Disseminated Effects in Agent Based Models: A Potential Outcomes Framework and Application to Inform Pre-Exposure Prophylaxis Coverage Levels for HIV Prevention

We developed an agent-based model using a novel trial emulation approach to quantify disseminated effects of PrEP use among men who have sex with men in Atlanta, GA. Components (subsets of agents connected through partnerships in a sexual network, but not sharing sexual partnerships any other agents) were first randomized to an intervention coverage level or control, then within intervention components, eligible agents were randomized to PrEP.

Dissem ABMs AJE Revised Apr 2020 FINAL