{"id":32598,"date":"2022-07-13T13:04:49","date_gmt":"2022-07-13T17:04:49","guid":{"rendered":"https:\/\/web.uri.edu\/riinbre\/?p=32598"},"modified":"2022-07-13T13:12:14","modified_gmt":"2022-07-13T17:12:14","slug":"research-archives-pilot-projects","status":"publish","type":"post","link":"https:\/\/web.uri.edu\/riinbre\/research-archives-pilot-projects\/","title":{"rendered":"Research Archives Pilot Projects"},"content":{"rendered":"

RI-INBRE (2004 – 2017)<\/strong><\/span><\/h3>\n

Pilot Projects<\/strong><\/p>\n

\n

Use of Targeted Nanometer-Size Materials to Increase the Effectiveness of Radiation on Cancer<\/a> 
\nInvestigator: Michael Antosh, University of Rhode Island<\/p>\n

Effects of Early Life Stress on Neurobehavioral Development<\/a> 
\nInvestigator: Kevin Bath, Brown University<\/p>\n

Discovery of anti-cancer leads from cyanobacteria blooms utilizing an MS\/MS-based chemical profiling strategy<\/a> 
\nInvestigator: Matthew Bertin, University of Rhode Island<\/p>\n

Role of mutant Swi\/Snf complexes and their interactors in regulation of differential gene expression in disease
\nInvestigator: Arnob Dutta, University of Rhode Island<\/p>\n

Peroxisome proliferator-activated receptor-alpha (PPAR\u03b1) as a targeted therapy for treatment of bile acid toxicity in cholestatic liver diseases<\/a>                                 
\nInvestigator: Nisanne Ghonem, University of Rhode Island<\/p>\n

Near infrared sensors for assaying the permeability and resultant chemotherapeutic drug delivery efficacy in tumor spheroid models<\/a> 
\nInvestigator: Daniel Roxbury, University of Rhode Island<\/p>\n

Metamaterials-based Near-field Enhanced Biosensing for Early Detection of Lung Cancer
\nInvestigator: Yi Zheng, University of Rhode Island<\/p>\n

Mechanisms of Treprostinil-Mediated Anti-Inflammation in Liver Diseases (2015)
\nInvestigator: Nissane Ghonem, University of Rhode Island<\/p>\n

Nervous System Wiring by the Robo3 Axon Guidance Receptor and its Ligand Nell2 (2015)
\nInvestigator: Alexander Jaworski, Brown University<\/p>\n

Studying Cortico-Muscular Coherence: Fusing Neuroimaging With Body Motion (2015)
\nInvestigator: Kunai Mankodiya, University of Rhode Island<\/p>\n

A Mechanistic Dissection of Transcription-Coupled DNA Repair (2014-2015)
\nInvestigator: Alexandra Deaconescu, Brown University
\nMentor: Rebecca Page, Brown University<\/p>\n

Defining the Role of the Cell Adhesion Molecule TAG-1 in Motor Circuit Formation (2014-2015)
\nInvestigator: Alexander Jaworski, Brown University
\nMentor: Diane Lipscombe, Brown University<\/p>\n

Biomaterials for Sequenced Biomolecular Delivery in Cancer Immunotherapy (2014-2015)
\nInvestigator: Stephen Kennedy, University of Rhode Island
\nMentor: Niall Howlett, University of Rhode Island<\/p>\n

Chemical Biology of DNA Repair, Cellular Metabolism, and Cancer (2014-2015)
\nInvestigator: Deyu Li, University of Rhode Island
\nMentor: Bingfang Yan, University of Rhode Island<\/p>\n

fNIRS-EEG Neuroimaging for Mapping Cortical Activations in PD Patients (2014-2015)
\nInvestigator: Kunal Mankodiya, University of Rhode Island
\nMentors: Walter Besio, University of Rhode Island and Lars Wahlberg, NsGene Inc. and Rhode Island Hospital<\/p>\n

Investigations of the Anti-Leukemia Activity of Natural Product Penisimplicissin (2014-2015)
\nInvestigator: Lynnie Trzoss, University of Rhode Island
\nMentor: David Rowley, University of Rhode Island<\/p>\n

Classification and Functional Characterization of the PP1-Binding Proteins (2014-2015)
\nInvestigator: Ying Zhang, University of Rhode Island
\nMentor: Rebecca Page, Brown University<\/p>\n

