{"id":11556,"date":"2013-10-07T14:30:00","date_gmt":"2013-10-07T14:30:00","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=11556"},"modified":"2019-07-31T10:01:51","modified_gmt":"2019-07-31T14:01:51","slug":"rowley","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rowley\/","title":{"rendered":"Dr. David Rowley- Natural Products"},"content":{"rendered":"<p><section class=\"cl-wrapper cl-hero-wrapper\"><div class=\"cl-hero super   cl-has-accessibility-controls\"><div class=\"cl-hero-proper\"><div class=\"overlay\"><div class=\"block\"><h1>Natural Product Drug Discovery Research<\/h1><p>Located in Lab Module 430 on Level 4 of Avedisian Hall<\/p><\/div><\/div><div class=\"still\" style=\"background-image:url(https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1223\/bsps2-1.jpg);\"><\/div><div class=\"cl-accessibility-controls-container\"><div class=\"cl-accessibility-controls\"><div class=\"cl-accessibility-icon\" title=\"Accessibility controls\">Accessibility controls<\/div><div class=\"cl-accessibility-control cl-accessibility-motion-control cl-accessibility-control-hidden\"><div class=\"cl-accessibility-control-default\"><div class=\"cl-accessibility-control-button\" title=\"Pause motion\">Pause motion<\/div><div class=\"cl-accessibility-control-label\">Motion: <span class=\"cl-accessibility-syntax\">On<\/span><\/div><\/div><div class=\"cl-accessibility-control-alternate\"><div class=\"cl-accessibility-control-button\" title=\"Play motion\">Play motion<\/div><div class=\"cl-accessibility-control-label\">Motion: <span class=\"cl-accessibility-syntax\">Off<\/span><\/div><\/div><\/div><div class=\"cl-accessibility-control cl-accessibility-contrast-control\"><div class=\"cl-accessibility-control-default\"><div class=\"cl-accessibility-control-button\" title=\"Increase text contrast\">Increase text contrast<\/div><div class=\"cl-accessibility-control-label\">Contrast: <span class=\"cl-accessibility-syntax\">Standard<\/span><\/div><\/div><div class=\"cl-accessibility-control-alternate\"><div class=\"cl-accessibility-control-button\" title=\"Reset text contrast\">Reset text contrast<\/div><div class=\"cl-accessibility-control-label\">Contrast: <span class=\"cl-accessibility-syntax\">High<\/span><\/div><\/div><\/div><div class=\"cl-accessibility-system-setting\"><div class=\"cl-accessibility-toggle\" title=\"Apply my preferences site-wide\"><\/div><div class=\"cl-accessibility-toggle-label\">Apply site-wide<\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"cl-wrapper cl-tabs-wrapper\"><div class=\"cl-tabs  \"><section class=\"cl-tab \"><h1>Overview<\/h1><\/p>\n<p><em><strong>Expertise<\/strong>: Microorganisms from unexplored environments; secondary metabolites produced by marine microbes; bacterial chemical communication; and antibiotic drug discovery<\/em><\/p>\n<p>One of the more frightening medical trends today is our growing resistance to antibiotics, which we take for everything from ear infections to life-threatening blood conditions. As people use antibiotics for more and more ailments, the ability of germs and bacteria to mutate and adapt has increased, often making them stronger than the medicines available to treat them.<\/p>\n<p>Pharmacognosy is the study of the medicinal properties of compounds from such natural sources as the ocean and plants. Most of our current antibiotic drugs derive from natural products produced by terrestrial microorganisms, so as we try to stay one step ahead of the pathogens, the most logical next place to look is at marine microbes. <a title=\"Big Thinkers: David Rowley\" href=\"https:\/\/web.uri.edu\/pharmacy\/2013\/10\/07\/big-thinkers-david-rowley\/\">[Continued&#8230;]<\/a><\/p>\n<hr>\n<h2>News<\/h2>\n<ul class=\"display-posts-listing\"><li class=\"listing-item\"><a class=\"image\" href=\"https:\/\/web.uri.edu\/pharmacy\/2015\/10\/15\/professor-rowley-and-team-say-class-of-cranberry-carbohydrates-could-improve-uti-treatment\/\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/IMG_0432-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/IMG_0432-150x150.jpg 150w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/IMG_0432-125x125.jpg 125w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a> <a class=\"title\" href=\"https:\/\/web.uri.edu\/pharmacy\/2015\/10\/15\/professor-rowley-and-team-say-class-of-cranberry-carbohydrates-could-improve-uti-treatment\/\">Professor Rowley and team say class of cranberry carbohydrates could improve UTI treatment<\/a> <span class=\"excerpt-dash\">-<\/span> <span class=\"excerpt\">Biomedical Science Professor David Rowley and his team in the College of Pharmacy have found that a class of complex carbohydrates could enhance treatment of urinary tract infections. Their findings appear in a recent issue of the Journal of Functional Foods, published by the International Society for Nutraceuticals and Functional Foods. <\/span><\/li><li class=\"listing-item\"><a class=\"image\" href=\"https:\/\/www.uri.edu\/news\/index.php?today=2014-06-04\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"114\" src=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Inbre-logo-150x114.jpg\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" \/><\/a> <a class=\"title\" href=\"https:\/\/www.uri.edu\/news\/index.php?today=2014-06-04\">$18.8 Million for URI-Based Initiative<\/a> <span class=\"excerpt-dash\">-<\/span> <span class=\"excerpt\">The Rhode Island IDeA Network of Biomedical Research Excellence (RI-INBRE), the URI-based initiative that has greatly expanded biomedical research statewide, has been awarded an additional $18.8 million for the program\u2019s continued expansion over the next five years. Professor of Pharmacology and Toxicology Zahir Shaikh has been the principal investigator and program director since the project's inception in 2001.