Department of Physics

East Hall, 2 Lippitt Road, Kingston, RI 02881

physics@etal.uri.edu401-874-2104

URI
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Oleg Andreev

  • Professor
  • Pastore, Room 304B
  • Phone: 401.874.4482
  • Fax: 401.874.2380
  • Email: andreev@uri.edu
  • Office Location: 2 Lippitt Rd.,East Hall, Room #223
    Physics Department, URI
    Kingston, RI 02881

Biography

2013-present:      Professor, Physics Department, University of Rhode Island.

2013-present:      Professor Adjunct, Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert Brown Medical School.

2012-2019:          Chair, Physics Department, University of Rhode Island.

2009-2013:          Associate Professor, Physics Department, University of Rhode Island.

2007–2009:          Assistant Professor, Physics Department, University of Rhode Island.

2005–2007:          Research Assistant Professor, Physics Department, University of Rhode Island.

2004–2005:          Visiting Scientist, Department of Molecular Biophysics and Biochemistry, Yale

2003–2004:          Senior Research Scientist, Sopherion Theraputics, Inc

1996–2003:           Research Assistant Professor, Department of Molecular Biology and Immunology, North Texas University

1996:                    Associate Biophysicist, Baylor University Medical Center at Dallas

1995–1996:           Faculty Research Associate, University of Texas at Austin

1993–1995:            Associate Biophysicist, Baylor University Medical Center at Dallas

Research

Biological physics: membrane biophysics, molecular motors, fluorescent microscopy, fluorescence polarization imaging, spectral analysis from cells, electric cell substrate impedance sensing on cells

Medical physics and nanotechnology: pH-imaging, novel approaches in drug delivery and tumor targeting, clinical fluorescent imaging and instumentation, delivery of nanopores to cancer cells, hyperthermia.

Education

1990 – 1993:     Postdoctoral   Research    Associate;   Baylor University Medical Center, Dallas.

1990:                   Ph.D. in Physics and Mathematics (Biological Physics), Moscow Institute of Physics and Technology, Moscow, Russia

1979:                   M.S. in Physics, Moscow Institute of Physics and Technology, Moscow, Russia