A Quantitative Proteomics Approach to Understanding the Sigma-1 Receptor Signaling Pathways (2008-2009)
\nInvestigator: Carthene Bazemore-Walker, Brown University
\nMentor: Wayne Bowen, Brown University<\/p>\n

Exploring Nucleocytoplasmic Shuttling of Metabolic Enzymes (2006-2007)
\nInvestigator: Alexander Brodsky, Brown University
\nMentor: Stephen L. Helfand, Brown University<\/p>\n

Relating Biomembrane Disruption to the Potential Toxicity of Synthetic Inorganic Nanoparticles (2007-2008)
\nInvestigator: Geoffrey Bothun, University of Rhode Island
\nMentor: Arijit Bose, University of Rhode Island<\/p>\n

Synthesis of Next-Generation Inhibitors of Botulinum Neurotoxin (2008-2009)
\nInvestigator: Brenton DeBoef, University of Rhode Island
\nMentor: William Euler, University of Rhode Island<\/p>\n

Total Synthesis of UCS1025A and Derivatives Thereof for Use as Anti-Telomerase Agents (2005-2006)
\nInvestigator: Brenton DeBoef, University of Rhode Island
\nMentor: William Euler, University of Rhode Island<\/p>\n

Genetic Properties of DNA Damage Induced by Peroxynitrite (2008-2009)
\nInvestigator: Sarah Delaney, Brown University
\nMentor: Anatoly Zhitkovich, Brown University<\/p>\n

Mutagenesis and Toxicity of Peroxynitrite-Induced DNA Lesions in Human Cells (2007-2008)
\nInvestigator: Sarah Delaney, Brown University
\nMentor: Anatoly Zhitkovich, Brown University<\/p>\n

Transcriptional Regulation of Bile Salt Export Pump (2006-2007)
\nInvestigator: Ruitang Deng, University of Rhode Island
\nMentor: Bingfang Yan, University of Rhode Island<\/p>\n

Transcriptional Regulation of Bile Salt Export Pump by Endobiotics and Xenobiotics (2005-2006)
\nInvestigator: Ruitang Deng, University of Rhode Island
\nMentor: Bingfang Yan, University of Rhode Island<\/p>\n

Toxicological Significance of Bile Export Pump (2004-2005)
\nInvestigator: Ruitang Deng, University of Rhode Island
\nMentor: Bingfang Yan, University of Rhode Island<\/p>\n

Mechanisms for Estrogen-Mediated Transrepression of Human Bile Salt Export Pump (2008-2009)
\nInvestigator: Ruitang Deng, University of Rhode Island
\nMentor: Bingfang Yan, University of Rhode Island<\/p>\n

Dissecting the Gene Regulatory Network for Epidermis (2008-2009)
\nInvestigator: Steven Irvine, University of Rhode Island
\nMentor: David Nelson, University of Rhode Island<\/p>\n

Dissecting Regulation of Intracellular Vesicle Trafficking in a Tick Salivary Gland Model (2006-2007)
\nInvestigator: Shahid Karim, University of Rhode Island
\nMentors: Thomas N. Mather, University of Rhode Island and Gary Wessel, Brown University<\/p>\n

Fragile Polymer Backbones for Disease Treatment Materials: Organocatalytic Ring-Opening Polymerization of Thioesters (2013-2014)
\nInvestigator: Matthew Kiesewetter, University of Rhode Island
\nMentors: Geoffrey Bothun, University of Rhode Island and Gary Wessel, Brown University<\/p>\n

Estrogen Sulfotransferase and Estradiol Homeostasis in Mammary Epithelial Cells (2005-2006)
\nInvestigator: Roberta King, University of Rhode Island
\nMentors: Bongsup Cho, University of Rhode Island and Bingfang Yan, University of Rhode Island<\/p>\n

Estrogen Sulfotransferase Inhibition and Breast Cancer (2004-2005)
\nInvestigator: Roberta King, University of Rhode Island
\nMentors: Bongsup Cho, University of Rhode Island and Bingfang Yan, University of Rhode Island<\/p>\n

The Effects of Early Embryonic Exposure to PCBs on the Developing Nervous System (2007-2008)
\nInvestigator: Jill Kreiling, Brown University
\nMentor: Surendra Sharma, Brown University<\/p>\n

Development of a New Class of Antibiotics (2005-2006)
\nInvestigator: Thilo Lange, Brown University
\nMentor: Susan Gerbi, Brown University<\/p>\n