<\/span><\/li><li class=\"listing-item\"><a class=\"image\" href=\"https:\/\/web.uri.edu\/pharmacy\/2013\/10\/07\/discover-new-cures\/\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/zawiA-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/zawiA-150x150.jpg 150w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/zawiA-125x125.jpg 125w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a> <a class=\"title\" href=\"https:\/\/web.uri.edu\/pharmacy\/2013\/10\/07\/discover-new-cures\/\">Discover New Cures.<\/a> <span class=\"excerpt-dash\">-<\/span> <span class=\"excerpt\">Discover New Cures. The world\u2019s got a lot of illness and disease that needs curing, and at URI, leading scientists are breaking new ground toward the discoveries we\u2019ve all been waiting for. Inside our Natural Products Lab, Pharmacognosy Professor David Rowley \u2013 one of the only a handful of marine microbial chemists in the world [&hellip;]<\/span><\/li><li class=\"listing-item\"><a class=\"image\" href=\"https:\/\/web.uri.edu\/pharmacy\/2013\/10\/07\/big-thinkers-david-rowley\/\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Dave-Rowley-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Dave-Rowley-150x150.jpg 150w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Dave-Rowley-125x125.jpg 125w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Dave-Rowley-80x80.jpg 80w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Dave-Rowley-e1710260705490.jpg 185w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a> <a class=\"title\" href=\"https:\/\/web.uri.edu\/pharmacy\/2013\/10\/07\/big-thinkers-david-rowley\/\">Big Thinkers: David Rowley<\/a> <span class=\"excerpt-dash\">-<\/span> <span class=\"excerpt\">Title: Associate Professor, Biomedical Sciences Expertise: Microorganisms from unexplored environments; secondary metabolites produced by marine microbes; bacterial chemical communication; and antibiotic drug discovery One of the more frightening medical trends today is our growing resistance to antibiotics, which we take for everything from ear infections to life-threatening blood conditions. As people use antibiotics for more [&hellip;]<\/span><\/li><li class=\"listing-item\"><a class=\"image\" href=\"https:\/\/web.uri.edu\/pharmacy\/2013\/08\/13\/discover-the-healing-power-of-the-sea\/\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/research-lab-photo-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/research-lab-photo-150x150.png 150w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/research-lab-photo-125x125.png 125w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a> <a class=\"title\" href=\"https:\/\/web.uri.edu\/pharmacy\/2013\/08\/13\/discover-the-healing-power-of-the-sea\/\">Discover the Healing Power of the Sea<\/a> <span class=\"excerpt-dash\">-<\/span> <span class=\"excerpt\">In science, amazing discoveries can begin in familiar places\u2014in the ocean, in the plants around us, just about anywhere in the natural world. And at URI, that\u2019s exactly where a group of scientists and their students are looking for newer and more effective medicines to treat infection and a variety of human diseases.Pharmacognosy Professor David [&hellip;]<\/span><\/li><li class=\"listing-item\"><a class=\"image\" href=\"https:\/\/web.uri.edu\/pharmacy\/2008\/02\/25\/uris-college-of-pharmacy-bolsters-natural-products-chemistry-work\/\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/22-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/22-150x150.jpg 150w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/22-125x125.jpg 125w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a> <a class=\"title\" href=\"https:\/\/web.uri.edu\/pharmacy\/2008\/02\/25\/uris-college-of-pharmacy-bolsters-natural-products-chemistry-work\/\">URI\u2019s College of Pharmacy bolsters natural products chemistry work<\/a> <span class=\"excerpt-dash\">-<\/span> <span class=\"excerpt\">Discovering drugs from natural sources part of College\u2019s 50-year history KINGSTON, R.I. \u2013 February 25, 2008 \u2013 After it opened its doors in 1957, the University of Rhode Island\u2019s College of Pharmacy quickly became known for its medicinal plant research. Fifty years later, the College is strengthening its work in pharmacognosy, a branch of pharmacy [&hellip;]<\/span><\/li><li class=\"listing-item\"><a class=\"image\" href=\"https:\/\/web.uri.edu\/pharmacy\/2005\/07\/06\/uri-to-host-conference-birthday-bash-in-honor-of-drugs-from-the-sea-pioneer\/\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Shimizu-web--150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Shimizu-web--150x150.jpg 