Department of Physics

East Hall, 2 Lippitt Road, Kingston, RI 02881

contact@phys.uri.edu401.874.2633/34 (ph); 401.874.2380 (f)

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  • Professor and Chair
  • Room 109
  • Phone: 401.874.2054
  • Fax: 401.874.2380
  • Email: andreev@uri.edu
  • Mailing Address: 2 Lippitt Rd.,East Hall, Room #223
    Physics Department, URI
    Kingston, RI 02881

Biography

2013-present:      Professor, Physics Department, University of Rhode Island.

2013-present:      Professor Adjunct, Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert Brown Medical School.

2012-present:      Chair, Physics Department, University of Rhode Island.

2009-2013:            Associate Professor, Physics Department, University of Rhode Island.

2007–2009:          Assistant Professor, Physics Department, University of Rhode Island.

2005–2007:          Research Assistant Professor, Physics Department, University of Rhode Island.

2004–2005:          Visiting Scientist, Department of Molecular Biophysics and Biochemistry, Yale

2003–2004:          Senior Research Scientist, Sopherion Theraputics, Inc

1996–2003:           Research Assistant Professor, Department of Molecular Biology and Immunology, North Texas University

1996:                    Associate Biophysicist, Baylor University Medical Center at Dallas

1995–1996:           Faculty Research Associate, University of Texas at Austin

1993–1995:            Associate Biophysicist, Baylor University Medical Center at Dallas

Research

Biological physics: membrane biophysics, molecular motors, fluorescent microscopy, fluorescence polarization imaging, spectral analysis from cells, electric cell substrate impedance sensing on cells

Medical physics and nanotechnology: pH-imaging, novel approaches in drug delivery and tumor targeting, clinical fluorescent imaging and instumentation, delivery of nanopores to cancer cells, hyperthermia.

Education

1990 – 1993:     Postdoctoral   Research    Associate;   Baylor University Medical Center, Dallas.

1990:                   Ph.D. in Physics and Mathematics (Biological Physics), Moscow Institute of Physics and Technology, Moscow, Russia

1979:                   M.S. in Physics, Moscow Institute of Physics and Technology, Moscow, Russia