The Causes and Consequences of Genomic Change in Parasitic Oomycetes (2010-2011)
\nInvestigator: Christopher Lane, University of Rhode Island
\nMentor: David Nelson, University of Rhode Island<\/p>\n

Evaluating Alpha Toxin and Biofilm Formation in Staphylococcus aureus<\/em> Through the Accessory Gene Regulator Operon (agr) (2006-2007)
\nInvestigator: Kerry LaPlante, University of Rhode Island
\nMentor: David Rowley, University of Rhode Island<\/p>\n

Antimicrobial Agents that Inhibit Alpha-Toxin, Prevent Biofilm Formation in Staphylococcus aureus (2005-2006)
\nInvestigator: Kerry LaPlante, University of Rhode Island
\nMentor: David Rowley, University of Rhode Island<\/p>\n

Establishing Sub-nuclear Domains of Coordinate Gene Regulation (2010-2011)
\nInvestigator: Erica Larschan, Brown University
\nMentor: Stephen Helfand, Brown University<\/p>\n

Profile of miRNA Expression Alterations by Endocrine Disrupting Toxicants (2007-2008)
\nInvestigator: Carmen Marsit, Brown University
\nMentor: Kim Boekelheide, Brown University<\/p>\n

Tumor-Penetrating Acetalated Dextran Nanoparticles Capable of Tandem Delivery of Radiosensitizing Agents for the Treatment of Lung Cancer (2013-2014)
\nInvestigator: Samantha Meenach, University of Rhode Island
\nMentor: Arijit Bose, University of Rhode Island<\/p>\n

Surface Hsc\/OC.10 Confers a Growth and Survival Advantage to Oval Cells, Cholangiocytes and Hepatocellular Carcinomas (2007-2008)
\nInvestigator: David Mills, Rhode Island Hospital
\nMentor: Douglas Hixson, Brown University<\/p>\n

A Field-Deployable Direct Readout Solution-Based SERS method for the Rapid and Sensitive Detection of Pesticides in Fruits and Vegetables (2008-2009)
\nInvestigator: Radha Narayanan, University of Rhode Island
\nMentor: Chris Brown, University of Rhode Island<\/p>\n

The Dynamic Cellular Localization of TrpM1 (2008-2009)
\nInvestigator: Elena Oancea, Brown University
\nMentor: Julie Kauer, Brown University<\/p>\n

The Effects of Environmental Oxidants on HePTP Structure and MAP Kinase Interaction (2007-2008)
\nInvestigator: Rebecca Page, Brown University
\nMentor: Kristi Wharton, Brown University<\/p>\n

Synthesis of Next-Generation Inhibitors of Botulinum Neurotoxin (2008-2009)
\nInvestigator: Becky Sartini, University of Rhode Island
\nMentor: Gary Wessel, Brown University<\/p>\n

Anti-Inflamatory Effects of Strawberry Polyphenols via Sub-Cellular Signaling Pathways in COX-2 Expressing Human Colon Cancer Cell Line (HT-29) (2008-2009)
\nInvestigator: Navindra Seeram, University of Rhode Island
\nMentor: Clinton Chichester, University of Rhode Island<\/p>\n

Design of Anticancer Cytotoxins (2004-2005)
\nInvestigator: Yana K. Reshetnyak, University of Rhode Island
\nMentor: Clinton Chichester, University of Rhode Island<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

RI-INBRE (2004 – 2017) Pilot Projects Use of Targeted Nanometer-Size Materials to Increase the Effectiveness of Radiation on Cancer  Investigator: Michael Antosh, University of Rhode Island Effects of Early Life Stress on Neurobehavioral Development  Investigator: Kevin Bath, Brown University Discovery of anti-cancer leads from cyanobacteria blooms utilizing an MS\/MS-based chemical profiling strategy  Investigator: Matthew Bertin, […]<\/p>\n","protected":false},"author":1036,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[556],"tags":[615,748],"class_list":["post-32598","post","type-post","status-publish","format-standard","hentry","category-drpp","tag-drpp","tag-pilot-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts\/32598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/users\/1036"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/comments?post=32598"}],"version-history":[{"count":3,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts\/32598\/revisions"}],"predecessor-version":[{"id":32601,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts\/32598\/revisions\/32601"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/media?parent=32598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/categories?post=32598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/tags?post=32598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}