{"id":43,"date":"2024-06-19T18:04:22","date_gmt":"2024-06-19T22:04:22","guid":{"rendered":"https:\/\/web.uri.edu\/i-cubed\/?page_id=43"},"modified":"2024-06-23T13:27:48","modified_gmt":"2024-06-23T17:27:48","slug":"dengue","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/i-cubed\/dengue\/","title":{"rendered":"Dengue"},"content":{"rendered":"\n<p>Dengue is an acute febrile illness caused by any of four related flaviviruses (dengue virus [DENV] serotypes 1-4). DENV infection is acquired through a transmission cycle between humans and mosquitoes of the genus Aedes, principally <em>A. aegypti<\/em>.<\/p>\n\n\n\n<p>There is a wide spectrum of clinical manifestations of dengue in humans. This ranges from an uncomplicated and self-limited febrile illness (dengue fever, DF) to a plasma leakage syndrome accompanied by bleeding (dengue hemorrhagic fever, DHF). Although DHF is observed in only a small percentage of DENV infections, it plays a large role in the public health problem of dengue because it can lead to shock and death.<\/p>\n\n\n\n<p>Many factors contribute to the risk for DHF, but one of the most important factors is pre-existing immunity from an earlier DENV infection. Infection with one DENV only provides long-lasting protection against that serotype; infection with other DENV serotypes remains possible, and, because of the increasing global circulation of DENV, is occurring with increasing frequency in tropical areas of the world.<\/p>\n\n\n\n<p>The reason for the increased risk for DHF in a second DENV infection is a major focus of our research. We hypothesize that both the quality and timing of DENV-specific antibody and T lymphocyte responses influence whether their overall effect is beneficial (controlling viral replication and reducing the severity of illness) or harmful (creating a \u2018cytokine storm\u2019 leading to plasma leakage). Our research will be applied to the management of patients with suspected dengue and the development of vaccines and therapeutics against dengue.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dengue is an acute febrile illness caused by any of four related flaviviruses (dengue virus [DENV] serotypes 1-4). DENV infection is acquired through a transmission cycle between humans and mosquitoes of the genus Aedes, principally A. aegypti. There is a wide spectrum of clinical manifestations of dengue in humans. This ranges from an uncomplicated and [&hellip;]<\/p>\n","protected":false},"author":884,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-43","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages\/43","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/users\/884"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/comments?post=43"}],"version-history":[{"count":3,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages\/43\/revisions"}],"predecessor-version":[{"id":53,"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/pages\/43\/revisions\/53"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/i-cubed\/wp-json\/wp\/v2\/media?parent=43"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}