Publications

PUBLISHED ARTICLES (since 2006)
1. Vila-Vicosa D, Silva TFD, Slaybaugh G, Reshetnyak YK, Andreev OA, Machuqueiro M. The membrane-induced p K(a) shifts in wt-pHLIP and its L16H variant. J Chem Theory Comput (2018) doi: 10.1021/acs.jctc.8b00102. J. Chem Theory Comput.
2. Rinaldi F, Hanieh PN, Del Favero E, Rondelli V, Brocca P, Pereira MC, Andreev OA, Reshetnyak YK, Marianecci C, Carafa M. (2018) Decoration of Nanovesicles with pH (Low) Insertion Peptide (pHLIP) for Targeted Delivery. Nanoscale Res Lett., 13(1), 391.
3. Karabadzhak AG, Weerakkody D, Deacon J, Andreev OA, Reshetnyak YK, Engelman DM. Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide. Biophys J. 2018 May 8;114(9):2107-2115. doi: 10.1016/j.bpj.2018.03.036.
4. Wyatt LC, Moshnikova A, Crawford T, Engelman DM, Andreev OA and Reshetnyak YK. Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors. PNAS (2018) doi:10.1073/pnas.1715350115. PNAS
5. Mohan C. Pereira, Monica Pianella, Da Wei, Anna Moshnikova, Carlotta Marianecci, Maria Carafa, Oleg A. Andreev & Yana K. Reshetnyak (2017) pH-sensitive pHLIP® coated niosomes, Molecular Membrane Biology, 33:3-5, 51-63, DOI: 10.1080/09687688.2017.1342969
6. Daniels JL, Crawford TM, Andreev OA, and Reshetnyak YK. Synthesis and Characterization of pHLIP® Coated Gold Nanoparticles. Biochem Biophys Rep (2017) doi:10.1016/j.bbrep.2017.02.008.
7. Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, and Engelman DM. Applications of pHLIP Technology for Cancer Imaging and Therapy. Trends Biotechnol (2017) doi:10.1016/j.tibtech.2017.03.014.
8. T. Narayanan, A. D Weerakkody, Karabadzhak, M. Anderson, OA Andreev, YK Reshetnyak, pHLIP® Peptide Interaction with Phospholipid Membrane Monitored by SAXS, (2016) J Phys Chem B. 120(44):11484-11491. PMID: 27726396
9. D Weerakkody, OA Andreev, YK Reshetnyak, Insertion into Lipid Bilayer of Truncated pHLIP® peptide, Biochem Biophys Rep. (2016) Dec;8:290-295. doi: 10.1016.
10. Golijanin J, Amin A, Moshnikova A, Brito JM, Tran TY, Adochite RC, Andreev GO, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D., (2016) Targeted Imaging of Urothelium Carcinoma in Human Bladders by an ICG pHLIP peptide ex vivo., Proc Natl Acad Sci U S A., 113(42):11829-11834. PMID: 27688767
11. Demoin DW, Wyatt LC, Edwards KJ, Abdel-Atti D, Sarparanta M, Pourat J, Longo VA, Carlin SD, Engelman DM, Andreev OA, Reshetnyak YK, Viola-Villegas N, Lewis JS., (2016) PET Imaging of Extracellular pH in Tumors with (64)Cu- and (18)F-Labeled pHLIP Peptides: A Structure-Activity Optimization Study., Bioconjug Chem., 27(9):2014-23. doi: 10.1021/acs.bioconjchem.6b00306. PMID: 27396694.
12. Adochite RC, Moshnikova A, Golijanin J, Andreev OA, Katenka NV, Reshetnyak YK., (2016) Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP(®) Peptides) Conjugated with Different Fluorescent Dyes., Mol Imaging Biol. 18, 686-696.
13. Anderson M, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA., (2016) Probe for the measurement of cell surface pH in vivo and ex vivo., Proc Natl Acad Sci U S A., 113, 8177-8181.
14. D Weerakkody, A Moshnikova, NS El0Sayed, R-C Adochite, G Slaybaugh, J Golijanin, RK Tiwari, OA Andreev, K Parang, YK Reshetnyak (2016) Novel pH-sensitive cyclic peptides. Nature Sci Reports., 6:31322.
15. S. Shrestha, L. N. Cooper, O. A. Andreev, Y. K. Reshetnyak, M. P. Antosh (2016) Gold Nanoparticles for Radiation Enhancement in Vivo., J Journal of Rad. Oncology, 31, 026.
16. Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ. (2015) The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A. 112(31):9710-5.
17. Arachchige MC, Reshetnyak YK, Andreev OA. (2015) Advanced targeted nanomedicine. J Biotechnol. 202:88-97.
18. P. Antosh, D. D. Wijesinghe, S. Shrestha, R. Lanou, Y. H. Huang, T. Hasselbacher, D. Fox, N. Nerettia, S. Sun, N. Katenka, L. N. Cooper, O. A. Andreev, Y. K. Reshetnyak, (2015) Enhancement of radiation effect on cancer cells by gold-pHLIP, Proc Natl Acad Sci U S A., 112 (17), 5372-5376
