{"id":6607,"date":"2012-01-28T23:20:04","date_gmt":"2012-01-28T23:20:04","guid":{"rendered":"https:\/\/web.uri.edu\/pharmacy\/?p=6607"},"modified":"2012-01-28T23:20:04","modified_gmt":"2012-01-28T23:20:04","slug":"discovering-the-con%ef%ac%81guration-of-cancer","status":"publish","type":"post","link":"https:\/\/web.uri.edu\/pharmacy\/2012\/01\/28\/discovering-the-con%ef%ac%81guration-of-cancer\/","title":{"rendered":"Discovering the Configuration of Cancer"},"content":{"rendered":"

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\nDr Bongsup Cho<\/a> offers an insight into his current research into environmentally-induced cancer, which will expose how aromatic amines mutate DNA and interfere with its repair mechanisms.
\nCould you brie\ufb02y describe your current research project?<\/strong>
\nFormation of aromatic amine-DNA adducts is believed to initiate cancer. We are concerned with elucidating the mechanisms by which amine-DNA lesions are replicated and repaired at both molecular and atomic levels.
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\nWhat are aromatic amines and how do they\u00a0contribute to the development of cancer in humans?<\/strong>
\nAromatic amines belong to a nasty group of\u00a0organic chemicals and have been implicated in the development of bladder, liver, and\u00a0breast cancers in humans. Aromatic amines in their original formulation are not particularly harmful per se, but become chemically reactive electrophiles \u2013 electron de\ufb01 cient – upon metabolic activation in vivo. Some of these electrophiles can react with cellular DNA to form DNA adducts. Such DNA damage is found in human tumour tissue, indicating problems in DNA repair in cells, and is one of the early hallmarks of tumour development.
\nFull text in PDF<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Dr Bongsup Cho offers an insight into his current research into environmentally-induced cancer, which will expose how aromatic amines mutate DNA and interfere with its repair mechanisms. Could you brie\ufb02y describe your current research project? Formation of aromatic amine-DNA adducts is believed to initiate cancer. We are concerned with elucidating the mechanisms by which amine-DNA […]<\/p>\n","protected":false},"author":639,"featured_media":6614,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[161,185,35,77],"tags":[],"class_list":["post-6607","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-bps","category-news-people-cho","category-news","category-news-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/posts\/6607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/comments?post=6607"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/posts\/6607\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media\/6614"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/media?parent=6607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/categories?post=6607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.uri.edu\/pharmacy\/wp-json\/wp\/v2\/tags?post=6607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}