{"id":4893,"date":"2015-05-01T09:48:05","date_gmt":"2015-05-01T13:48:05","guid":{"rendered":"https:\/\/web.uri.edu\/inbre\/?page_id=4893"},"modified":"2015-05-01T09:48:05","modified_gmt":"2015-05-01T13:48:05","slug":"leung","status":"publish","type":"page","link":"https:\/\/web.uri.edu\/riinbre\/research\/surf-training-award\/leung\/","title":{"rendered":"DNA-binding transition metal complexes with phosphonium-containing ligands"},"content":{"rendered":"<p><strong>Investigator:<\/strong> Chin Hin Leung, Rhode Island College<\/p>\n<p><strong>Scientific Theme:<\/strong> Molecular Toxicology &amp; Cancer<\/p>\n<p style=\"text-align: justify\"><strong>Abstract:\u00a0<\/strong>The proposed research will synthesize a new family of metal complexes with incorporated phosphonium\u00a0groups. The new compounds are expected to shed light on the synergistic effects of tumor-cell selective\u00a0phosphonium groups and DNA-binding metal complexes. Two subtypes of the novel motif will be made, the\u00a0first type based on the square-planar platinum center as found in the FDA approved cancer drugs cisplatin,\u00a0carboplatin and oxaliplatin, with an added phosphonium group linked to the complex through the chelating\u00a0diamine ligand. The second subtype is based on a DNA intercalating palladium compound, in which a\u00a0phosphonium group is attached to the planar heterocyclic ligand. Upon synthesis and characterization, DNA\u00a0binding studies will be performed to evaluate the effects of the added phosphonium groups. The studies will\u00a0shed light on the incorporation of phosphonium groups as a strategy to enhance the cellular uptake and\u00a0overcome resistance in platinum and other precious-metal based anticancer compounds.<\/p>\n<p style=\"text-align: justify\"><strong>Human Health Relevance:<\/strong>\u00a0The proposed research will contribute to further understanding of platinum-based anticancer drugs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigator: Chin Hin Leung, Rhode Island College Scientific Theme: Molecular Toxicology &amp; Cancer Abstract:\u00a0The proposed research will synthesize a new family of metal complexes with incorporated phosphonium\u00a0groups. The new compounds are expected to shed light on the synergistic effects of tumor-cell selective\u00a0phosphonium groups and DNA-binding metal complexes. Two subtypes of the novel motif will be [&hellip;]<\/p>\n","protected":false},"author":1036,"featured_media":0,"parent":10206,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-twocol.php","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-4893","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/4893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/users\/1036"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/comments?post=4893"}],"version-history":[{"count":0,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/4893\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/pages\/10206"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/media?parent=4893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}