{"id":4759,"date":"2014-06-03T09:46:09","date_gmt":"2014-06-03T13:46:09","guid":{"rendered":"https:\/\/web.uri.edu\/inbre\/?page_id=4759"},"modified":"2014-06-03T09:46:09","modified_gmt":"2014-06-03T13:46:09","slug":"bloom","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/riinbre\/research\/bloom\/","title":{"rendered":"Pathological grooming in the gabrg2 KO mouse model of body dysmorphism disorder"},"content":{"rendered":"<p><strong>Investigator:<\/strong>\u00a0Christopher Bloom, Providence College<\/p>\n<p><strong>Collaborative Mentor:<\/strong>\u00a0Katharine Phillips, Brown University &amp; Rhode Island Hospital<\/p>\n<p><strong>Scientific Theme:\u00a0<\/strong>Neuroscience<\/p>\n<p style=\"text-align: justify\"><strong>Abstract:<\/strong>\u00a0This project proposes a new animal model of body dysmorphic disorder (BDD). BDD is characterized by\u00a0preoccupation with perceived slight or imagined physical flaws, the effects of which can be debilitating. The\u00a0mental health and social functioning measures in individuals with BDD are worse than both the general\u00a0population and a comparative sample of individuals with diagnoses of clinical depression. Additionally, 25%\u00a0of individuals with BDD have attempted suicide and that an overwhelming majority (80%) reported past or\u00a0current suicidal ideation. Previous work reports a significant enrichment in a mutation in the gabrg2 gene,\u00a0localized on the human Chromosome 5q in people diagnosed with BDD. Using gabrg2 null mice, we propose\u00a0to test the impact of gene deletion on the expression of grooming behavior in mice. This project has the\u00a0potential to develop the first animal model of BDD. Development of such a model will be a critical\u00a0translational tool for understanding the neurobiological basis of this devastating disorder. This model will\u00a0provide: 1) a substrate for testing specific hypotheses regarding the role of the gabrg2 gene on pathological\u00a0behavior, 2) the impact of these manipulations on broader gene expression patterns, 3) its impact on\u00a0neurodevelopment, and 4) a method for screening compounds to treat this often-disabling disorder.<\/p>\n<p style=\"text-align: justify\"><strong>Human Health Relevance:\u00a0<\/strong>Body dysmorphic disorder is characterized by preoccupation with perceived slight or imagined physical\u00a0flaws, the effects of which can be debilitating. The proposed project develops a translational model to\u00a0investigate the underlying neurobiological, environmental and genetic antecedents to this poorly understood\u00a0disorder.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigator:\u00a0Christopher Bloom, Providence College Collaborative Mentor:\u00a0Katharine Phillips, Brown University &amp; Rhode Island Hospital Scientific Theme:\u00a0Neuroscience Abstract:\u00a0This project proposes a new animal model of body dysmorphic disorder (BDD). BDD is characterized by\u00a0preoccupation with perceived slight or imagined physical flaws, the effects of which can be debilitating. The\u00a0mental health and social functioning measures in individuals with BDD [&hellip;]<\/p>\n","protected":false},"author":1036,"featured_media":0,"parent":40,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-4759","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/4759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/users\/1036"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/comments?post=4759"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/4759\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/40"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/media?parent=4759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}