{"id":5233,"date":"2013-08-21T20:29:23","date_gmt":"2013-08-21T20:29:23","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=5233"},"modified":"2025-01-23T11:22:02","modified_gmt":"2025-01-23T16:22:02","slug":"cho","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/cho\/","title":{"rendered":"Dr. Bongsup Cho"},"content":{"rendered":"

Chemical Carcinogenesis Research<\/h1>

Located in Lab Module 450 on Level 4 of Avedisian Hall<\/p><\/div><\/div>

<\/div>
Accessibility controls<\/div>
Pause motion<\/div>
Motion: On<\/span><\/div><\/div>
Play motion<\/div>
Motion: Off<\/span><\/div><\/div><\/div>
Increase text contrast<\/div>
Contrast: Standard<\/span><\/div><\/div>
Reset text contrast<\/div>
Contrast: High<\/span><\/div><\/div><\/div>
<\/div>
Apply site-wide<\/div><\/div><\/div><\/div><\/div><\/div><\/section>

Overview<\/h1><\/p>\n

Our research focuses on chemical carcinogenesis with emphasis on the structural and conformational aspects of DNA-adduct formation. We are interested in how environmental carcinogens, upon metabolism, interact with cellular DNA to initiate mutagenesis\/carcinogenesis.  The long-range goal of our research is to elucidate the mechanisms of mutation and repair at the atomic and molecular-genetic level.   In addition, we recently turned our attention to the emerging contaminants per- and polyfluoroalkyl substances (PFASs) and their interactions with certain essential proteins.<\/p>\n

The animation above illustrates the major conformational motifs of arylamine modified DNA duplexes: modified dG and the complementary dC are shown in cyan and green, respectively, and the carcinogenic moiety is highlighted with red. In the B conformer (far left), anti-[AF]dG maintains Watson\u2212Crick hydrogen bonds, thereby placing the arylamine in the major groove. The arylamine moiety of the S conformer (middle) stacks (base-displaced) into the helix with the modified dG in the syn conformation. The \u2018wedge\u2019 (W) conformation (far right) conformation forces the hydrophobic arylamine to be positioned within the minor groove.                     <\/p>\n

<\/p><\/div><\/section>\n

\n