{"id":25124,"date":"2016-08-15T20:17:08","date_gmt":"2016-08-15T20:17:08","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25124"},"modified":"2016-08-15T20:17:08","modified_gmt":"2016-08-15T20:17:08","slug":"model28","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model28\/","title":{"rendered":"Model 28: Drug Tolerance: Hypothetical Antagonist Model"},"content":{"rendered":"
Overview<\/a> Research<\/a> Publications<\/a> iMODR<\/a> SIMS<\/a> Contact<\/a><\/div>\n

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\"model28\"<\/a><\/p>\n

Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. One model for tolerance assumes that the drug produces a hypothetical metabolite that opposes its action.
\nLink to Model<\/a>\n<\/div>\n

See Chapter 20: Semimechanistic PK-PD Models<\/strong>
\nTopics relevant to this model are covered in the following sections:<\/p>\n

– 20.6 Models of Tolerance
\n– 20.6.1 Introduction to Pharmacologic Tolerance
\n– 20.6.2 Counter-Regulatory Force Tolerance Model
\n– 20.6.2.1 Simulation Exercise<\/p>\n

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\"Basic<\/a><\/p>\n

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong>
\nBy: Sara E. Rosenbaum
\nPurchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview Research Publications iMODR SIMS Contact Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. One model for tolerance assumes that the drug produces a hypothetical metabolite that opposes its action. Link to Model See Chapter 20: Semimechanistic PK-PD Models […]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25124","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25124"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25124\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}