{"id":74,"date":"2025-05-16T11:48:13","date_gmt":"2025-05-16T15:48:13","guid":{"rendered":"https:\/\/web.uri.edu\/howlett-lab\/?page_id=74"},"modified":"2025-05-16T11:48:14","modified_gmt":"2025-05-16T15:48:14","slug":"publications","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/howlett-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Search for Howlett NG Publications on PubMed<\/a><\/strong><\/p>\n\n\n\n

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  1. Cantres-Velez JA, Blaize JL, Vierra DA, Boisvert RA, Garzon JL, Piraino B, Tan W, Deans AJ, Howlett NG. Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity. Mol Cell Biol. 2021 Jul 23;41(8):e0023421. doi: 10.1128\/MCB.00234-21. Epub 2021 Jul 23.\u00a0PMID: 34096775<\/a>; PMCID: PMC8300791.<\/li>\n\n\n\n
  2. Shen J, Li L, Howlett NG, Cohen PS, Sun G. Application of a Biphasic Mathematical Model of Cancer Cell Drug Response for Formulating Potent and Synergistic Targeted Drug Combinations to Triple Negative Breast Cancer Cells. Cancers (Basel). 2020 Apr 27;12(5):1087. doi: 10.3390\/cancers12051087.\u00a0PMID: 32349331<\/a>; PMCID: PMC7281712.<\/li>\n\n\n\n
  3. Shao X, Joergensen AM, Howlett NG, Lisby M, Oestergaard VH. A distinct role for recombination repair factors in an early cellular response to transcription-replication conflicts. Nucleic Acids Res. 2020 Jun 4;48(10):5467-5484. doi: 10.1093\/nar\/gkaa268.\u00a0PMID: 32329774<\/a>; PMCID: PMC7261159.<\/li>\n\n\n\n
  4. Paquin KL, Mamrak NE, Garzon JL, Cantres-Velez JA, Azzinaro PA, Vuono EA, Lima KE, Camberg JL, Howlett NG. FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair. Mol Cell Biol. 2019 Jul 16;39(15):e00194-19. doi: 10.1128\/MCB.00194-19.\u00a0PMID: 31085681<\/a>; PMCID: PMC6639249.<\/li>\n\n\n\n
  5. Higgs MR, Sato K, Reynolds JJ, Begum S, Bayley R, Goula A, Vernet A, Paquin KL, Skalnik DG, Kobayashi W, Takata M, Howlett NG, Kurumizaka H, Kimura H, Stewart GS. Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2. Mol Cell. 2018 Jul 5;71(1):25-41.e6. doi: 10.1016\/j.molcel.2018.05.018. Epub 2018 Jun 21.\u00a0PMID: 29937342<\/a>; PMCID: PMC6039718.<\/li>\n\n\n\n
  6. Paquin KL, Howlett NG. Understanding the Histone DNA Repair Code: H4K20me2 Makes Its Mark. Mol Cancer Res. 2018 Sep;16(9):1335-1345. doi: 10.1158\/1541-7786.MCR-17-0688. Epub 2018 Jun 1.\u00a0PMID: 29858375<\/a>; PMCID: PMC7083049.<\/li>\n\n\n\n
  7. Vierra DA, Garzon JL, Rego MA, Adroved MM, Mauro M, Howlett NG. Modulation of the Fanconi anemia pathway\u00a0via<\/em>\u00a0chemically induced changes in chromatin structure. Oncotarget. 2017 Jul 22;8(44):76443-76457. doi: 10.18632\/oncotarget.19470.\u00a0PMID: 29100324<\/a>; PMCID: PMC5652718.<\/li>\n\n\n\n
