{"id":5252,"date":"2013-08-21T20:38:53","date_gmt":"2013-08-21T20:38:53","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?page_id=5252"},"modified":"2019-01-24T11:55:14","modified_gmt":"2019-01-24T16:55:14","slug":"rosenbaum","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/pharmacy\/research\/rosenbaum\/","title":{"rendered":"Dr. Sara E. Rosenbaum"},"content":{"rendered":"

Clinical Pharmacokinetics
\nand Pharmacodynamics<\/h1><\/div><\/div>
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Apply site-wide<\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n

Sara Rosenbaum<\/a> is Professor of Pharmacokinetics at the University of Rhode Island and is involved in teaching and research in the broad area of clinical pharmacokinetics and pharmacodynamics. She is interested in applying modeling and simulation of drug response data as tools to more fully understand the time course and intensity of drug effects in man. She is interested in applying these methods in research to obtain a greater understanding of a drug\u2019s properties in different populations. She also develops interactive pharmacokinetic and pharmacodynamic models to demonstrate fundamental drug properties.<\/p>\n

iMODA Simulation Models<\/h1><\/p>\n

Model 1: Introduction to PK, PD, and Dosing<\/a><\/h2>\n

Model 2: Simple Drug Transporter Model<\/a><\/h2>\n

Model 3: Hepatic Clearance Model<\/a><\/h2>\n

Model 4: Single Injection in a 1-Compartment Model<\/a><\/h2>\n

Model 5: Single Injection in a 2-Compartment Model<\/a><\/h2>\n

Model 6: First Order Absorption in a 1-Compartment Model: A Single Oral Dose<\/a><\/h2>\n

Model 7: Constant Continuous Drug Administration<\/a><\/h2>\n

Model 8: Infusion Challenge<\/a><\/h2>\n

Model 9: Multiple Bolus Injections<\/a><\/h2>\n

Model 10: Multiple Intermittent Infusions<\/a><\/h2>\n

Model 11: Multiple Oral Doses<\/a><\/h2>\n

Model 12: Nonlinear Pharmacokinetics and Phenytoin<\/a><\/h2>\n

Model 13: DDI 1 Time Dependent Enzyme Inhibition<\/a><\/h2>\n

Model 14: DDI 2, Enzyme Induction<\/a><\/h2>\n

Model 15: DDI 3, Reversible Inhibition: Fluconazole and Midazolam<\/a><\/h2>\n

Model 16: DDI 4 Time Dependent Inhibition-Paroxetine and Desipramine<\/a><\/h2>\n

Model 17: DDI 5 Hepatic and Intestinal Metabolism<\/a><\/h2>\n

Model 18: Example PBPK Model<\/a><\/h2>\n

Model 19: Drug Response, Sigmoidal Emax Model<\/a><\/h2>\n

Model 20: Pharmacodynamic DDIs<\/a><\/h2>\n

Model 21: Effect Compartment<\/a><\/h2>\n

Model 22: Indirect Effect Compartment Model I<\/a><\/h2>\n

Model 23: Indirect Effect Compartment Model II<\/a><\/h2>\n

Model 24: Indirect Effect Compartment Model III<\/a><\/h2>\n

Model 25: Indirect Effect Compartment Model IV<\/a><\/h2>\n

Model 26: Transit Compartment Model of Drug Response<\/a><\/h2>\n

Model 27: Hematological Toxicity of Anticancer Drugs<\/a><\/h2>\n

Model 28: Drug Tolerance: Hypothetical Antagonist Model<\/a><\/h2>\n

Model 29: Tolerance: Precursor Pool Depletion Model<\/a><\/h2>\n

Model 30: Proton Pump Inhibitors- Model For Irreversible Drug Effects<\/a><\/h2>\n

Model 31: Integrated PK-PD Model For Lipoamide<\/a><\/h2>\n

Model 32: PBPK Permeability Controlled Model With Transporters<\/a><\/h2>\n

Model 33: Operational Model of Agonism<\/a><\/h2>\n

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Research<\/h1><\/p>\n

Sara Rosenbaum is interested in understanding the dose-response relationship through the analysis of a drug’s pharmacokinetic and pharmacodynamic characteristics. She has used NONMEM to create population models and study various patient demographics as potential sources of variability in drug response.  She is also interested in creating integrated pharmacokinetic and pharmacodynamic simulation models to better understand the dose-response relationship. She has created models in almost all therapeutic areas and has more recently  been working in the area of biologics. Some examples of Sara Rosenbaum’s published work is provided below.<\/p>\n