19. Ganga P Sharma, Yana K Reshetnyak, Oleg A Andreev, Michael Karbach and Gerhard Müller; “Coil-helix transition of polypeptide at water-lipid interface” J. Stat. Mech. (2015).
20. Karabadzhak, A.G., An, M., Yao, L., Langenbacher, R., Moshnikova, A., Adochite, R.C., Andreev, O.A., Reshetnyak, Y.K., Engelman, D.M. (2014). pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo. ACS Chem Biol. 9(11), 2545-2553.
21. Adochite R.C., Moshnikova A., Carlin S.D., Guerrieri R.A., Andreev O.A., Lewis J.S., (2014) Reshetnyak, Y.K. Targeting Breast Tumors with pH (Low) Insertion Peptides. Mol Pharm. 11, 2896-905.
22. Viola-Villegas, N. T., S. D. Carlin, E. Ackerstaff, K. K. Sevak, V. Divilov, I. Serganova, N. Kruchevsky, M. Anderson, R. G. Blasberg, O. A. Andreev, D. M. Engelman, J. A. Koutcher, Y. K. Reshetnyak, and J. S. Lewis. (2014) Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A 111, 7254-7259.
23. Z. Cruz-Monserrate, C. L. Roland, D. Deng, T. Arumugam, A. Moshnikova, O. A. Andreev, Y. K. Reshetnyak, C. D. Logsdon (2014) Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment”, Scientific Reports, 4, 4410, 1-8.
24. D. Wijesinghe, M. C. Mallawa Arachchige, A. Lu, Y. K. Reshetnyak, O. A. Andreev (2013) Transfer of nano-pores into membrane of cancer cells induces intracellular acidification and apoptosis, Scientific Reports, Vol. 3: 3560, 1-7.
25. D. Weerakkody, A. Moshnikova, M. S. Thakur, V. Moshnikova, J. Danniels, D. M. Engelman, O. A. Andreev, Y. K. Reshetnyak A Family of pH (Low) Insertion Peptides for Tumor Targeting (2013) Proced. Natl. Acad. Sci U.S.A., 110, 15, 5834-5839.
26. L. Yao, J. Daniels, D. Wijesinghe, O. A. Andreev, Y. K. Reshetnyak, pHLIP-Mediated Delivery of PEGylated Liposomes to Cancer Cells (2013) Journal Controlled Release, 167, 228-237.
27. Moshnikova A., Moshnikova V., Andreev O.A., Reshetnyak Y.K. Anti-proliferative effect of pHLIP-amanitin (2013) Biochemistry, 52, 1171-1178.
28. Yao L, J. Daniels, A. Moshnikova, S. Kuznetsov, A Ahmed, D.M. Engelman, Y.K. Reshetnyak, O.A. Andreev (2013) The pHLIP peptide targets nanogold particles to tumors, Proced. Natl. Acad. Sci U.S.A., 110(2), 465-470.
29. Yao L, J. Daniels, A. Moshnikova, S. Kuznetsov, A Ahmed, D.M. Engelman, Y.K. Reshetnyak, O.A. Andreev (2013) The pHLIP peptide targets nanogold particles to tumors, Proced. Natl. Acad. Sci U.S.A., 110(2), 465-470.
30. E. A. Sosunov, E. P. Anyukhovsky, A. A. Sosunov, A. Moshnikova, D. Wijesinghe, D. M. Engelman, Y. K. Reshetnyak, O. A. Andreev, pHLIP targets ischemic myocardim (2013) Proced. Natl. Acad. Sci U.S.A., 110 (1), 82-86.
31. Macholl, S., Morrison, M.S., Iveson, P., Arbo, B.E., Andreev, O.A., Reshetnyak, Y.K., Engelman, D.M., Johannesen, E. (2012). In vivo pH imaging with 99mTc-pHLIP. Mol Imaging Biol., 14, 725-734.
32. Y.K. Reshetnyak, C. N. Prudence, J. Segala, V.S. Markin, O.A. Andreev (2012) Parking problem and negative cooperativity of binding of myosin subfragment 1 to F-actin, BBRC, 425, 746-749.
33. A.G. Karabadzhak, D. Weerakkody, D. Wijesinghe, M.S. Thakur, D.M. Engelman, O.A. Andreev, V.S. Markin, Y.K. Reshetnyak (2012) Modulation of the pHLIP Transmembrane Helix Insertion Pathway, Biophys Journal, 102, 1846-1855.
34. P. Daumar, C. Wanger-Baumann, N. Pillarsetty, L.A Fabrizio, S.D. Carlin, Y.K. Reshetnyak, O.A. Andreev, J. S. Lewis (2012) Efficient [18F]-Labeling of Large 37-Amino Acid pHLIP Peptide Analogues and their Biological Evaluation,”Bioconjugate Chemistry, 23, 1557-1566.
35. Wijesinghe, D. D., D. M. Engelman, O. A. Andreev and Y. K. Reshetnyak. (2011) Tuning hydrophobicity of phallacidin cargo for improved translocation across plasma membrane by pH (Low) Insertion Peptide. Biochemistry, 50, 10215-10222.
36. Y. K. Reshetnyak, L. Yao, S. Zheng, S. Kuznetsov, D. M. Engelman, O. A. Andreev (2011), Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP, Molecular Imaging and Biology, 27(7), 341–352.
37. Barrera, F. N., Weerakkody, D., Anderson, M., Andreev, O. A., Reshetnyak, Y. K. and Engelman, D. M. (2011) Roles of Carboxyl Groups in the Transmembrane Insertion of Peptides, J. Mol. Biol. 413, 359-371.