  8. Preiss MR, Cournoyer E, Paquin KL, Vuono EA, Belanger K, Walsh E, Howlett NG, Bothun GD. Tuning the Multifunctionality of Iron Oxide Nanoparticles Using Self-Assembled Mixed Lipid Layers. Bioconjug Chem. 2017 Nov 15;28(11):2729-2736. doi: 10.1021\/acs.bioconjchem.7b00483. Epub 2017 Oct 30.\u00a0PMID: 29035511<\/a>.<\/li>\n\n\n\n
  9. Lopez CE, Sheehan HC, Vierra DA, Azzinaro PA, Meedel TH, Howlett NG, Irvine SQ. Proteomic responses to elevated ocean temperature in ovaries of the ascidian\u00a0Ciona intestinalis<\/em>. Biol Open. 2017 Jul 15;6(7):943-955. doi: 10.1242\/bio.024786.\u00a0PMID: 28500033<\/a>; PMCID: PMC5550911.<\/li>\n\n\n\n
  10. Vuono EA, Mukherjee A, Vierra DA, Adroved MM, Hodson C, Deans AJ, Howlett NG. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016 Nov 7;6:36439. doi: 10.1038\/srep36439.\u00a0PMID: 27819275<\/a>; PMCID: PMC5098254.<\/li>\n\n\n\n
  11. Mamrak NE, Shimamura A, Howlett NG. Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia. Blood Rev. 2017 May;31(3):93-99. doi: 10.1016\/j.blre.2016.10.002. Epub 2016 Oct 13.\u00a0PMID: 27760710<\/a>; PMCID: PMC5391297.<\/li>\n\n\n\n
  12. Madireddy A, Kosiyatrakul ST, Boisvert RA, Herrera-Moyano E, Garc\u00eda-Rubio ML, Gerhardt J, Vuono EA, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL. FANCD2 Facilitates Replication through Common Fragile Sites. Mol Cell. 2016 Oct 20;64(2):388-404. doi: 10.1016\/j.molcel.2016.09.017.\u00a0PMID: 27768874<\/a>; PMCID: PMC5683400.<\/li>\n\n\n\n
  13. Paquin KL, Vierra DA, Howlett NG. A DUB-less step? Tighten up D-loop. Cell Cycle. 2016 Dec;15(23):3163-3164. doi: 10.1080\/15384101.2016.1226603. Epub 2016 Sep 14.\u00a0PMID: 27628628<\/a>; PMCID: PMC517615.<\/li>\n\n\n\n
  14. Stanley EC, Azzinaro PA, Vierra DA, Howlett NG, Irvine SQ. The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia. Evol Bioinform Online. 2016 Jun 6;12:133-48. doi: 10.4137\/EBO.S37920.\u00a0PMID: 27279728<\/a>; PMCID: PMC4898443.<\/li>\n\n\n\n
  15. Boisvert RA, Howlett NG. The Fanconi anemia ID2 complex: dueling saxes at the crossroads. Cell Cycle. 2014;13(19):2999-3015. doi: 10.4161\/15384101.2014.956475.\u00a0PMID: 25486561<\/a>; PMCID: PMC4612647.<\/li>\n\n\n\n
  16. Shirazi AN, Paquin KL, Howlett NG, Mandal D, Parang K. Cyclic peptide-capped gold nanoparticles for enhanced siRNA delivery. Molecules. 2014 Aug 28;19(9):13319-31. doi: 10.3390\/molecules190913319.\u00a0PMID: 25170952<\/a>; PMCID: PMC6271229.<\/li>\n\n\n\n
  17. Boisvert RA, Rego MA, Azzinaro PA, Mauro M, Howlett NG. Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal. PLoS One. 2013 Nov 21;8(11):e81387. doi: 10.1371\/journal.pone.0081387.\u00a0PMID: 24278431<\/a>; PMCID: PMC3836817.<\/li>\n\n\n\n
  18. Mukherjee A, Misra S, Howlett NG, Karmakar P. Multinucleation regulated by the Akt\/PTEN signaling pathway is a survival strategy for HepG2 cells. Mutat Res. 2013 Aug 15;755(2):135-40. doi: 10.1016\/j.mrgentox.2013.06.009. Epub 2013 Jun 21.\u00a0PMID: 23796964<\/a>.<\/li>\n\n\n\n
