{"id":448,"date":"2019-03-23T23:33:26","date_gmt":"2019-03-24T03:33:26","guid":{"rendered":"https:\/\/web.uri.edu\/ncipher\/?p=448"},"modified":"2025-10-16T13:52:32","modified_gmt":"2025-10-16T17:52:32","slug":"generalizing-evidence-from-randomized-trials-using-inverse-probability-of-sampling-weights","status":"publish","type":"post","link":"https:\/\/web.uri.edu\/ncipher\/generalizing-evidence-from-randomized-trials-using-inverse-probability-of-sampling-weights\/","title":{"rendered":"Generalizing Evidence from Randomized Trials using Inverse Probability of Sampling Weights"},"content":{"rendered":"<p>This paper describes the use of inverse probability of sampling weights which are used to adjust the results of clinical trials to generalize to a given population of interest.<\/p>\n<p><!--more--><\/p>\n<p>Results obtained in randomized trials may not easily generalize to target populations. Whereas in randomized<br \/>\ntrials the treatment assignment mechanism is known, the sampling mechanism by which individuals<br \/>\nare selected to participate in the trial is typically not known and assuming random sampling from<br \/>\nthe target population is often dubious. We consider an inverse probability of sampling weighted (IPSW)<br \/>\nestimator for generalizing trial results to a target population. The IPSW estimator is shown to be consistent<br \/>\nand asymptotically normal. A consistent sandwich-type variance estimator is derived and simulation<br \/>\nresults are presented comparing the IPSW estimator to a previously proposed stratified estimator. The<br \/>\nmethods are then utilized to generalize results from two randomized trials of HIV treatment to all people<br \/>\nliving with HIV in the US.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30555215\/\">Generalizing Evidence from Randomized Trials using Inverse Probability of Sampling Weights<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This paper describes the use of inverse probability of sampling weights which are used to adjust the results of clinical trials to generalize to a given population of interest.<\/p>\n","protected":false},"author":4688,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[14],"tags":[],"class_list":["post-448","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/posts\/448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/users\/4688"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/comments?post=448"}],"version-history":[{"count":5,"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/posts\/448\/revisions"}],"predecessor-version":[{"id":1259,"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/posts\/448\/revisions\/1259"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/media?parent=448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/categories?post=448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.uri.edu\/ncipher\/wp-json\/wp\/v2\/tags?post=448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}