Located in Lab Module 350 on Level 3 of Avedisian Hall
My research program is primarily focused on investigating bile acid and cholesterol homeostasis under physiological and pathological conditions. Disruption of bile acids and cholesterol homeostasis by genetic or environmental factors has been associated with various diseases, including intrahepatic cholestasis, hypercholesterolemia, gallstone disease, hepatic cellular carcinoma (HCC) and metabolic diseases such as diabetes. Bile salt export pump (BSEP) is responsible for biliary excretion of bile acids and plays a critical role in maintaining intrahepatic as well as systemic bile acid levels. The long-term goal of my research program is to understand the transcriptional regulation of BSEP by endobiotics, such as bile acids and estrogens, and xenobiotics, such as drugs and toxicants, and its implications in various bile acid-related diseases.