{"id":25126,"date":"2016-08-15T20:19:08","date_gmt":"2016-08-15T20:19:08","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25126"},"modified":"2016-08-15T20:19:08","modified_gmt":"2016-08-15T20:19:08","slug":"model29","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model29\/","title":{"rendered":"Model 29: Tolerance: Precursor Pool Depletion Model"},"content":{"rendered":"<div class=\"sub_nav\"><a title=\"Sara Rosenbaum, Ph.D. \" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\">Overview<\/a> <a title=\"Research Projects\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/research\">Research<\/a> <a title=\"Publications\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/publications\">Publications<\/a> <a title=\"iMODR\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/imodr\">iMODR<\/a> <a title=\"SIMS\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/sims\">SIMS<\/a> <a title=\"Contact\" href=\"https:\/\/web.uri.edu\/pharmacy\/meet\/Sara-Rosenbaum\/\">Contact<\/a><\/div>\n<p><!-- end the main page content loop, now begin the query posts for the category --> <!-- Query posts and list them --><\/p>\n<hr \/>\n<div style=\"clear: left\">\n<p style=\"float: left\"><a href=\"https:\/\/exchange.iseesystems.com\/public\/sara-rosenbaum\/tolerance--precursor-pool-model\/index.html#page1\" rel=\"attachment wp-att-25254\"><img loading=\"lazy\" decoding=\"async\" width=\"256\" height=\"204\" class=\"alignnone size-full wp-image-25254\" style=\"padding-right: 10px\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1223\/model29.jpg\" alt=\"model29\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/model29.jpg 256w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/model29-188x150.jpg 188w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/model29-80x64.jpg 80w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><\/a><\/p>\n<p>Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. Tolerance could occur if an endogenous compound that plays an essential role in the response chain becomes depleted during response. This model assumes the drug stimulates the production of a response variable which becomes then becomes depleted.<br \/>\n<a href=\"https:\/\/exchange.iseesystems.com\/public\/sara-rosenbaum\/tolerance--precursor-pool-model\/index.html#page1\">Link to Model<\/a>\n<\/div>\n<p style=\"clear: both\"><strong>See Chapter 20: Semimechanistic PK-PD Models<\/strong><br \/>\nTopics relevant to this model are covered in the following sections:<\/p>\n<p>&#8211; 20.6 Models of Tolerance<br \/>\n&#8211; 20.6.1 Introduction to Pharmacologic Tolerance<br \/>\n&#8211; 20.6.3 Precursor Pool Model of Tolerance<br \/>\n&#8211; 20.6.3.1 Simulation Exercise<\/p>\n<p style=\"float: left\"><a href=\"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model28\/\">&lt;&lt; Previous<\/a><\/p>\n<p style=\"text-align: right\"><a href=\"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model30\/\">Next &gt;&gt;<\/a><\/p>\n<hr \/>\n<div style=\"clear: left\">\n<p style=\"float: left\"><a href=\"https:\/\/www.amazon.com\/Basic-Pharmacokinetics-Pharmacodynamics-Integrated-Simulations\/dp\/1119143152?_encoding=UTF8&amp;ie=UTF8&amp;message=&amp;riskType=expiredCard&amp;successUpdatingPreference=1&amp;updatePaymentsPortalPreferenceSuccess=true\"><img loading=\"lazy\" decoding=\"async\" style=\"padding-right: 10px\" src=\"https:\/\/images-na.ssl-images-amazon.com\/images\/I\/51%2BFYUXkqWL._SX348_BO1,204,203,200_.jpg\" alt=\"Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition\" width=\"150\" height=\"300\" \/><\/a><\/p>\n<p><strong>Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong><br \/>\nBy: Sara E. Rosenbaum<br \/>\n<a href=\"https:\/\/www.amazon.com\/Basic-Pharmacokinetics-Pharmacodynamics-Integrated-Simulations\/dp\/1119143152?_encoding=UTF8&amp;ie=UTF8&amp;message=&amp;riskType=expiredCard&amp;successUpdatingPreference=1&amp;updatePaymentsPortalPreferenceSuccess=true\">Purchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Overview Research Publications iMODR SIMS Contact Tolerance may be defined as a process that results in a reduction in the response to a specific drug concentration following repeated drug exposure. Tolerance could occur if an endogenous compound that plays an essential role in the response chain becomes depleted during response. This model assumes the drug [&hellip;]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25126","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25126"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25126\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}