{"id":39,"date":"2013-12-09T13:17:49","date_gmt":"2013-12-09T18:17:49","guid":{"rendered":"https:\/\/web.uri.edu\/inbre-core-facility\/?page_id=39"},"modified":"2025-04-23T15:40:51","modified_gmt":"2025-04-23T19:40:51","slug":"mass-spectrometry","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/mass-spectrometry\/","title":{"rendered":"Mass Spectrometry"},"content":{"rendered":"<div class=\"fullwidth\">\n<section class=\"cl-wrapper cl-menu-wrapper\"><nav id=\"\" class=\"cl-menu  \" data-name=\"Core-Facility-Instruments\" data-show-title=\"0\"><ul id=\"menu-core-facility-instruments\" class=\"cl-menu-list cl-menu-list-no-js\"><li id=\"menu-item-11111\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-11111\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/\">Core Facility<\/a><\/li>\n<li id=\"menu-item-13165\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-13165\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/contact\/\">Contact<\/a><\/li>\n<li id=\"menu-item-35361\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35361\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core_facility_instruments\/\">Instruments<\/a><\/li>\n<li id=\"menu-item-13387\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-13387\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-fees\/\">Reservation and Fees<\/a><\/li>\n<\/ul><\/nav><\/section>\n<section class=\"cl-wrapper cl-menu-wrapper\"><nav id=\"\" class=\"cl-menu  \" data-name=\"CORE_Instruments\" data-show-title=\"0\"><ul id=\"menu-core_instruments\" class=\"cl-menu-list cl-menu-list-no-js\"><li id=\"menu-item-35340\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35340\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/cell-culture\/\">Cell Culture<\/a><\/li>\n<li id=\"menu-item-35334\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35334\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/chromtotography\/\">Chromatography<\/a><\/li>\n<li id=\"menu-item-35335\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35335\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/mass-spectrometry\/\">Mass Spectrometry<\/a><\/li>\n<li id=\"menu-item-35342\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35342\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/spectrometry\/\">Spectrometry<\/a><\/li>\n<li id=\"menu-item-35336\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35336\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/microscopy-imaging\/\">Microscopy &amp; Imaging<\/a><\/li>\n<li id=\"menu-item-36773\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-36773\"><a href=\"https:\/\/web.uri.edu\/riinbre\/single-cell-and-spatial-omics-instruments\/\">Single Cell and Spatial Omics<\/a><\/li>\n<li id=\"menu-item-35341\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35341\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/general-analytical-equipment\/\">General Instruments<\/a><\/li>\n<li id=\"menu-item-35362\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-35362\"><a href=\"https:\/\/web.uri.edu\/riinbre\/core-facility\/instrument-recommendations\/\">Instrument Recommendations<\/a><\/li>\n<\/ul><\/nav><\/section>\n<div class=\"title\">\n<div class=\"title\">\n<h1 class=\"title\"><span style=\"color: #000000;font-family: Lato, Hind, Arial, sans-serif;font-size: 1.3rem;font-weight: bold\">LC\/Mass Spectrometers<\/span><\/h1>\n<div>&nbsp;<\/div>\n<\/div>\n<\/div>\n<div id=\"post-1272\" class=\"post-1272 post type-post status-publish format-standard has-post-thumbnail hentry category-mass-spectrometry\">\n<div class=\"entry\">\n<p><span style=\"font-family: Lato, Hind, Arial, sans-serif;font-size: 1.3rem;font-weight: bold;color: #000000\">AB SCIEX TripleTOF 5600 system<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"post-1272\" class=\"post-1272 post type-post status-publish format-standard has-post-thumbnail hentry category-mass-spectrometry\">\n<div class=\"entry\">\n<div class=\"fullwidth\">\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-31592 alignright\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1497\/AB-SCIEX-TripleTOF-5600-system-300x182.png\" alt=\"\" width=\"300\" height=\"182\"><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"post-1272\" class=\"post-1272 post type-post