{"id":4812,"date":"2014-06-03T09:28:07","date_gmt":"2014-06-03T13:28:07","guid":{"rendered":"https:\/\/web.uri.edu\/inbre\/?page_id=4812"},"modified":"2014-06-03T09:28:07","modified_gmt":"2014-06-03T13:28:07","slug":"kiesewetter","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/riinbre\/research\/ecd\/kiesewetter\/","title":{"rendered":"Synthetic polymers derived from nature: Materials for disease treatment via organocatalytic ring-opening polymerization"},"content":{"rendered":"<p><strong>Investigator:<\/strong>\u00a0Matthew Kiesewetter, University of Rhode Island<\/p>\n<p><strong>Mentor:<\/strong>\u00a0Geoffrey Bothun, University of Rhode Island<\/p>\n<p><strong>Scientific Theme:\u00a0<\/strong>Cancer<\/p>\n<p style=\"text-align: justify\"><strong>Abstract:<\/strong>\u00a0Multi-drug resistance represents a major hurdle in disease treatment. While some polymeric approaches\u00a0aimed at overcoming multi-drug resistance have shown promise, they are largely based on synthetically\u00a0costly procedures or materials that cannot be metabolized to benign products in vivo. Further, the FDA\u00a0approval of polymers for cancer treatment modalities can represent a major hurdle to the clinical\u00a0implementation of drug delivery polymers. By simply implementing polymer backbones that are composed\u00a0of natural repeat units, one can obviate the requisite approval pathways and facilitate the rapid movement of\u00a0the best treatment options from the laboratory to the clinic. Accordingly, the proposed research will develop\u00a0a new class of highly functionalized polymers for use in drug delivery applications \u2013 built entirely from\u00a0monomer units derived from nature. These constructs will be built with organocatalytic polymerization\u00a0chemistry from hightly functionalized (Aim 1) thiocarbamate and (Aim 2) disulfide monomers. The constructs\u00a0are composed of natural repeat units and will be biodegradable; they are designed to exhibit (Aim 1)\u00a0attenuated release and (Aim 2) bolus release of therapeautic. The rate of release of drug will be evaluated\u00a0with established fluorescence studies and cell uptake and release studies.<\/p>\n<p style=\"text-align: justify\"><strong>Human Health Relevance:\u00a0<\/strong>Overcoming multi-drug resistance is a major hurdle in the treatment of cancer. Polymer-supported methods\u00a0of drug delivery are one method to counteract this problem, but most of these polymers have long or even\u00a0unlimited residence time in the body. This proposal seeks to develop methods to make polymers that are\u00a0fully biocompatible. The polymers will be constructed of building blocks found in nature.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigator:\u00a0Matthew Kiesewetter, University of Rhode Island Mentor:\u00a0Geoffrey Bothun, University of Rhode Island Scientific Theme:\u00a0Cancer Abstract:\u00a0Multi-drug resistance represents a major hurdle in disease treatment. While some polymeric approaches\u00a0aimed at overcoming multi-drug resistance have shown promise, they are largely based on synthetically\u00a0costly procedures or materials that cannot be metabolized to benign products in vivo. Further, the FDA\u00a0approval [&hellip;]<\/p>\n","protected":false},"author":1036,"featured_media":0,"parent":10203,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-4812","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/4812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/users\/1036"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/comments?post=4812"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/4812\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/10203"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/media?parent=4812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}