{"id":25100,"date":"2016-08-15T20:05:05","date_gmt":"2016-08-15T20:05:05","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25100"},"modified":"2016-08-15T20:05:05","modified_gmt":"2016-08-15T20:05:05","slug":"model16","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model16\/","title":{"rendered":"Model 16: DDI 4 Time Dependent Inhibition-Paroxetine and Desipramine"},"content":{"rendered":"
Overview<\/a> Research<\/a> Publications<\/a> iMODR<\/a> SIMS<\/a> Contact<\/a><\/div>\n

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\"model16\"<\/a><\/p>\n

This is the fourth in a series of five models on pharmacokinetic-based drug-drug interactions (DDI). It uses the TDI of the metabolism of desimpranine by paroxetine as a background to study the impact of the inhibitor\u2019s KI, kinact and [I], the victim\u2019s fm and the enzymes kdegrad on the plasma concentration, PK parameters and AUCR of the victim drug.
\nLink to Model<\/a>\n<\/div>\n

See Chapter 17: Models Used to Predict DDIs For Orally Administered Drugs<\/strong>
\nTopics relevant to this model are covered in the following sections:<\/p>\n

– 17.4.3 Predictive Models Incorporating Parallel Pathways of Elimination (fm)
\n– 17.4.3.1 AUC and fm
\n– 17.4.3.3 Models For Time-Dependent Inhibitors<\/p>\n

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\"Basic<\/a><\/p>\n

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong>
\nBy: Sara E. Rosenbaum
\nPurchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview Research Publications iMODR SIMS Contact This is the fourth in a series of five models on pharmacokinetic-based drug-drug interactions (DDI). It uses the TDI of the metabolism of desimpranine by paroxetine as a background to study the impact of the inhibitor\u2019s KI, kinact and [I], the victim\u2019s fm and the enzymes kdegrad on the […]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25100","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25100"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25100\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}