status-publish format-standard has-post-thumbnail hentry category-mass-spectrometry\">\n<div class=\"entry\">\n<div class=\"fullwidth\">\n<p>The AB SCIEX TripleTOF 5600 system includes a mass spectrometer, a DuoSpray\u2122 ion source, a High frequency LINAC\u00ae Collision Cell, an Accelerator TOF&nbsp;Analyzer, a Detection system, and a computer running the Analyst TF 1.7.1 software. Key features include enhanced selectivity with differential ion mobility, robust spray with the DuoSpray\u2122 Turbo V Source, comprehensive coverage with data-independent SWATH acquisition, and maximize flexibility with front end separations. The AB SCIEX TripleTOF 5600 system is coupled to an Acquity UPLC H-Class system for chromatographic separation.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"fullwidth\">\n<div id=\"post-1272\" class=\"post-1272 post type-post status-publish format-standard has-post-thumbnail hentry category-mass-spectrometry\">\n<div class=\"entry\">\n<h3>&nbsp;<\/h3>\n<div class=\"title\">\n<h3>Elemental Analyzer (ICP-MS) <img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-31660\" src=\"https:\/\/web.uri.edu\/wp-content\/uploads\/sites\/1497\/Elemental-Analyzer_ICP-MS.jpg\" alt=\"\" width=\"200\" height=\"231\"><\/h3>\n<\/div>\n<div id=\"post-290\" class=\"post-290 post type-post status-publish format-standard has-post-thumbnail hentry category-mass-spectrometry\">\n<div class=\"entry\">\n<p>The iCAP Q ICP-MS has been developed with groundbreaking technology to enable advanced high-performance analysis combined with total reliability and ultra-flexibility.<\/p>\n<ul>\n<li>Ergonomically designed quadrupole ICP-MS with smallest bench space available<\/li>\n<li>Innovative RAPID (Right Angle Positive Ion Deflection) lens technology (90\u00b0 ion optics done right) for separation of ions and neutrals<\/li>\n<li>High-performance quadrupole analyzer is pumped by a novel split flow turbo pump backed by a single rotary<\/li>\n<li>New, simultaneous analog\/PC detector with real time multi-channel analyzer&nbsp; electronics provides &gt;9 orders of dynamic range suitable for both steady state and transient signal analysis<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<div class=\"fullwidth\">\n<p><span style=\"font-family: Lato, Hind, Arial, sans-serif;font-size: 1.3rem;font-weight: bold\">MALDI TOF\/TOF Mass Spectrometer<img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-37411 alignright\" src=\"https:\/\/web.uri.edu\/riinbre\/wp-content\/uploads\/sites\/1497\/qn50420000005ow5-e1745425213607.jpg\" alt=\"\" width=\"199\" height=\"343\" srcset=\"https:\/\/web.uri.edu\/riinbre\/wp-content\/uploads\/sites\/1497\/qn50420000005ow5-e1745425213607.jpg 199w, https:\/\/web.uri.edu\/riinbre\/wp-content\/uploads\/sites\/1497\/qn50420000005ow5-e1745425213607-174x300.jpg 174w\" sizes=\"auto, (max-width: 199px) 100vw, 199px\" \/><br \/>\n<\/span>The AXIMA Performance is a MALDI-TOF\/TOF instrument with a 50Hz nitrogen laser, up to 384 sample target capability and automated software.&nbsp; With the ability to perform high energy collisional-induced dissociation (CID), the instrument can provide highly informative MS\/MS spectra for a variety of compounds including peptides, sugars, lipids, small molecules, etc. This instrument provides high sensitivity and resolution using the curved field reflectron for MS\/MS without re-acceleration.<\/p>\n<div class=\"title\">\n<div id=\"post-1272\" class=\"post-1272 post type-post status-publish format-standard has-post-thumbnail hentry category-mass-spectrometry\">\n<div class=\"entry\">\n<div class=\"title\">\n<h3>&nbsp;<\/h3>\n<h3>&nbsp;<\/h3>\n<h3>&nbsp;<\/h3>\n<h3>&nbsp;<\/h3>\n<h3><span style=\"font-family: Lato, Hind, Arial, sans-serif;font-size: 1.3rem;font-weight: bold\">Thermo Scientific Orbitrap Exploris 240 with <span style=\"color: #ff0000\">Microflow<\/span> LC\/MS System<img loading=\"lazy\" decoding=\"async\" class=\" wp-image-35414 alignright\" src=\"https:\/\/web.uri.edu\/riinbre\/wp-content\/uploads\/sites\/1497\/ORbitrap-240.jpeg\" alt=\"\" width=\"281\" height=\"308\"><br \/>\n<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>The Thermo Scientific Orbitrap Exploris 240 LC\/MS System showcases exceptional prowess in distinguishing target ions amidst complex sample interferences, delivering an impressive resolution of up to 240,000 (FWHM) at m\/z 200. Expanding its capabilities further, the inclusion of the Thermo Scientific BioPharma option enables the analysis of large molecules reaching up to m\/z 8000 (accessible upon request). Meanwhile, the Vanquish Flex LC system presents a broad flow rate spectrum, ranging from a minimum of 1 micro liter per minute to a maximum of 8 milliliters per minute, ensuring adaptability across diverse chromatographic requirements.