{"id":5230,"date":"2013-08-21T20:27:55","date_gmt":"2013-08-21T20:27:55","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=5230"},"modified":"2019-02-13T13:45:01","modified_gmt":"2019-02-13T18:45:01","slug":"akhlaghi","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/akhlaghi\/","title":{"rendered":"Dr. Fatemeh Akhlaghi – Clinical Pharmacokinetics Research Laboratory"},"content":{"rendered":"

Clinical Pharmacokinetics Research Laboratory<\/h1>

Located in Lab Module 490 on Level 4 of Avedisian Hall<\/p><\/div><\/div>

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Apply site-wide<\/div><\/div><\/div><\/div><\/div><\/div><\/section>

Overview<\/h1><\/p>\n

The Clinical Pharmacokinetics Research Laboratory<\/strong> is specialized in the areas of effect of disease states on drug disposition, pharmacokinetics and pharmacodynamics (PK\/PD) modeling, and therapeutic drug monitoring (TDM). Located at the Kingston Campus of the University of Rhode Island, this laboratory is equipped with High Performance Liquid Chromatography (HPLC-UV, Hitachi) and ABI 3200 LC-Tandem Mass Spectrometry (LC-MS\/MS, AB Sciex), a Xevo\u2122 TQ MS (LC-MS\/MS Waters), and a range of other instruments through RI-INBRE centralized core facility. We have established and validated different analytical methods for determination of immunosuppressive agents (i.e. cyclosporine, tacrolimus, sirolimus and mycophenolic acid) and other medications (listed below). In addition, we specialize in the measurement of free (unbound) drug concentration, either in plasma or oral fluids (saliva), and have established methods for determination of contrast media agents, iohexol or iodixanol, useful for accurate estimation of Glomerular Filtration Rate (GFR).<\/p>\n

Concentration of total drug and metabolites in biological fluids for in vitro metabolism studies<\/strong><\/p>\n