{"id":13,"date":"2025-12-22T12:44:21","date_gmt":"2025-12-22T17:44:21","guid":{"rendered":"https:\/\/web.uri.edu\/manuel-lab\/?page_id=13"},"modified":"2026-04-08T09:36:13","modified_gmt":"2026-04-08T13:36:13","slug":"publications","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/manuel-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

*Ryan Institute affiliation<\/em><\/p>\n\n\n\n

Nascimento, Filipe, M. G\u00f6rkem \u00d6zyurt, Kareen Halablab, Gardave Singh Bhumbra, Guillaume Caron, Marcin B\u0105czyk, Daniel Zytnicki, et al. Spinal Microcircuits Go through Multiphasic Homeostatic Compensations in a Mouse Model of Motoneuron Degeneration.<\/a><\/strong> Cell Reports<\/em> 43, no. 12, 2024. <\/p>\n\n\n\n

Reedich EJ,* Genry LT,* Steele PR,* Mena Avila E,* Dowaliby L,* Drobyshevsky A, Manuel M,* Quinlan KA.* Spinal Motoneurons Respond Aberrantly to Serotonin in a Rabbit Model of Cerebral Palsy.<\/strong><\/a>  J Physiol., 2023. <\/p>\n\n\n\n

Cavarsan CF,* Steele PR,* Genry LT,* Reedich EJ,* McCane LM,* LaPre KJ,* Puritz AC,* Manuel M,* Katenka N, Quinlan KA. Inhibitory Interneurons Show Early Dysfunction in a SOD1 Mouse Model of Amyotrophic Lateral Sclerosis<\/a>.<\/strong> J Physiol., 2023. <\/p>\n\n\n\n

Fran\u00e7a de Barros F, Bacqu\u00e9-Cazenave J, Taillebuis C, Courtand G, Manuel M*, Bras H, Tagliabue M, Combes D, Lambert FM, Beraneck M. Conservation of locomotion-induced oculomotor activity through evolution in mammals. <\/a><\/strong>Curr Biol. 2022 Jan 24;32(2):453-461.e4. doi: 10.1016\/j.cub.2021.11.022<\/p>\n\n\n\n

Manuel M, Zytnicki D. Comments on the article by Jensen et al. (2020). <\/a>J Physiol. 2021 Sep;599(17):4231-4232. doi: 10.1113\/JP281461<\/p>\n\n\n\n

Huh S, Heckman CJ, Manuel M. Time Course of Alterations in Adult Spinal Motoneuron Properties in the SOD1(G93A) Mouse Model of ALS. <\/a><\/strong>eNeuro. 2021 Mar-Apr;8(2). doi: 10.1523\/ENEURO.0378-20.2021<\/p>\n\n\n\n

Manuel M. Suboptimal Discontinuous Current-Clamp Switching Rates Lead to Deceptive Mouse Neuronal Firing. <\/a><\/strong>eNeuro. 2021 Jan-Feb;8(1). doi: 10.1523\/ENEURO.0461-20.2020<\/p>\n\n\n\n

B\u0105czyk M, Alami NO, Delestr\u00e9e N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D. Synaptic restoration by cAMP\/PKA drives activity-dependent neuroprotection to motoneurons in ALS. <\/a><\/strong>J Exp Med. 2020 Aug 3;217(8). doi: 10.1084\/jem.20191734<\/p>\n\n\n\n

Manuel M, Zytnicki D. Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes. <\/a><\/strong>Curr Opin Physiol. 2019 Apr;8:23-29. doi: 10.1016\/j.cophys.2018.11.008<\/p>\n\n\n\n

Manuel M, Chardon M, Tysseling V, Heckman CJ. Scaling of Motor Output, From Mouse to Humans. <\/a><\/strong>Physiology (Bethesda). 2019 Jan 1;34(1):5-13. doi: 10.1152\/physiol.00021.2018<\/p>\n\n\n\n

Mart\u00ednez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M. Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS. <\/a><\/strong>Elife. 2018 Mar 27;7. doi: 10.7554\/eLife.30955<\/p>\n\n\n\n

Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F. Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion. <\/a><\/strong>Cell Rep. 2018 Mar 20;22(12):3315-3327<\/p>\n\n\n\n

Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C. Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve. <\/a><\/strong>Sci Rep. 2018 Feb 6;8(1):2524. doi: 10.1038\/s41598-018-20980-3 <\/p>\n\n\n\n

Tysseling VM, Klein DA, Imhoff-Manuel R, Manuel M, Heckman CJ, Tresch MC. Constitutive activity of 5-HT(2C) receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment. <\/a><\/strong>J Neurophysiol. 2017 Nov 1;118(5):2944-2952. doi: 10.1152\/jn.00190.2017<\/p>\n\n\n\n

Huh S, Siripuram R, Lee RH, Turkin VV, O\u2019Neill D, Hamm TM, Heckman CJ, Manuel M. PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species. <\/a><\/strong>J Neurophysiol. 2017 Jul 1;118(1):93-102. doi: 10.1152\/jn.00045.2017<\/p>\n\n\n\n

Meehan CF, Mayr KA, Manuel M, Nakanishi ST, Whelan PJ. Decerebrate mouse model for studies of the spinal cord circuits. <\/a><\/strong>Nat Protoc. 2017 Apr;12(4):732-747. doi: 10.1038\/nprot.2017.001<\/p>\n\n\n\n

Gen\u00e7 B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, \u00d6zdinler PH. Absence of UCHL 1 function leads to selective motor neuropathy. <\/a><\/strong>Ann Clin Transl Neurol. 2016 May;3(5):331-45. doi: 10.1002\/acn3.298<\/p>\n\n\n\n

