Methotrexate (MTX) is a small organic molecule to treat cancer (breast, leukemia, lymphoma) and autoimmune diseases (psoriasis, rheumatoid arthritis, and Crohn’s diseases). This project requires manipulation of MTX structures and active ligand binding. The students will learn the importance of active site binding and geometry for enzyme efficiency, drug action, and drug resistance.
Faculty: Dr. Bongsup Cho
Department: Biomedical and Pharmaceutical Sciences
Students: James Chen, Alex Huang, and Julius Chen