{"id":25090,"date":"2016-08-15T19:43:59","date_gmt":"2016-08-15T19:43:59","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25090"},"modified":"2019-01-17T15:59:29","modified_gmt":"2019-01-17T20:59:29","slug":"model11","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model11\/","title":{"rendered":"Model 11: Multiple Oral Doses"},"content":{"rendered":"<div class=\"cl-wrapper cl-card-wrapper\"><a class=\"cl-card  \" href=\"https:\/\/exchange.iseesystems.com\/public\/sara-rosenbaum\/multiple-oral-doses-pharmacokinetics\/index.html#page1\" title=\"\"><div class=\"cl-card-container media\"><img decoding=\"async\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1223\/model11-300x199.jpg\" srcset=\"\" alt=\"support\"><\/div><div class=\"cl-card-container text\"><div class=\"cl-card-text\"><h2>Most commonly people take oral doses of a drug over an extended period. This model demonstrates the unique plasma concentration profile associated with this type of drug administration. The model assumes first-order drug absorption with no lag time. Simulations can be carried out to observe how the rate and extent of absorption (bioavailability) affect the profile.<\/h2><\/div><\/div><div class=\"cl-card-container button\">View Model<\/div><\/a><\/div>\n<h4>See Chapter 14: Multiple Oral Doses<br \/>\nTopics relevant to this model are covered in the following sections:<\/h4>\n<p>\u2013 14.4 Simulation Exercise<\/p>\n<p>&nbsp;<\/p>\n<ul class=\"display-posts-listing\"><li class=\"listing-item\"><div class=\"content\"><section class=\"cl-wrapper cl-panel-wrapper\"><div class=\"cl-panel  \"><figure><img decoding=\"async\" src=\"https:\/\/images-na.ssl-images-amazon.com\/images\/I\/51%2BFYUXkqWL._SX348_BO1,204,203,200_.jpg\" srcset=\"\" alt=\"cholab\"><\/figure><article><h1>Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/h1><p><b>By: Sara E. Rosenbaum, Ph.D.<\/B><br \/>\nAn Integrated Textbook with Computer Simulations, which provides a comprehensive  account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p><a class=\"cl-button  \" href=\"https:\/\/www.amazon.com\/Basic-Pharmacokinetics-Pharmacodynamics-Integrated-Simulations\/dp\/1119143152?_encoding=UTF8&amp;ie=UTF8&amp;message=&amp;riskType=expiredCard&amp;successUpdatingPreference=1&amp;updatePaymentsPortalPreferenceSuccess=true\" title=\"\">Purchase from Amazon<\/a><\/p><\/article><\/div><\/section>\n<\/div><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; See Chapter 14: Multiple Oral Doses Topics relevant to this model are covered in the following sections: \u2013 14.4 Simulation Exercise &nbsp;<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25090","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25090"}],"version-history":[{"count":2,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25090\/revisions"}],"predecessor-version":[{"id":37430,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25090\/revisions\/37430"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}