{"id":25102,"date":"2016-08-15T20:06:03","date_gmt":"2016-08-15T20:06:03","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25102"},"modified":"2016-08-15T20:06:03","modified_gmt":"2016-08-15T20:06:03","slug":"model17","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model17\/","title":{"rendered":"Model 17: DDI 5 Hepatic and Intestinal Metabolism"},"content":{"rendered":"
Overview<\/a> Research<\/a> Publications<\/a> iMODR<\/a> SIMS<\/a> Contact<\/a><\/div>\n

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\"model17\"<\/a><\/p>\n

The fifth in a series of five models on pharmacokinetic-based drug-drug interactions (DDIs), this model demonstrates the effects of inhibition of both intestinal and hepatic metabolism on the PK of orally administered. It also demonstrates the effect of grapefruit juice on intestinal CYP3A4 and how its effect can be used to estimate Fg.
\nLink to Model<\/a>\n<\/div>\n

See Chapter 17: Models Used to Predict DDIs For Orally Administered Drugs<\/strong>
\nTopics relevant to this model are covered in the following sections:<\/p>\n

– 17.4.4.1 Model for Intestinal Extraction
\n– 17.4.4.2 Combined Hepatic and Intestinal Extraction
\n– 17.4.4.3 Simulation and the Estimation of Fg Using Grapefruit Juice<\/p>\n

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\"Basic<\/a><\/p>\n

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong>
\nBy: Sara E. Rosenbaum
\nPurchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview Research Publications iMODR SIMS Contact The fifth in a series of five models on pharmacokinetic-based drug-drug interactions (DDIs), this model demonstrates the effects of inhibition of both intestinal and hepatic metabolism on the PK of orally administered. It also demonstrates the effect of grapefruit juice on intestinal CYP3A4 and how its effect can be […]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25102","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25102"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25102\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}