{"id":25082,"date":"2016-08-15T19:39:41","date_gmt":"2016-08-15T19:39:41","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25082"},"modified":"2019-01-17T15:49:52","modified_gmt":"2019-01-17T20:49:52","slug":"model7","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model7\/","title":{"rendered":"Model 7: Constant Continuous Drug Administration"},"content":{"rendered":"
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This model shows the plasma concentration profile associated with constant continuous drug administration. Examples of this type of administration include the IV infusion, certain oral formulations and certain transdermal patches. The model demonstrates the determinants of the steady state plasma concentration, the time to reach steady state, the administration of loading doses, and the fall in plasma concentrations when drug administration is stopped.<\/h2><\/div><\/div>
View Model<\/div><\/a><\/div>\n

See Chapter 11: PK of IV Infusion in a One-Compartment Model
\nTopics relevant to this model are covered in the following sections:<\/h3>\n

\u2013 11.2.3 Simulation Exercise: Part 1 Rate of Infusion and Cpss
\n\u2013 11.2.3 Simulation Exercise: Part 2 Effect of Cl and Vd on Cpss
\n\u2013 11.4.3 Simulation Exercise: Part 3 The Loading Dose
\n\u2013 11.5.2 Simulation Exercise: Part 4 Termination of the Infusion<\/p>\n

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