. Toxicol. 1251-1261 (2013).
  71. V. Jain, V. G. Vaidyanathan, S. Patnaik, S. Gopal, and B. P. Cho.* Conformational Insights into the Lesion and Sequence Effects for Arylamine-Induced Translesion DNA Synthesis: 19F NMR, Surface Plasmon Resonance, and Primer Kinetic Studies. Biochemistry 53, 4059-71 (2014).
  72. L. Xu, V. G. Vaidyanathan, B. P. Cho.* Real-time surface plasmon resonance study of biomolecular interactions between polymerase and bulky mutagenic DNA lesions. Chem. Res. Toxicol. 27, 1796-807 (2014).
  73. H. Ma, L. Wang, D. B. Niesen, A. Cai, B. P. Cho, W. Tan,* Q. Gu, J. Xu* and N. P. Seeram.* Structure activity related, mechanistic, and modeling studies of gallotannins containing a glucitol-core and a-glucosidase.  RSC Advances 5, 107904-107915 (2015).
  74. B. Hilton, S. Gopal, L. Xu, S. Mazumder, P. R. Musich, and B. P. Cho*, Y. Zou.*  Dissociation dynamics of XPC-HR23B from damaged DNA is a determining factor of NER efficiency.   PLOShttp://dx.doi.org/10.1371/journal.pone.0157784. Published: June 21, 2016
  75. L. Xu and B. P. Cho.* Conformational Insight on the Mechanism of Acetylaminofluorene-dG induced Frameshifts Mutation in the NarI Mutational Hotspot. Chem. Res. Toxicol. 29, 213-226 (2016).

Copyright © 2016 University of Rhode Island.

The University of Rhode Island
Think Big, We Do.
A-ZDirectoryContact UsJump to top