\nTime:<\/strong> 11:00-Noon
\nZoom Link: <\/strong>https:\/\/uri-edu.zoom.us\/j\/97145256668<\/a><\/p>\n
This talk will examine the difficult problem of the biological effects of chemical mixtures using a pharmacodynamic approach. I will discuss the effect of mixtures on receptor activation and the implications for downstream responses. PFAS will provide one example.<\/p>\n
Related readings:<\/strong> Talk by Dr. Webster (Boston University) will examine the difficult problem of the biological effects of chemical mixtures using a pharmacodynamic approach. I will discuss the effect of mixtures on receptor activation and the implications for downstream responses. PFAS will provide one example.<\/p>\n","protected":false},"author":1201,"featured_media":17576,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[8],"tags":[],"class_list":["post-17574","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/posts\/17574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/users\/1201"}],"replies":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/comments?post=17574"}],"version-history":[{"count":5,"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/posts\/17574\/revisions"}],"predecessor-version":[{"id":17597,"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/posts\/17574\/revisions\/17597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/media\/17576"}],"wp:attachment":[{"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/media?parent=17574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/categories?post=17574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.uri.edu\/steep\/wp-json\/wp\/v2\/tags?post=17574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/web.uri.edu\/steep\/wp-content\/uploads\/sites\/1022\/Webster-photo-copy-2-rotated.jpeg\")
Dr. Webster<\/strong> is Professor of Environmental Health at Boston University School of Public Health, with degrees from MIT and BU. His expertise is in mixtures toxicology\/ pharmacology, environmental epidemiology, and exposure science. Dr. Webster\u2019s current primary research interests include:
\n1)<\/strong> exposure and health effects of PFAS,
\n2)<\/strong> biological effects of exposure to mixtures from the perspectives of both toxicology and epidemiology. He has previously served on numerous expert panels of the USEPA and the National Academies.<\/p>\n
\n1. Howard GJ, Webster TF. Generalized concentration addition: A method for
\nexamining mixtures containing partial agonists. Journal of Theoretical Biology
\n2009; 259:469\u2013477.
\n2. Nielsen G, Heiger-Bernays WJ, Schlezinger JJ, Webster TF. Predicting the Effects of
\nPer- and Polyfluoroalkyl Substance Mixtures on Peroxisome Proliferator-
\nActivated Receptor Alpha Activity in Vitro. Toxicology 2022; 465: 153024
\n3. Schlezinger JJ, Heiger-Bernays W, Webster TF. Predicting the activation of the
\nandrogen receptor by mixtures of ligands using Generalized Concentration
\nAddition. Toxicol. Sci. 2020;177(2):466-475.<\/p>\n","protected":false},"excerpt":{"rendered":"