{"id":25092,"date":"2016-08-15T19:44:32","date_gmt":"2016-08-15T19:44:32","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25092"},"modified":"2016-08-15T19:44:32","modified_gmt":"2016-08-15T19:44:32","slug":"model12","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model12\/","title":{"rendered":"Model 12: Nonlinear Pharmacokinetics and Phenytoin"},"content":{"rendered":"
Overview<\/a> Research<\/a> Publications<\/a> iMODR<\/a> SIMS<\/a> Contact<\/a><\/div>\n

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\"model12\"<\/a><\/p>\n

Nonlinear or capacity limited pharmacokinetics can occur whenever a process involved in the absorption, distribution or elimination of a drug becomes saturated. This model demonstrates nonlinear elimination (metabolism) using phenytoin as the model drug. Specifically, it demonstrates how increasing doses of the drug produce disproportionate increases in the plasma concentration. It also demonstrates how the model parameters, Km and Vmax influence of the plasma concentration -time profile.
\nLink to Model<\/a>\n<\/div>\n

See Chapter 15: Nonlinear Pharmacokinetics<\/strong>
\nTopics relevant to this model are covered in the following sections:<\/p>\n

– 15.4.2.1.Simulation Exercise: Effect of Increasing Doses
\n– 15.4.3.1 Simulation Exercise: Influence of Km and Vmax<\/p>\n

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\"Basic<\/a><\/p>\n

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong>
\nBy: Sara E. Rosenbaum
\nPurchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview Research Publications iMODR SIMS Contact Nonlinear or capacity limited pharmacokinetics can occur whenever a process involved in the absorption, distribution or elimination of a drug becomes saturated. This model demonstrates nonlinear elimination (metabolism) using phenytoin as the model drug. Specifically, it demonstrates how increasing doses of the drug produce disproportionate increases in the plasma […]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25092","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25092"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25092\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}