Yana Reshetnyak

  • Professor
  • Room 223
  • Phone: 401.874.2060
  • Fax: 401.874.2380
  • Email: reshetnyak@uri.edu
  • Office Location: East Hall, Room 223
    2 Lippitt Rd
    Kingston, RI 02881
  • Website

Biography

2013-present: Professor, Physics Department, University of Rhode Island.

2013-present: Professor Adjunct, Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert Brown Medical School.

2013-present: Commissioner, RI Atomic Commission.

2009-2013: Associate Professor, Physics Department, University of Rhode Island.

2004–2009: Assistant Professor, Physics Department, University of Rhode Island.

Research

Biological physics: membrane biophysics, protein fluorescence spectroscopy and structure, microscopy.

Medical physics and nanotechnology: drug delivery, whole-body fluorescence imaging, cancer nanotechnology.

Education

1993: M.S. in Molecular  Physics,  Diploma  with  distinction,  Physics  Department, St.- Petersburg State University, St.-Petersburg, Russia

2000: Ph.D. in Physics and Mathematics (Biological Physics), Institute of Theoretical & Experimental Biophysics Russian Academy of Sciences, Pushchino, Russia.   (“Relations between Fluorescence Parameters of Tryptophan Residues and the Structural and Physical Characteristics of Microenvironments of Indole Rings in Proteins”)

2000 – 2003:Postdoctoral   Research    Associate;   Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Centre.

2003 – 2004:Postdoctoral   Research   Associate;   Laboratory   of   Prof. Donald Engelman, Department of Molecular Biophysics and Biochemistry, Yale University.