Publications

SELECTED PUBLICATIONS

  • Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ. (2015) The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A. 112(31):9710-5.
  • Arachchige MC, Reshetnyak YK, Andreev OA. (2015) Advanced targeted nanomedicine. J Biotechnol. 202:88-97.
  • P.Antosh, D. D. Wijesinghe, S. Shrestha, R. Lanou, Y. H. Huang, T. Hasselbacher, D. Fox, N. Nerettia, S. Sun, N. Katenka, L. N. Cooper, O. A. Andreev, Y. K. Reshetnyak, (2015) Enhancement of radiation effect on cancer cells by gold-pHLIP, Proc Natl Acad Sci U S A., 112 (17), 5372-5376
  • Ganga P Sharma, Yana K Reshetnyak, Oleg A Andreev, Michael Karbach and Gerhard Müller; “Coil-helix transition of polypeptide at water-lipid interface” J. Stat. Mech. (2015).
  • Karabadzhak, A.G., An, M., Yao, L., Langenbacher, R., Moshnikova, A., Adochite, R.C., Andreev, O.A., Reshetnyak, Y.K., Engelman, D.M. (2014). pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo. ACS Chem Biol. 9(11), 2545-2553.
  • Adochite R.C., Moshnikova A., Carlin S.D., Guerrieri R.A., Andreev O.A., Lewis J.S., (2014) Reshetnyak, Y.K. Targeting Breast Tumors with pH (Low) Insertion Peptides. Mol Pharm. 11, 2896-905.
  • Viola-Villegas, N. T., S. D. Carlin, E. Ackerstaff, K. K. Sevak, V. Divilov, I. Serganova, N. Kruchevsky, M. Anderson, R. G. Blasberg, O. A. Andreev, D. M. Engelman, J. A. Koutcher, Y. K. Reshetnyak, and J. S. Lewis. (2014) Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A 111, 7254-7259.
  • O.A. Andreev, D. M. Engelman, Y.K. Reshetnyak, (2014) Targeting diseased tissues by pHLIP insertion at low cell surface pH, Frontiers in Physiology and Membrane Biophysics, 5, article 97, 1-7.
  • Antosh, D. D. Wijesinghe, S. Shrestha, R. Lanou, Y. H. Huang, T. Hasselbacher, D. Fox, N. Nerettia, S. Sun, N. Katenka, L. N. Cooper, O. A. Andreev, Y. K. Reshetnyak, (2015) Enhancement of radiation effect on cancer cells by gold-pHLIP, Proc Natl Acad Sci U S A., 112 (17), 5372-5376
  • Cruz-Monserrate, C. L. Roland, D. Deng, T. Arumugam, A. Moshnikova, O. A. Andreev, Y. K. Reshetnyak, C. D. Logsdon (2014) Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment”, Scientific Reports, 4, 4410, 1-8.
  • Wijesinghe, M. C. Mallawa Arachchige, A. Lu, Y. K. Reshetnyak, O. A. Andreev (2013) Transfer of nano-pores into membrane of cancer cells induces intracellular acidification and apoptosis, Scientific Reports, Vol. 3: 3560, 1-7.
  • Weerakkody, A. Moshnikova, M. S. Thakur, V. Moshnikova, J. Danniels, D. M. Engelman, O. A. Andreev, Y. K. Reshetnyak A Family of pH (Low) Insertion Peptides for Tumor Targeting (2013) Proced. Natl. Acad. Sci U.S.A., 110, 15, 5834-5839.
  • Yao L, J. Daniels, A. Moshnikova, S. Kuznetsov, A Ahmed, D.M. Engelman, Y.K. Reshetnyak, O.A. Andreev (2013) The pHLIP peptide targets nanogold particles to tumors, Proced. Natl. Acad. Sci U.S.A., 110(2), 465-470
  • E.A. Sosunov, E. P. Anyukhovsky, A. A. Sosunov, A. Moshnikova, D. Wijesinghe, D. M. Engelman, Y. K. Reshetnyak, O. A. Andreev, pHLIP targets ischemic myocardim (2013) Proced. Natl. Acad. Sci U.S.A., 110 (1), 82-86.
  • Y.K. Reshetnyak, C. N. Prudence, J. Segala, V.S. Markin, O.A. Andreev (2012) Parking problem and negative cooperativity of binding of myosin subfragment 1 to F-actin, BBRC, 425, 746-749.
  • K. Reshetnyak, L. Yao, S. Zheng, S. Kuznetsov, D. M. Engelman, O. A. Andreev (2011), Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP, Molecular Imaging and Biology, 27(7), 341–352.
  • L Yao,  J. Segala, A. J.   Bucci, G. O. Andreev,  Y. K. Reshetnyak, and O. A. Andreev (2010) Fluorescence  Anisotropy  Imaging Microscopy,  Microscopy:  Science,  Technology, Applications and Education. Volume 4 (book chapter).
  • Andreev O.A., A. G. Karabadzhak,  D. Weerakkody,  G. O. Andreev, D. M. Engelman, Y. K. Reshetnyak (2010) The pHLIP peptide inserts across a lipid bilayer as a helix, and exits by a different path, Proced. Natl. Acad. Sci U.S.A., 107 (9), 4081-4086.
  • Yao L., G.O. Andreev, Y.K. Reshetnyak, O.A. Andreev (2009) Fabrication of semiconductor nanowires by conjugation of quantum dots to actin filaments, Anal Bional  Chem. 395, 5, 1563-1566.
  • Andreev O.A., Engelman  D. M., and Y.K.  Reshetnyak,  (2009) Targeting  acidic diseased tissue. New technology based on use of the   pH (Low) Insertion Peptide (pHLIP) Chemistry Today, 27, 10-13.
  •  Andreev,  O.A., &  Y.K.  Reshetnyak.  (2007) Mechanism of  formation of  Actomyosin interface. J. Mol. Biol. 365 (3), 551-554.
  • Andreev, O.A., L.D. Saraswat, S. Lowey & J. Borejdo. (1999) Interaction of the N‑terminus  of the chicken skeletal essential light chain 1 with F-actin. Biochemistry 38, 2480-2485.
  • A. Andreev, A. D. Dupuy, M. Segala, S. Sandugu, D. A. Serra, C. O. Chichester, D. M. Engelman, Y. K. Reshetnyak (2007) Mechanism and Uses of a Peptide that Targets Tumors and other Acidic Tissue In vivo, Proced. Natl. Acad. Sci U.S.A. 104 (19) 7893-7898.
  • Andreev, O.A., & Borejdo, J. (1997) The interaction of heavy and  light chains of cardiac myosin subfragment‑1 with F‑actin. Circulation Research, 81, 688‑693.
  • Andreev O.A., & Borejdo J. (1995) The interaction of myosin subfragment 1 and alkali light chain 1 with F‑actin. Biochemistry 34, 14829‑14833.

Awards and Honors:

2015: URI Excellence Award
2014: URI outstanding inventor
2013: URI outstanding inventor
2012: Maitland P. Simmons Memorial Research Award
2012: URI outstanding inventor
2011: Maitland P. Simmons Memorial Research Award
2010: URI outstanding inventor
2006: URI outstanding inventor

Personal website: http://www.biophys.phys.uri.edu/

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