Mess\u00e9ant J, Dobbertin A, Girard E, Delers P, Manuel M, Mangione F, Schmitt A, Le Denmat D, Molg\u00f3 J, Zytnicki D, Schaeffer L, Legay C, Strochlic L. MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.<\/strong> <\/a>J Neurosci. 2015 Mar 25;35(12):4926-41. doi: 10.1523\/JNEUROSCI.3381-14.2015.   <\/p>\n\n\n\n

Ritter LK, Tresch MC, Heckman CJ, Manuel M, Tysseling VM. Characterization of motor units in behaving adult mice shows a wide primary range. <\/a><\/strong>J Neurophysiol. 2014 Aug 1;112(3):543-51. doi: 10.1152\/jn.00108.2014<\/p>\n\n\n\n

Delestr\u00e9e N, Manuel M, Iglesias C, Elbasiouny SM, Heckman CJ, Zytnicki D. Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis. <\/a><\/strong>J Physiol. 2014 Apr 1;592(7):1687-703. doi: 10.1113\/jphysiol.2013.265843<\/p>\n\n\n\n

Manuel M, Zytnicki D, Meunier C. The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons. <\/a><\/strong>Front Comput Neurosci. 2014;8:4. doi: 10.3389\/fncom.2014.00004<\/p>\n\n\n\n

Manuel M, Heckman CJ. Simultaneous intracellular recording of a lumbar motoneuron and the force produced by its motor unit in the adult mouse in vivo. <\/a><\/strong>J Vis Exp. 2012 Dec 5;(70):e4312. doi: 10.3791\/4312<\/p>\n\n\n\n

Manuel M, Li Y, Elbasiouny SM, Murray K, Griener A, Heckman CJ, Bennett DJ. NMDA induces persistent inward and outward currents that cause rhythmic bursting in adult rodent motoneurons. <\/a><\/strong>J Neurophysiol. 2012 Dec;108(11):2991-8. doi: 10.1152\/jn.00518.2012 <\/p>\n\n\n\n

Johnson MD, Hyngstrom AS, Manuel M, Heckman CJ. Push-pull control of motor output. <\/a><\/strong>J Neurosci. 2012 Mar 28;32(13):4592-9. doi: 10.1523\/JNEUROSCI.4709-11.2012<\/p>\n\n\n\n

Manuel M, Heckman CJ. Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment? <\/a><\/strong>J Neurosci. 2011 Oct 19;31(42):15188-94. doi: 10.1523\/JNEUROSCI.2893-11.2011<\/p>\n\n\n\n

Manuel M, Zytnicki D. Alpha, beta and gamma motoneurons: functional diversity in the motor system\u2019s final pathway.<\/strong> <\/a>J Integr Neurosci. 2011 Sep;10(3):243-76. doi: 10.1142\/S0219635211002786<\/p>\n\n\n\n

Frigon A, Thompson CK, Johnson MD, Manuel M, Hornby TG, Heckman CJ. Extra forces evoked during electrical stimulation of the muscle or its nerve are generated and modulated by a length-dependent intrinsic property of muscle in humans and cats. <\/a><\/strong>J Neurosci. 2011 Apr 13;31(15):5579-88. doi: 10.1523\/JNEUROSCI.6641-10.2011<\/p>\n\n\n\n

Iglesias C, Meunier C, Manuel M, Timofeeva Y, Delestr\u00e9e N, Zytnicki D. Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state. <\/a><\/strong>J Neurosci. 2011 Apr 13;31(15):5829-40. doi: 10.1523\/JNEUROSCI.6363-10.2011<\/p>\n\n\n\n

Manuel M, Heckman CJ. Stronger is not always better: could a bodybuilding dietary supplement lead to ALS?<\/strong> <\/a>Exp Neurol. 2011 Mar;228(1):5-8. doi: 10.1016\/j.expneurol.2010.12.007<\/p>\n\n\n\n

Manuel M, Iglesias C, Donnet M, Leroy F, Heckman CJ, Zytnicki D. Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons. <\/a><\/strong>J Neurosci. 2009 Sep 9;29(36):11246-56. doi: 10.1523\/JNEUROSCI.3260-09.2009 <\/p>\n\n\n\n

Manuel M, Meunier C, Donnet M, Zytnicki D. Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons.<\/strong> <\/a>J Neurosci. 2007 Nov 21;27(47):12977-88. doi: 10.1523\/JNEUROSCI.3299-07.2007<\/p>\n\n\n\n

Manuel M, Meunier C, Donnet M, Zytnicki D. The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats. <\/a><\/strong>J Physiol. 2006 Nov 1;576(Pt 3):873-86. doi: 10.1113\/jphysiol.2006.117002<\/p>\n","protected":false},"excerpt":{"rendered":"

*Ryan Institute affiliation Nascimento, Filipe, M. G\u00f6rkem \u00d6zyurt, Kareen Halablab, Gardave Singh Bhumbra, Guillaume Caron, Marcin B\u0105czyk, Daniel Zytnicki, et al. Spinal Microcircuits Go through Multiphasic Homeostatic Compensations in a Mouse Model of Motoneuron Degeneration. Cell Reports 43, no. 12, 2024.  Reedich EJ,* Genry LT,* Steele PR,* Mena Avila E,* Dowaliby L,* Drobyshevsky A, Manuel M,* Quinlan KA.* Spinal […]<\/p>\n","protected":false},"author":5285,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-13","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/pages\/13","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/users\/5285"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/comments?post=13"}],"version-history":[{"count":5,"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/pages\/13\/revisions"}],"predecessor-version":[{"id":132,"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/pages\/13\/revisions\/132"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/manuel-lab\/wp-json\/wp\/v2\/media?parent=13"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}