{"id":25072,"date":"2016-08-15T19:34:48","date_gmt":"2016-08-15T19:34:48","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25072"},"modified":"2019-01-17T15:32:33","modified_gmt":"2019-01-17T20:32:33","slug":"model2","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model2\/","title":{"rendered":"Model 2: Simple Drug Transporter Model"},"content":{"rendered":"
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The major uptake and efflux transporters present in the intestinal, hepatocyte and renal tubular membranes are shown. Examples of transporters at the various sites can be seen by clicking on a transporter symbol. The model will simulate plasma concentrations after oral or IV doses. Individual transporters may be turned off to observe how they influence drug concentrations.<\/h2><\/div><\/div>
View Model<\/div><\/a><\/div>\n

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See Chapter 2: Passage of Drugs Through Membranes
\nTopics relevant to this model are covered in the following sections:<\/h3>\n

\u2013 2.4.1 Uptake Transporters: SLC Superfamily
\n\u2013 2.4.2 Efflux Transporters: ABC Superfamily
\n\u2013 2.4.3 Characteristics of Transporter Systems
\n\u2013 2.4.4 Simulation Exercise<\/p>\n

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