{"id":25120,"date":"2016-08-15T20:14:34","date_gmt":"2016-08-15T20:14:34","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25120"},"modified":"2016-08-15T20:14:34","modified_gmt":"2016-08-15T20:14:34","slug":"model26","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model26\/","title":{"rendered":"Model 26: Transit Compartment Model of Drug Response"},"content":{"rendered":"
Overview<\/a> Research<\/a> Publications<\/a> iMODR<\/a> SIMS<\/a> Contact<\/a><\/div>\n

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\"model26\"<\/a><\/p>\n

A delay in response to a drug can occur when it takes a long time for the drug\u2019s initial effect to be translated into the final response (a long transduction process). The delayed response profile can be captured using a series of transit compartments.
\nLink to Model<\/a>\n<\/div>\n

See Chapter 20: Semimechanistic PK-PD Models<\/strong>
\nTopics relevant to this model are covered in the following sections:<\/p>\n

– 20.5 Other Indirect Effect Models
\n– 20.5.1 Transit Compartment
\n– 20.5.1.1 Simulation Exercise<\/p>\n

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\"Basic<\/a><\/p>\n

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong>
\nBy: Sara E. Rosenbaum
\nPurchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview Research Publications iMODR SIMS Contact A delay in response to a drug can occur when it takes a long time for the drug\u2019s initial effect to be translated into the final response (a long transduction process). The delayed response profile can be captured using a series of transit compartments. Link to Model See Chapter […]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25120","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25120"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25120\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}