{"id":108,"date":"2022-02-03T08:47:25","date_gmt":"2022-02-03T13:47:25","guid":{"rendered":"https:\/\/web.uri.edu\/riid\/?page_id=108"},"modified":"2022-02-25T12:52:11","modified_gmt":"2022-02-25T17:52:11","slug":"pharmacology","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/riid\/research\/pharmacology\/","title":{"rendered":"Antimicrobial Pharmacology"},"content":{"rendered":"<section class=\"cl-wrapper cl-menu-wrapper\"><nav id=\"\" class=\"cl-menu  \" data-name=\"Main\" data-show-title=\"0\"><ul id=\"menu-main\" class=\"cl-menu-list cl-menu-list-no-js\"><li id=\"menu-item-28\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-28\"><a href=\"https:\/\/web.uri.edu\/riid\/\">Home<\/a><\/li>\n<li id=\"menu-item-283\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-283\"><a href=\"https:\/\/web.uri.edu\/riid\/news-media\/\">News &amp; Media<\/a><\/li>\n<li id=\"menu-item-32\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-32\"><a href=\"https:\/\/web.uri.edu\/riid\/research\/\">Research<\/a><\/li>\n<li id=\"menu-item-29\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29\"><a target=\"_blank\" href=\"https:\/\/web.uri.edu\/antimicrobial-stewardship\/\">Clinical<\/a><\/li>\n<li id=\"menu-item-31\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-31\"><a target=\"_blank\" href=\"https:\/\/www.researchgate.net\/profile\/Kerry-Laplante\">Publications<\/a><\/li>\n<li id=\"menu-item-33\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-33\"><a href=\"https:\/\/web.uri.edu\/riid\/research-team\/\">Research Team<\/a><\/li>\n<li id=\"menu-item-30\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-30\"><a href=\"https:\/\/web.uri.edu\/riid\/fellowship\/\">Fellowship<\/a><\/li>\n<\/ul><\/nav><\/section>\n\n\n\n<h1 class=\"wp-block-heading\"><strong>Antimicrobial<\/strong> Pharmacology<\/h1>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/2101\/klpharm1-1.png\" alt=\"\" class=\"wp-image-253\" width=\"300\" height=\"209\" \/><figcaption><strong>Two compartment in-vitro pharmacodynamic model<\/strong>. This model is used to simulate a patient\u2019s elimination of the drug (t1\/2) and the effects of the antibiotic concentrations and breakdown on antimicrobial activity and resistance development in the presence of a simulated endocarditis vegetation.<\/figcaption><\/figure><\/div>\n\n\n\n<p>Our in-vitro pharmacology research program advances therapy through identifying pharmacodynamic dosing indexes of antimicrobial therapy to optimize activity and prevent resistance development.\u00a0 It is of critical importance to understand the role of drug therapy on bacterial virulence factors such as toxin and biofilm formation. We aim to help close the knowledge gap by identifying novel strategies to combat these virulence factors. Our research has led to new dosing regimens for patients with severe infections. And it is Dr. LaPlante\u2019s mission to further improve patient care by maximizing activity of antibiotic regimens to treat severe infections and prevent patient suffering.\u00a0 She collaborates with an exceptional team of colleagues with leading expertise in biomedical engineering, microscopy, chemistry, and pharmaceutics.<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/2101\/klpharm2-4.png\" alt=\"\" class=\"wp-image-268\" width=\"300\" height=\"215\" \/><figcaption><strong>Catheter-lock model<\/strong>. Used to simulate antibiotic lock therapy in a biofilm infected catheter.<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/2101\/klpharm4-1.png\" alt=\"\" class=\"wp-image-263\" width=\"300\" height=\"215\" \/><figcaption><strong>Staphylococcal biofilm attachment on a medical device<\/strong>. Imaged with a scanning electron microscope by the LaPlante Laboratory.<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/2101\/klpharm5-3.png\" alt=\"\" class=\"wp-image-266\" width=\"300\" height=\"215\" \/><figcaption><strong>One compartment in-vitro pharmacodynamic model<\/strong>. This model is used to simulate a patient\u2019s elimination of the drug (t1\/2) and the effects of antibiotic concentration and breakdown on antimicrobial activity and resistance development.<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"399\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/2101\/klpharm3.jpg\" alt=\"\" class=\"wp-image-218\" srcset=\"https:\/\/web.uri.edu\/riid\/wp-content\/uploads\/sites\/2101\/klpharm3.jpg 300w, https:\/\/web.uri.edu\/riid\/wp-content\/uploads\/sites\/2101\/klpharm3-226x300.jpg 226w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure><\/div>\n\n\n\n<p>Dr. LaPlante\u2019s maintains an extensive collection of several bacteria species including: Methicillin-resistant <em>Staphylococcus aureus<\/em>, Extended spectrum \u03b2-lactamases, Hetero-resistant vancomycin intermediate <em>Staphylococcus aureus<\/em>, vancomycin-resistant <em>enterococci<\/em>, <em>Klebsiella pneumoniae<\/em> carbapenemases, and carbapenem-resistant <em>Acinetobacter baumannii<\/em>. Combining a clinical and scientific career, her laboratory simulates human drug concentrations in multiple infection models (catheter locks, biofilm models etc.) to study the impact of therapy, and virulence on the activity and prevention of drug-resistant bacteria. Additionally, she investigates synergistic activity of adjunctive therapies or last line antibiotics in combination with commonly used antibiotics to help discover novel treatments pathways and prevent resistance rates.<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<a class=\"cl-button   prominent\" href=\"https:\/\/www.researchgate.net\/profile\/Kerry-Laplante\" title=\"\">Research gate publication List<\/a>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antimicrobial Pharmacology Our in-vitro pharmacology research program advances therapy through identifying pharmacodynamic dosing indexes of antimicrobial therapy to optimize activity and prevent resistance development.\u00a0 It is of critical importance to understand the role of drug therapy on bacterial virulence factors such as toxin and biofilm formation. We aim to help close the knowledge gap by [&hellip;]<\/p>\n","protected":false},"author":639,"featured_media":0,"parent":14,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-108","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/pages\/108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/users\/639"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/comments?post=108"}],"version-history":[{"count":5,"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/pages\/108\/revisions"}],"predecessor-version":[{"id":276,"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/pages\/108\/revisions\/276"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/riid\/wp-json\/wp\/v2\/media?parent=108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}