&nbsp;<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<div class=\"title\">\n<div id=\"post-1272\" class=\"post-1272 post type-post status-publish format-standard has-post-thumbnail hentry category-mass-spectrometry\">\n<div class=\"entry\">\n<div class=\"title\">\n<h3><span style=\"font-family: Lato, Hind, Arial, sans-serif;font-size: 1.3rem;font-weight: bold\">Thermo Scientific Orbitrap Exploris 240 with<span style=\"color: #ff0000\"> Nanoflow<\/span> LC\/MS System<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-37414 alignright\" src=\"https:\/\/web.uri.edu\/riinbre\/wp-content\/uploads\/sites\/1497\/IMG_0534-scaled.jpg\" alt=\"\" width=\"332\" height=\"278\"><br \/>\n<\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>To meet the increasing demand for high-sensitivity applications, we have expanded our capabilities by adding another Orbitrap Exploris 240 system, configured for <span style=\"color: #ff0000\">nanoflow<\/span> LC-MS, operating at flow rates between 50 and 500 nL\/min. This setup provides enhanced sensitivity, which is ideal for low-volume applications such as proteomics and metabolomics.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h3><span style=\"font-family: Lato, Hind, Arial, sans-serif;font-size: 1.3rem;font-weight: bold\">Agilent 6470B Triple Quadrupole LC\/MS System<img loading=\"lazy\" decoding=\"async\" class=\" wp-image-35415 alignright\" src=\"https:\/\/web.uri.edu\/riinbre\/wp-content\/uploads\/sites\/1497\/Agilent-6470-300x300.jpg\" alt=\"\" width=\"309\" height=\"332\"><\/span><\/h3>\n<p>The Agilent 6470B LC\/MS with Agilent Jet Stream Source is a sophisticated instrument engineered for comprehensive molecule detection, precise identification, and accurate quantification within intricate sample matrices. Renowned for its exceptional sensitivity and selectivity, this system integrates advanced capabilities, allowing for the analysis of multiple reaction monitoring (MRM) transitions. Key features: VacShield dramatically reduces maintenance by 92% for this instrument, by allowing the user to easily remove the Ion Injector without venting the MS system.&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Shimadzu QP2020 NX Single Quadrupole GCMS<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-37416 alignright\" src=\"https:\/\/web.uri.edu\/riinbre\/wp-content\/uploads\/sites\/1497\/gcms.jpg\" alt=\"\" width=\"312\" height=\"259\"> <\/strong><\/p>\n<p>It is the only GCMS in the URI College of Pharmacy equipped with a chemical ionization (CI) source for analyzing halogenated compounds. This instrument will significantly benefit researchers studying the environmental impacts of brominated or chlorinated organics, which are often identified as carcinogens and endocrine-disrupting agents.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>LC\/Mass Spectrometers &nbsp; AB SCIEX TripleTOF 5600 system The AB SCIEX TripleTOF 5600 system includes a mass spectrometer, a DuoSpray\u2122 ion source, a High frequency LINAC\u00ae Collision Cell, an Accelerator TOF&nbsp;Analyzer, a Detection system, and a computer running the Analyst TF 1.7.1 software. Key features include enhanced selectivity with differential ion mobility, robust spray with [&hellip;]<\/p>\n","protected":false},"author":4688,"featured_media":0,"parent":1598,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-39","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/users\/4688"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":7,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":37417,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/39\/revisions\/37417"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/1598"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}