- Assistant Professor
- Office: 395N Lab: 330
- Phone: 401.874.5517
- Email: email@example.com
- Office Location: 7 Greenhouse Road, Kingston, RI 02881
Particles can be engineered with nanometer-size which are only 1/1,000 the width of a single human hair. These nanoparticles possess versatility in biomedical applications.
The aim of Dr. Lu’s research is to develop new nanomedicines, especially to apply nanotechnology to cancer diagnosis and therapeutics. From nanotechnology to biomedical application and pharmaceutical development, the intent is to seek the potentials for clinical translation, which includes photothermal therapy, molecular imaging, controlled release of chemotherapeutic agents and nucleic acids for cancer theranostics.
Besides, Dr. Lu is involved in research projects for new formulation development including various sustained and/or site-specific oral drug delivery systems, as well as intranasal and transdermal delivery systems for macromolecular drugs, in order to improve the bioavailability and reduce the side effects of the drug.
Nanomedicine; drug delivery; new formulation development
Post-doctoral Fellow, The University of Texas M.D. Anderson Cancer Center, 2006-2009
Ph.D., Fudan University, Shanghai, China, 2005
B.S., Fudan University, Shanghai, China, 2000
Lu W. (2012) Adsorptive-Mediated Brain Delivery Systems. Current Pharmaceutical Biotechnology, 13(12), 2340-2348.
Ramadan, S., Guo, L., Li, Y., Yan, B. & Lu, W. (2012). Hollow copper sulfide nanoparticle-mediated transdermal drug delivery. Small, 8(20), 3143-3150.
Lu, W., Melancon, M.P., Xiong, C., Huang, Q., Elliott, A., Song, S., Zhang, R., Flores, L.G. 2nd, Gelovani, J.G., Wang, L.V., Ku, G., Stafford, R.J. & Li, C. (2011). Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Research, 71(19), 6116-6121.
Lu, W., Zhang, G., Zhang, R., Flores, L.G., Huang, Q., Gelovani, J.G. & Li, C. (2010). Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection. Cancer Research, 70(8), 3177-3188.
Lu, W., Huang, Q., Ku, G., Wen, X., Zhou, M., Guzatov, D., Brecht, P., Su, R., Oraevsky, A., Wang, L.V. & Li, C. (2010). Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials, 31(9), 2617-2626.
Lu, W., Xiong, C., Zhang, G., Huang, Q., Zhang, R., Zhang, J.Z. & Li, C. (2009). Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres. Clinical Cancer Research, 15(3), 876-886.
Lu, W., Sun, Q., Wan, J., She, Z. & Jiang, X.G. (2006). Cationic albumin-conjugated pegylated nanoparticles allow gene delivery into brain tumors via intravenous administration. Cancer Research, 66(24), 11878-11887.
Lu, W., Zhang, Y., Tan, Y.Z., Hu, K.L., Jiang, X.G. & Fu S.K. (2005). Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery. Journal of Controlled Release, 107(3), 428-448.