{"id":25080,"date":"2016-08-15T19:39:06","date_gmt":"2016-08-15T19:39:06","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25080"},"modified":"2019-01-17T15:47:46","modified_gmt":"2019-01-17T20:47:46","slug":"model6","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model6\/","title":{"rendered":"Model 6: First Order Absorption in a 1-Compartment Model: A Single Oral Dose"},"content":{"rendered":"<div class=\"cl-wrapper cl-card-wrapper\"><a class=\"cl-card  \" href=\"https:\/\/exchange.iseesystems.com\/public\/sara-rosenbaum\/oral-absorption\/index.html#page1\" title=\"\"><div class=\"cl-card-container media\"><img decoding=\"async\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1223\/model6.jpg\" srcset=\"\" alt=\"support\"><\/div><div class=\"cl-card-container text\"><div class=\"cl-card-text\"><h2>This model shows the characteristics of a single oral dose with first order absorption in a one compartment model. The model demonstrates the determinants of the peak plasma concentration, the time to reach the peak and area under the curve. Additionally the model illustrates how absorption, and not elimination controls the fall in the plasma concentration when absorption is very slow (Flip flop model).<\/h2><\/div><\/div><div class=\"cl-card-container button\">View Model<\/div><\/a><\/div>\n<h3>See Chapter 9: PK of Extravascular Drug Administration<br \/>\nTopics relevant to this model are covered in the following sections:<\/h3>\n<p>\u2013 9.6 Simulation Exercise<\/p>\n<p>&nbsp;<\/p>\n<ul class=\"display-posts-listing\"><li class=\"listing-item\"><div class=\"content\"><section class=\"cl-wrapper cl-panel-wrapper\"><div class=\"cl-panel  \"><figure><img decoding=\"async\" src=\"https:\/\/images-na.ssl-images-amazon.com\/images\/I\/51%2BFYUXkqWL._SX348_BO1,204,203,200_.jpg\" srcset=\"\" alt=\"cholab\"><\/figure><article><h1>Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/h1><p><b>By: Sara E. Rosenbaum, Ph.D.<\/B><br \/>\nAn Integrated Textbook with Computer Simulations, which provides a comprehensive  account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p><a class=\"cl-button  \" href=\"https:\/\/www.amazon.com\/Basic-Pharmacokinetics-Pharmacodynamics-Integrated-Simulations\/dp\/1119143152?_encoding=UTF8&amp;ie=UTF8&amp;message=&amp;riskType=expiredCard&amp;successUpdatingPreference=1&amp;updatePaymentsPortalPreferenceSuccess=true\" title=\"\">Purchase from Amazon<\/a><\/p><\/article><\/div><\/section>\n<\/div><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; See Chapter 9: PK of Extravascular Drug Administration Topics relevant to this model are covered in the following sections: \u2013 9.6 Simulation Exercise &nbsp;<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25080","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25080"}],"version-history":[{"count":3,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25080\/revisions"}],"predecessor-version":[{"id":37379,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25080\/revisions\/37379"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}