38. L Yao, J. Segala, A. J. Bucci, G. O. Andreev, Y. K. Reshetnyak, and O. A. Andreev (2010) Fluorescence Anisotropy Imaging Microscopy, Microscopy: Science, Technology, Applications and Education. Volume 4 (book chapter).
39. Y. K. Reshetnyak, L. Yao, S. Zheng, S. Kuznetsov, D. M. Engelman, O. A. Andreev (2010), Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP, Journal of Molecular Imaging and Biology, 27(7), 341–352.
40. M. An, D. Wijesinghe, O. A. Andreev, Y. K. Reshetnyak, D. M. Engelman (2010) Translocating Membrane-impermeable Toxins into Cancer Cells: pHLIP-mediated Delivery of Phalloidin Inhibits Cell Proliferation, Proced. Natl. Acad. Sci U.S.A., 107 (47), 20246-20250.
41. Andreev O.A., Engelman D. M., and Y.K. Reshetnyak (2010) pH-sensitive membrane peptides (pHLIP) as a novel class of delivery agents. Molecular Membrane Biology 27(7), 341-352. (Invited review)
42. Musial-Siwek M, Karabadzhak A, Andreev OA, Reshetnyak YK, Engelman DM. (2010) Tuning the Insertion Properties of pHLIP, BBA, 1798, 1041–1046
43. Andreev O.A., A. G. Karabadzhak, D. Weerakkody, G. O. Andreev, D. M. Engelman, Y. K. Reshetnyak (2010) The pHLIP peptide inserts across a lipid bilayer as a helix, and exits by a different path, Proced. Natl. Acad. Sci U.S.A., 107 (9), 4081-4086.
44. Yao L., G.O. Andreev, Y.K. Reshetnyak, O.A. Andreev (2009) Fabrication of semiconductor nanowires by conjugation of quantum dots to actin filaments, Anal Bional Chem. 395, 5, 1563-1566.
45. J. Segala, D.M. Engelman, Y. K. Reshetnyak and O. A. Andreev, (2009) Accurate Analysis of Tumor Margins Using a Fluorescent pH Low Insertion Peptide (pHLIP), Intern J of Mol. Sci., 10, 3478-3487 (invited paper).
46. Andreev O.A., Engelman D. M., and Y.K. Reshetnyak, (2009) Targeting acidic diseased tissue. New technology based on use of the pH (Low) Insertion Peptide (pHLIP) Chemistry Today, 27, 10-13 (invited review).
47. Vāvere A.L., Biddlecombe G.B., Spees W.M., Garbow J.R., Wijesinghe D., Andreev O.A., Engelman D.M., Reshetnyak Y.K., Lewis J.S. (2009) A Novel Technology for the Imaging of Acidic Prostate Tumors by Positron Emission Tomography, Cancer Research, 69, 4510-4516.
48. Reshetnyak Y.K., O. A. Andreev, M. Segala, V. Markin, D. Engelman (2008) Energetics of Peptide (pHLIP) binding to and folding across a lipid bilayer membrane , Proced. Natl. Acad. Sci U.S.A., 105 (40), 15340-15345.
49. Y.K. Reshetnyak, M. Segala, O. A. Andreev, D. M. Engelman (2007) A monomeric membrane peptide that lives in three worlds: in solution, attached to and inserted across lipid bilayers. Biophysical Journal, 93 (7), 2363-2672.
50. O. A. Andreev, A. D. Dupuy, M. Segala, S. Sandugu, D. A. Serra, C. O. Chichester, D. M. Engelman, Y. K. Reshetnyak (2007) Mechanism and Uses of a Peptide that Targets Tumors and other Acidic Tissue In vivo, Proced. Natl. Acad. Sci U.S.A. 104 (19) 7893-7898.
51. Andreev, O.A., & Y.K. Reshetnyak. (2007) Mechanism of formation of Actomyosin interface. J. Mol. Biol. 365 (3), 551-554.
52. Andreev O.A., Sandugu S., Engelman, D.M., Reshetnyak Y.K. (2006) Injection of Molecules into cells using a pH-triggered molecular nanosyringe. Technical Proceed. of the 2006 Nanotech Conf., 2, 57-60.
53. Reshetnyak, Y. K., Andreev, O.A., Lehnert, U., & Engelman, D.M. (2006) Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proced. Natl. Acad. Sci U.S.A. 103 (17), 6460-6465.

Awards and Honors:

2016– 2020 : NIH grant R01, GM073857, $2,282,802
2018: URI outstanding inventor
2017 : URI Research and Scholarship Excellence Award
2016: Maitland P. Simmons Memorial Research Award
2016: URI Research and Scholarship Excellence Award
2015: URI Excellence Award
2014: URI outstanding inventor
2013: URI outstanding inventor
2012: Maitland P. Simmons Memorial Research Award
2012: URI outstanding inventor
2011: Maitland P. Simmons Memorial Research Award
2010: URI outstanding inventor
2006: URI outstanding inventor

Personal website: https://physics.uri.edu/biophysics/

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