{"id":25262,"date":"2016-09-14T17:55:31","date_gmt":"2016-09-14T17:55:31","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=25262"},"modified":"2016-09-14T17:55:31","modified_gmt":"2016-09-14T17:55:31","slug":"model32","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/sims\/model32\/","title":{"rendered":"Model 32: PBPK Permeability Controlled Model With Transporters"},"content":{"rendered":"
Overview<\/a> Research<\/a> Publications<\/a> iMODR<\/a> SIMS<\/a> Contact<\/a><\/div>\n

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\"model32\"<\/a><\/p>\n

This PBPK model contains a permeability controlled distribution model for the liver and also incorporates an extended clearance model for hepatic elimination, which includes passive diffusion, uptake transporters in the basolateral membrane, metabolism within the hepatocyte and an uptake transporter on the canalicular membrane.
\nLink to Model<\/a>\n<\/div>\n

See Chapter 18: Introduction to PBPK Modeling<\/strong>
\nTopics relevant to this model are covered in the following sections:<\/p>\n

– 18.7.1 Permeability-Limited Distribution
\n– 18.7.2 Drug Transporters<\/p>\n

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\"Basic<\/a><\/p>\n

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition<\/strong>
\nBy: Sara E. Rosenbaum
\nPurchase from Amazon<\/a>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview Research Publications iMODR SIMS Contact This PBPK model contains a permeability controlled distribution model for the liver and also incorporates an extended clearance model for hepatic elimination, which includes passive diffusion, uptake transporters in the basolateral membrane, metabolism within the hepatocyte and an uptake transporter on the canalicular membrane. Link to Model See Chapter […]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":25053,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-25262","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=25262"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25262\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/pages\/25053"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=25262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}