{"id":30,"date":"2024-06-19T18:02:43","date_gmt":"2024-06-19T22:02:43","guid":{"rendered":"https:\/\/web.uri.edu\/i-cubed\/?page_id=30"},"modified":"2026-01-07T10:19:50","modified_gmt":"2026-01-07T15:19:50","slug":"research","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/i-cubed\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<p>iCubed conducts basic and translational research into the biology of infectious diseases, host-pathogen interactions, and mechanisms of disease pathogenesis.<\/p>\n\n\n<div class=\"cl-wrapper cl-card-wrapper\"><a class=\"cl-card  \" href=\"https:\/\/web.uri.edu\/i-cubed\/dengue\/\" title=\"Fluorescence microscopy image of a dengue virus-infected cell (left) showing intracellular viral proteins (blue).\"><div class=\"cl-card-container media\"><img decoding=\"async\" src=\"https:\/\/web.uri.edu\/i-cubed\/wp-content\/uploads\/sites\/2216\/4B-5-NLS_Vero_Cells_Antigen_Stain_DENV-2_100x_3_A.jpg\" srcset=\"\" alt=\"\"><\/div><div class=\"cl-card-container text\"><div class=\"cl-card-text\"><h2>Dengue<\/h2><p>Dengue is an acute viral illness transmitted by mosquitoes, mainly in tropical regions of the world. Although illness is usually mild, dengue can be life-threatening.<br><br>Our research seeks to understand how interactions between the virus and human host determine the severity of the illness.<\/p><\/div><\/div><div class=\"cl-card-container button\">Learn More<\/div><\/a><\/div>\n\n\n<h2 class=\"wp-block-heading\">Selected publications<\/h2>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Institute+for+Immunology+and+Informatics%22%5BAffiliation%5D+AND+%22University+of+Rhode+Island%22%5BAffiliation%5D&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Link to all iCubed publications in PubMed<\/em><\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vista FES, Dalmacio LMM, Solis PR, Maramba-Lazarte CNC, Lang DM, Rothman AL, de Paz-Silava SLM. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40982537\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antibody responses to Japanese encephalitis virus and dengue virus serotype 2 in children from an orthoflavivirus endemic region after IMOJEV vaccination.<\/a> PLoS Negl Trop Dis. 2025 Sep 22;19(9):e0013550. doi: 10.1371\/journal.pntd.0013550. PMID: 40982537; PMCID: PMC12463327.<\/li>\n\n\n\n<li>Sanchez-Vargas LA, Mathew A, Salje H, Sousa D, Casale NA, Farmer A, Buddhari D, Anderson K, Iamsirithaworn S, Kaewhiran S, Friberg H, Currier JR, Rothman AL.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38478732\/\" target=\"_blank\" rel=\"noreferrer noopener\">Protective Role of NS1-Specific Antibodies in the Immune Response to Dengue Virus through Antibody-Dependent Cellular Cytotoxicity.\u00a0<\/a>J Infect Dis.\u00a02024 Mar 13;.\u00a0doi: 10.1093\/infdis\/jiae137.\u00a0[Epub ahead of print]\u00a0PubMed PMID: 38478732.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Udawatte DJ, Lang DM, Currier JR, Medin CL, Rothman AL.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36310878\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dengue virus downregulates TNFR1- and TLR3-stimulated NF-\u03baB activation by targeting RIPK1.\u00a0<\/a>Front Cell Infect Microbiol.\u00a02022;12:926036.\u00a0doi: 10.3389\/fcimb.2022.926036.\u00a0eCollection 2022.\u00a0PubMed PMID: 36310878; PubMed Central PMCID: PMC9615918.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sanchez Vargas LA, Adam A, Masterson M, Smith M, Lyski ZL, Dowd KA, Pierson TC, Messer WB, Currier JR, Mathew A.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34056709\/\" target=\"_blank\" rel=\"noreferrer noopener\">Non-structural protein 1-specific antibodies directed against Zika virus in humans mediate antibody-dependent cellular cytotoxicity.\u00a0<\/a>Immunology.\u00a02021 Oct;164(2):386-397.\u00a0doi: 10.1111\/imm.13380.\u00a0Epub 2021 Jun 14.\u00a0PubMed PMID: 34056709; PubMed Central PMCID: PMC8442231.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Udawatte DJ, Rothman AL.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34372694\/\" target=\"_blank\" rel=\"noreferrer noopener\">Viral Suppression of RIPK1-Mediated Signaling.\u00a0<\/a>mBio.\u00a02021 Aug 31;12(4):e0172321.\u00a0doi: 10.1128\/mBio.01723-21.\u00a0Epub 2021 Aug 10.\u00a0Review.\u00a0PubMed PMID: 34372694; PubMed Central PMCID: PMC8406217.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>iCubed conducts basic and translational research into the biology of infectious diseases, host-pathogen interactions, and mechanisms of disease pathogenesis. Selected publications Link to all iCubed publications in PubMed<\/p>\n","protected":false},"author":884,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-30","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages\/30","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/users\/884"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/comments?post=30"}],"version-history":[{"count":4,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages\/30\/revisions"}],"predecessor-version":[{"id":145,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages\/30\/revisions\/145"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/media?parent=30"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}