  19. Rego MA, Kolling FW 4th, Vuono EA, Mauro M, Howlett NG. Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein. Blood. 2012 Sep 6;120(10):2109-17. doi: 10.1182\/blood-2012-02-410472. Epub 2012 Jul 31.\u00a0PMID: 22855611<\/a>; PMCID: PMC3437598.<\/li>\n\n\n\n
  20. Mauro M, Rego MA, Boisvert RA, Esashi F, Cavallo F, Jasin M, Howlett NG. p21 promotes error-free replication-coupled DNA double-strand break repair. Nucleic Acids Res. 2012 Sep 1;40(17):8348-60. doi: 10.1093\/nar\/gks612. Epub 2012 Jun 26.\u00a0PMID: 22735704<\/a>; PMCID: PMC3458556.<\/li>\n\n\n\n
  21. Rego MA, Harney JA, Mauro M, Shen M, Howlett NG. Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor. Oncogene. 2012 Jan 19;31(3):366-75. doi: 10.1038\/onc.2011.237. Epub 2011 Jun 20.\u00a0PMID: 21685936<\/a>; PMCID: PMC3974337.<\/li>\n\n\n\n
  22. Cybulski KE, Howlett NG. FANCP\/SLX4: a Swiss army knife of DNA interstrand crosslink repair. Cell Cycle. 2011 Jun 1;10(11):1757-63. doi: 10.4161\/cc.10.11.15818. Epub 2011 Jun 1.\u00a0PMID: 21527828<\/a>; PMCID: PMC3142459.<\/li>\n\n\n\n
  23. Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Gu\u00e9ranger Q, Glover TW, Canman CE. Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol. 2010 Mar;30(5):1217-30. doi: 10.1128\/MCB.00993-09. Epub 2009 Dec 22.\u00a0PMID: 20028736<\/a>; PMCID: PMC2820889.<\/li>\n\n\n\n
  24. Howlett NG, Harney JA, Rego MA, Kolling FW 4th, Glover TW. Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem. 2009 Oct 16;284(42):28935-42. doi: 10.1074\/jbc.M109.016352. Epub 2009 Aug 24.\u00a0PMID: 19704162<\/a>; PMCID: PMC2781439.<\/li>\n\n\n\n
  25. Rego MA, Kolling FW 4th, Howlett NG. The Fanconi anemia protein interaction network: casting a wide net. Mutat Res. 2009 Jul 31;668(1-2):27-41. doi: 10.1016\/j.mrfmmm.2008.11.018. Epub 2008 Dec 3.\u00a0PMID: 19101576<\/a>; PMCID: PMC5578810.<\/li>\n\n\n\n
  26. Howlett NG. Fanconi anemia: Fanconi anemia, breast and embryonal cancer risk revisited. Eur J Hum Genet. 2007 Jul;15(7):715-7. doi: 10.1038\/sj.ejhg.5201860. Epub 2007 May 16.\u00a0PMID: 17505525<\/a>.<\/li>\n\n\n\n
  27. Durkin SG, Arlt MF, Howlett NG, Glover TW. Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene. 2006 Jul 27;25(32):4381-8. doi: 10.1038\/sj.onc.1209466. Epub 2006 May 29.\u00a0PMID: 16732333<\/a>.<\/li>\n\n\n\n
  28. Howlett NG, Scuric Z, D\u2019Andrea AD, Schiestl RH. Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. DNA Repair (Amst). 2006 Feb 3;5(2):251-7. doi: 10.1016\/j.dnarep.2005.10.004. Epub 2005 Nov 22.\u00a0PMID: 16309973<\/a>.<\/li>\n\n\n\n
  29. Howlett NG, Taniguchi T, Durkin SG, D\u2019Andrea AD, Glover TW. The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet. 2005 Mar 1;14(5):693-701. doi: 10.1093\/hmg\/ddi065. Epub 2005 Jan 20.\u00a0PMID: 15661754<\/a>.<\/li>\n\n\n\n
