{"id":25122,"date":"2016-08-15T20:15:09","date_gmt":"2016-08-15T20:15:09","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25122"},"modified":"2016-08-15T20:15:09","modified_gmt":"2016-08-15T20:15:09","slug":"model27","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model27\/","title":{"rendered":"Model 27: Hematological Toxicity of Anticancer Drugs"},"content":{"rendered":"
Overview<\/a> Research<\/a> Publications<\/a> iMODR<\/a> SIMS<\/a> Contact<\/a><\/div>\n

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\"model27\"<\/a><\/p>\n

This model shows the typical effect of several anticancer drugs on the number of circulating neutrophils. The drugs destroy neutrophils as they develop in the bone marrow, and its takes several days for their action to effect the circulating neutrophils. The model demonstrates how inter-individual variability in pharmacokinetics and pharmacodynamics can affect the magnitude and duration of this response.
\nLink to Model<\/a>\n<\/div>\n

See Chapter 20: Semimechanistic PK-PD Models<\/strong>
\nTopics relevant to this model are covered in the following sections:
\n– 20.5 Other Indirect Effect Models
\n– 20.5.2 Model for Hematological Toxicity of Anticancer Drugs
\n– 20.5.2.1 Simulation Model<\/p>\n

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\"Basic<\/a><\/p>\n

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong>
\nBy: Sara E. Rosenbaum
\nPurchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview Research Publications iMODR SIMS Contact This model shows the typical effect of several anticancer drugs on the number of circulating neutrophils. The drugs destroy neutrophils as they develop in the bone marrow, and its takes several days for their action to effect the circulating neutrophils. The model demonstrates how inter-individual variability in pharmacokinetics and […]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25122","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25122"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25122\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}