150w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Shimizu-web--125x125.jpg 125w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/Shimizu-web--80x80.jpg 80w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a> <a class=\"title\" href=\"https:\/\/web.uri.edu\/pharmacy\/2005\/07\/06\/uri-to-host-conference-birthday-bash-in-honor-of-drugs-from-the-sea-pioneer\/\">URI to host conference, birthday bash in honor of \u2018drugs from the sea\u2019 pioneer<\/a> <span class=\"excerpt-dash\">-<\/span> <span class=\"excerpt\">Kingston resident Yuzuru Shimizu to be feted KINGSTON, R.I. &#8212; July 6, 2005 &#8212; How do you celebrate the 70th birthday of a University of Rhode Island professor who is renowned for his research on obtaining drugs from the sea? You simply invite his colleagues, friends and former students from around the world to a [&hellip;]<\/span><\/li><\/ul>\n<p><\/section><\/p>\n<section class=\"cl-tab \"><h1>Research<\/h1><\/p>\n<p>\n<!-- iframe plugin v.6.0 wordpress.org\/plugins\/iframe\/ -->\n<iframe loading=\"lazy\" width=\"100%\" 0=\"height=&quot;400\" src=\"\/\/www.youtube.com\/embed\/f4N2JdOs_9M?rel=0\" frameborder=\"0\" 1=\"allowfullscreen\" height=\"500\" scrolling=\"yes\" class=\"iframe-class\"><\/iframe>\n<\/p>\n<p><\/section>\n<section class=\"cl-tab \"><h1>Publications<\/h1>\n<p>Choi H, Mascuch SJ, Villa FA, Byrum T, Teasdale ME, Smith JE, Preskitt LB, Rowley DC, Gerwick L, Gerwick WH. (2012) Honaucins A?C, Potent inhibitors of eukaryotic inflammation and bacterial quorum sensing: Synthetic derivatives and structure-activity relationships, Chemistry &amp; Biology, 19(5):589-98.<\/p>\n<p>Sarkisian SA, Janssen MJ, Matta H, Henry GE, Laplante KL, Rowley DC (2012) Inhibition of bacterial growth and biofilm production by constituents from Hypericum spp. Phytotherapy Research 26(7):1012-6. doi: 10.1002\/ptr.3675.<\/p>\n<p>Teasdale M, Donovan KA, Forschner-Dancause SR, Rowley DC (2010) Gram-positive marine bacteria as a potential resource for the discovery of quorum sensing inhibitors. Marine Biotechnology, DOI: 10.1007\/s10126-010-9334-7.<\/p>\n<p>Teasdale M, Liu J, Wallace J, Rowley DC (2009) Secondary metabolites produced by a marine Halobacillus salinus that inhibit quorum sensing controlled phenotypes in Gram-negative bacteria. Applied and Environmental Microbiology, 75(3): 567-572.<\/p>\n<p>Socha AM, LaPlante KL, Russell DJ, Rowley DC (2009) Structure-activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis. Bioorganic and Medicinal Chemistry Letters, 19: 1504-1507.<\/p>\n<p>Forschner S, Sheffer R, Rowley DC, Smith D (2009) Microbial diversity of deeply buried Arctic prokaryotic communities. Environmental Microbiology, 11(3): 630-639.<\/p>\n<p>Socha AM, Long RA, Rowley DC (2007) New bacillamides from a hypersaline microbial mat bacterium. Journal of Natural Products, 70:1793-1795.<\/p>\n<p>Socha AM, LaPLante KL, Rowley DC. (2006) New bisanthraquinone antibiotics and semi-synthetic derivatives with potent activity against clinical Staphylococcus aureus and Enterococcus faecium isolates. Bioorganic and Medicinal Chemistry, 14(24):8446-54.<\/p>\n<p><\/section><section class=\"cl-tab \"><h1>David Rowley, Ph.D.<\/h1><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2483 size-thumbnail alignright\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1223\/david_rowley_web-150x150.jpg\" alt=\"David Rowley\" width=\"150\" height=\"150\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/david_rowley_web-150x150.jpg 150w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/david_rowley_web-125x125.jpg 125w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/david_rowley_web-80x80.jpg 80w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/david_rowley_web.jpg 200w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<ul class=\"people-list\">\n<li class=\"people-title\">Professor<\/li>\n<li class=\"people-department\">Office: 245A Lab: 430<\/li>\n<li class=\"people-phone\"><strong>Phone:&nbsp;<\/strong>401.874.9228<\/li>\n<li class=\"people-email\"><strong>Email:&nbsp;<a href=\"mailto:drowley@uri.edu\">drowley@uri.edu<\/a><\/strong><\/li>\n<\/ul>\n<a class=\"cl-button  \" href=\"https:\/\/web.uri.edu\/pharmacy\/meet\/david-rowley\/\" title=\"\">Full Bio<\/a>\n<p>&nbsp;<\/p>\n<p><\/section><\/p>\n<p><\/div><\/section><\/p>\n<p>&nbsp;<\/p>\n\n","protected":false},"excerpt":{"rendered":"<p>&nbsp;<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":63,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-11556","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/11556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=11556"}],"version-history":[{"count":6,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/11556\/revisions"}],"predecessor-version":[{"id":41291,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/11556\/revisions\/41291"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/63"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=11556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}