  30. Secretan MB, Scuric Z, Oshima J, Bishop AJ, Howlett NG, Yau D, Schiestl RH. Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assay. Mutat Res. 2004 Oct 4;554(1-2):351-64. doi: 10.1016\/j.mrfmmm.2004.05.016.\u00a0PMID: 15450431<\/a>.<\/li>\n\n\n\n
  31. Egorov AI, Howlett NG, Schiestl RH. Mutagen X and chlorinated tap water are recombinagenic in yeast. Mutat Res. 2004 Oct 10;563(2):159-69. doi: 10.1016\/j.mrgentox.2004.07.005.\u00a0PMID: 15364282<\/a>.<\/li>\n\n\n\n
  32. Howlett NG, Schiestl RH. Nucleotide excision repair deficiency causes elevated levels of chromosome gain in Saccharomyces cerevisiae. DNA Repair (Amst). 2004 Feb 3;3(2):127-34. doi: 10.1016\/j.dnarep.2003.10.003.\u00a0PMID: 14706346<\/a>.<\/li>\n\n\n\n
  33. Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D\u2019Andrea AD, Look AT. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell. 2003 Dec;5(6):903-14. doi: 10.1016\/s1534-5807(03)00339-3.\u00a0PMID: 14667412<\/a>.<\/li>\n\n\n\n
  34. Vonarx EJ, Howlett NG, Schiestl RH, Kunz BA. Detection of Arabidopsis thaliana AtRAD1 cDNA variants and assessment of function by expression in a yeast rad1 mutant. Gene. 2002 Aug 21;296(1-2):1-9. doi: 10.1016\/s0378-1119(02)00869-7.\u00a0PMID: 12383497<\/a>.<\/li>\n\n\n\n
  35. Howlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, De Die-Smulders C, Persky N, Grompe M, Joenje H, Pals G, Ikeda H, Fox EA, D\u2019Andrea AD. Biallelic inactivation of BRCA2 in Fanconi anemia. Science. 2002 Jul 26;297(5581):606-9. doi: 10.1126\/science.1073834. Epub 2002 Jun 13.\u00a0PMID: 12065746<\/a>.<\/li>\n\n\n\n
  36. Howlett NG, Schiestl RH. Simultaneous measurement of the frequencies of intrachromosomal recombination and chromosome gain using the yeast DEL assay. Mutat Res. 2000 Nov 6;454(1-2):53-62. doi: 10.1016\/s0027-5107(00)00097-x.\u00a0PMID: 11035159<\/a>.<\/li>\n\n\n\n
  37. Howlett NG, Avery SV. Flow cytometric investigation of heterogeneous copper-sensitivity in asynchronously grown Saccharomyces cerevisiae. FEMS Microbiol Lett. 1999 Jul 15;176(2):379-86. doi: 10.1111\/j.1574-6968.1999.tb13687.x.\u00a0PMID: 10427720<\/a>.<\/li>\n\n\n\n
  38. Howlett NG, Avery SV. Relationship between cadmium sensitivity and degree of plasma membrane fatty acid unsaturation in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 1997 Oct;48(4):539-45. doi: 10.1007\/s002530051093.\u00a0PMID: 9390462<\/a>.<\/li>\n\n\n\n
  39. Howlett NG, Avery SV. Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. Appl Environ Microbiol. 1997 Aug;63(8):2971-6. doi: 10.1128\/aem.63.8.2971-2976.1997.\u00a0PMID: 9251184<\/a>; PMCID: PMC168595.<\/li>\n\n\n\n
  40. Avery SV, Howlett NG, Radice S. Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma membrane fatty acid composition. Appl Environ Microbiol. 1996 Nov;62(11):3960-6. doi: 10.1128\/aem.62.11.3960-3966.1996.\u00a0PMID: 8899983<\/a>; PMCID: PMC168214.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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