{"id":25260,"date":"2016-09-14T17:55:05","date_gmt":"2016-09-14T17:55:05","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25260"},"modified":"2016-09-14T17:55:05","modified_gmt":"2016-09-14T17:55:05","slug":"model31","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model31\/","title":{"rendered":"Model 31: Integrated PK-PD Model For Lipoamide"},"content":{"rendered":"<div class=\"sub_nav\"><a title=\"Sara Rosenbaum, Ph.D. \" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\">Overview<\/a> <a title=\"Research Projects\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/research\">Research<\/a> <a title=\"Publications\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/publications\">Publications<\/a> <a title=\"iMODR\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/imodr\">iMODR<\/a> <a title=\"SIMS\" href=\"https:\/\/web.uri.edu\/pharmacy\/research\/Rosenbaum\/sims\">SIMS<\/a> <a title=\"Contact\" href=\"https:\/\/web.uri.edu\/pharmacy\/meet\/Sara-Rosenbaum\/\">Contact<\/a><\/div>\n<p><!-- end the main page content loop, now begin the query posts for the category --> <!-- Query posts and list them --><\/p>\n<hr \/>\n<div style=\"clear: left\">\n<p style=\"float: left\"><a href=\"https:\/\/exchange.iseesystems.com\/public\/sara-rosenbaum\/integrated-pk-pd-model-for-lipoamide\/index.html\" rel=\"attachment wp-att-25256\"><img loading=\"lazy\" decoding=\"async\" width=\"281\" height=\"225\" class=\"alignnone size-full wp-image-25256\" style=\"padding-right: 10px\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1223\/model31.jpg\" alt=\"model31\" srcset=\"https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/model31.jpg 281w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/model31-187x150.jpg 187w, https:\/\/web.uri.edu\/pharmacy\/wp-content\/uploads\/sites\/1223\/model31-80x64.jpg 80w\" sizes=\"auto, (max-width: 281px) 100vw, 281px\" \/><\/a><\/p>\n<p>Lipoamide is a fictitious antipyretic (fever reducing) drug that is believed to work by reducing the synthesis of cytokines. Based on its mechanism of action and the characteristics of its response, an indirect effect model I (inhibition of kin) was used to model its effect. This model can be used to probe optimum dosing regimens of lipoamide.<br \/>\n<a href=\"https:\/\/exchange.iseesystems.com\/public\/sara-rosenbaum\/integrated-pk-pd-model-for-lipoamide\/index.html\">Link to Model<\/a>\n<\/div>\n<p style=\"clear: both\"><strong>See Chapter 20: Semimechanistic PK-PD Models<\/strong><br \/>\nTopics relevant to this model are covered in the following sections:<\/p>\n<p>&#8211; Problem 20.4<\/p>\n<p style=\"float: left\"><a href=\"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model30\/\">&lt;&lt; Previous<\/a><\/p>\n<p style=\"text-align: right\"><a href=\"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model32\/\">Next &gt;&gt;<\/a><\/p>\n<hr \/>\n<div style=\"clear: left\">\n<p style=\"float: left\"><a href=\"https:\/\/www.amazon.com\/Basic-Pharmacokinetics-Pharmacodynamics-Integrated-Simulations\/dp\/1119143152?_encoding=UTF8&amp;ie=UTF8&amp;message=&amp;riskType=expiredCard&amp;successUpdatingPreference=1&amp;updatePaymentsPortalPreferenceSuccess=true\"><img loading=\"lazy\" decoding=\"async\" style=\"padding-right: 10px\" src=\"https:\/\/images-na.ssl-images-amazon.com\/images\/I\/51%2BFYUXkqWL._SX348_BO1,204,203,200_.jpg\" alt=\"Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition\" width=\"150\" height=\"300\" \/><\/a><\/p>\n<p><strong>Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong><br \/>\nBy: Sara E. Rosenbaum<br \/>\n<a href=\"https:\/\/www.amazon.com\/Basic-Pharmacokinetics-Pharmacodynamics-Integrated-Simulations\/dp\/1119143152?_encoding=UTF8&amp;ie=UTF8&amp;message=&amp;riskType=expiredCard&amp;successUpdatingPreference=1&amp;updatePaymentsPortalPreferenceSuccess=true\">Purchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Overview Research Publications iMODR SIMS Contact Lipoamide is a fictitious antipyretic (fever reducing) drug that is believed to work by reducing the synthesis of cytokines. Based on its mechanism of action and the characteristics of its response, an indirect effect model I (inhibition of kin) was used to model its effect. This model can be [&hellip;]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25260","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25260"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25260\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}