{"id":5877,"date":"2016-02-09T11:29:04","date_gmt":"2016-02-09T16:29:04","guid":{"rendered":"https:\/\/web.uri.edu\/inbre\/?p=5877"},"modified":"2020-09-23T09:26:00","modified_gmt":"2020-09-23T13:26:00","slug":"studying-cortico-muscular-coherence-fusing-neuroimaging-with-body-motion","status":"publish","type":"post","link":"https:\/\/web.uri.edu\/riinbre\/studying-cortico-muscular-coherence-fusing-neuroimaging-with-body-motion\/","title":{"rendered":"Studying Cortico-Muscular Coherence: Fusing Neuroimaging with Body Motion"},"content":{"rendered":"<p><strong>Investigator:<\/strong> Kunai Mankodiya, University of Rhode Island<\/p>\n<p><strong>Scientific Theme:<\/strong> Neuroscience<\/p>\n<p><strong>Abstract:<\/strong> The proposal aims at establishing an innovative framework to integrate a wearable full-body motion capture suit with a portable neuroimaging based on functional near-infrared spectroscopy (fNIRS). The unified infrastructure will quantify cortico-muscular coherence (CMC) in people with movement disorders. Cortico-muscular coherence (CMC) also known as brain-muscle synchrony that refers to functional coupling between motor (movement) behaviors and cortical activations. For example, the motor disability observed in Parkinson&#8217;s disease has been associated with alterations in brain activities and CMC. Understanding CMC requires conducting neuroimaging of PD patients simultaneously with muscular\/kinematic measurements of<br \/>\nthe limbs. Despite significant advancements such as neuroimaging techniques\u2013\u2013such as functional magnetic resonance imaging, these technologies are not sophisticated enough to investigate CMC especially in PD population. Functional near-infrared spectroscopy (fNIRS) is a portable Neuroimaging technique and can be used in cortical mapping studies when PD patients are in their natural mobile state, performing various fine-to-gross limb movements. Furthermore, by adding full-body motion sensors (consisting of geometric sensors\u2013\u2013accelerometer, gyroscope and magnetometer) to fNIRS neuroimaging, it becomes possible to perform in-depth analysis of CMC in the PD population and to explore functional connectivity between the brain and motor symptoms. The proposed research is categorized into the<br \/>\nfollowing specific aims:<br \/>\nAim 1: Design a unified system for CMC studies.<br \/>\nAim 2: Quantify the correlation between movements and cortical activations through preliminary trials on healthy adult humans (n=8). The proposed infrastructure can provide new perspectives and give rise to new paradigms for the CMC research of PD.<\/p>\n<p><strong>Human Health Relevance:<\/strong> This exploratory research combining development and validation of the device for PD is relevant to public health for two reasons. First, they may provide a proof-of-concept evidence for the existence of disturbance in brain-muscle synchrony in individuals with PD. Secondly, they may demonstrate that quantification of cortico-muscular coherence is a useful measure of PD progression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigator: Kunai Mankodiya, University of Rhode Island Scientific Theme: Neuroscience Abstract: The proposal aims at establishing an innovative framework to integrate a wearable full-body motion capture suit with a portable neuroimaging based on functional near-infrared spectroscopy (fNIRS). The unified infrastructure will quantify cortico-muscular coherence (CMC) in people with movement disorders. Cortico-muscular coherence (CMC) also known [&hellip;]<\/p>\n","protected":false},"author":1036,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[388],"tags":[],"class_list":["post-5877","post","type-post","status-publish","format-standard","hentry","category-pp-2016"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts\/5877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/users\/1036"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/comments?post=5877"}],"version-history":[{"count":1,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts\/5877\/revisions"}],"predecessor-version":[{"id":22627,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/posts\/5877\/revisions\/22627"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/media?parent=5877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/categories?post=5877"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.uri.edu\/riinbre\/wp-json\/wp\/v2\/tags?post=5877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}