Selected Publications

SELECTED PUBLICATIONS

  • Wyatt LC, Moshnikova A, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK. Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors. Proc Natl Acad Sci U S A.2018 Mar 20;115(12):E2811-E2818.
  • Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, Engelman DM. (2017) Applications of pHLIP Technology for Cancer Imaging and Therapy. Trends Biotechnol. 2017 Jul;35(7):653-664. Review
  • Golijanin J, Amin A, Moshnikova A, Brito JM, Tran TY, Adochite RC, Andreev GO, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D., (2016) Targeted Imaging of Urothelium Carcinoma in Human Bladders by an ICG pHLIP peptide ex vivo., Proc Natl Acad Sci U S A., 113(42), 11829-11834.
  • Anderson M, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA., (2016) Probe for the measurement of cell surface pH in vivo and ex vivo., Proc Natl Acad Sci U S A., 113, 8177-8181.
  • D Weerakkody, A Moshnikova, NS El. Sayed, R-C Adochite, G Slaybaugh, J Golijanin, RK Tiwari, OA Andreev, K Parang, YK Reshetnyak (2016) Novel pH-sensitive cyclic peptides. Scientific Reports., 6:31322.
  • T. Tapmeier, A. Moshnikova, J. Beech, D. Allen, P. Kinchesh, S. Smart, A. Harris, A. McIntyre, D. M. Engelman, O. A. Andreev, Y. K. Reshetnyak, R. J. Muschel (2015) The pH low insertion peptide, pHLIP Var3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A., 112(31), 9710-9715.
  • Antosh, D. D. Wijesinghe, S. Shrestha, R. Lanou, Y. H. Huang, T. Hasselbacher, D. Fox, N. Nerettia, S. Sun, N. Katenka, L. N. Cooper, O. A. Andreev, Y. K. Reshetnyak, (2015) Enhancement of radiation effect on cancer cells by gold-pHLIP, Proc Natl Acad Sci U S A., 112 (17), 5372-5376.
  • A. Andreev, D. M. Engelman, Y.K. Reshetnyak, (2014) Targeting diseased tissues by pHLIP insertion at low cell surface pH, Frontiers in Physiology and Membrane Biophysics,5, article 97, 1-7.
  • Cruz-Monserrate, C. L. Roland, D. Deng, T. Arumugam, A. Moshnikova, O. A. Andreev, Y. K. Reshetnyak, C. D. Logsdon (2014) Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment”, Scientific Reports, 4, 4410, 1-8.
  • Wijesinghe, M. C. Mallawa Arachchige, A. Lu, Y. K. Reshetnyak, O. A. Andreev (2013) Transfer of nano-pores into membrane of cancer cells induces intracellular acidification and apoptosis, Scientific Reports, Vol. 3: 3560, 1-7.
  • Weerakkody, A. Moshnikova, M. S. Thakur, V. Moshnikova, J. Danniels, D. M. Engelman, O. A. Andreev, Y. K. Reshetnyak (2013) A Family of pH (Low) Insertion Peptides for Tumor Targeting  Natl. Acad. Sci U.S.A.,110, 15, 5834-5839.
  • Yao L, J. Daniels, A. Moshnikova, S. Kuznetsov, A Ahmed, D.M. Engelman, Y.K. Reshetnyak, O.A. Andreev (2013) The pHLIP peptide targets nanogold particles to tumors,  Natl. Acad. Sci U.S.A., 110(2), 465-470.
  • Sosunov, E. P. Anyukhovsky, A. A. Sosunov, A. Moshnikova, D. Wijesinghe, D. M. Engelman, Y. K. Reshetnyak, O. A. Andreev, pHLIP targets ischemic myocardim (2013) Proced. Natl. Acad. Sci U.S.A., 110 (1), 82-86.
  • G. Karabadzhak, D. Weerakkody, D. Wijesinghe, M.S. Thakur, D.M. Engelman, O.A. Andreev, V.S. Markin, Y.K. Reshetnyak  (2012) Modulation of the pHLIP Transmembrane Helix Insertion Pathway,  Biophys Journal,  102, 1846-1855.
  • Andreev O.A., A. G. Karabadzhak,  D. Weerakkody,  G. O. Andreev, D. M. Engelman, Y. K. Reshetnyak (2010) The pHLIP peptide inserts across a lipid bilayer as a helix, and exits by a different path,  Natl. Acad. Sci U.S.A., 107 (9), 4081-4086.
  • Reshetnyak  Y.K., O. Andreev, M. Segala,  V. Markin, D. Engelman  (2008) Energetics  of Peptide (pHLIP) binding to and folding across a lipid bilayer membrane ,  Natl. Acad. Sci U.S.A., 105 (40), 15340-15345.
  • Shen, R. Menon, D. Das, N. Bansal, N. Nahar, N. Guduru, S. Jaegle, J. Peckham, Y. K.Reshetnyak (2008) The Protein Fluorescence And Structural Toolkit (PFAST): Database and programs for the analysis of protein fluorescence and structural data. Protein: Structure, Function, and Bioinformatics, 71 (4), 1744-1754.
  • Andreev, A. D. Dupuy, M. Segala, S. Sandugu, D. A. Serra, C. O. Chichester, D. M. Engelman, Y. K. Reshetnyak (2007) Mechanism and Uses of a Peptide that Targets Tumors and other Acidic Tissue In vivo, Proced. Natl. Acad. Sci U.S.A.104 (19) 7893-7898.
  • Reshetnyak, Y. K., Andreev, A., Lehnert, U., & Engelman, D.M. (2006) Translocation of molecules into cells by pH-dependent insertion  of a transmembrane helix. Proced. Natl. Acad. Sci U.S.A. 103 (17), 6460-6465.
  • Reshetnyak  Y.K.,  Yu.  Koshevnik,   and E.A.  Burstein  (2001) Decomposition  of protein tryptophan fluorescence  spectra  into log-normal components:  III. Correlation  between fluorescence and microenvironment parameters of individual tryptophan residues,  J., 81 (3), 1735-1758.
  • Reshetnyak   Y.K.,   and  E.A.   Burstein   (2001) Decomposition   of  protein  tryptophan fluorescence spectra into log-normal components: II. The statistical proof of discreteness of tryptophan classes in proteins,  J., 81 (3), 1710-1734.
  • Burstein  E.A.,  S.M.  Abornev, and Y.K.  Reshetnyak  (2001) Decomposition  of protein tryptophan fluorescence  spectra  into  log-normal components:  I. Algorithm of decomposition,  J., 81 (3), 1699-1709.

AWARDS AND HONORS:

2018: URI Outstanding Inventor
2017: URI Outstanding Inventor
2016: Maitland P. Simmons Memorial Research Award
2015: URI Excellence Award
2014: URI Outstanding Inventor
2013: URI Research Excellence Award
2013: URI Outstanding Inventor
2012: Maitland P. Simmons Memorial Research Award
2012: URI Outstanding Inventor
2011: Maitland P. Simmons Memorial Research Award
2010: URI Outstanding Inventor
2006: URI Outstanding Inventor
2004: NSF Advance Faculty Fellow
2002: Laureate of the Gregorio Weber International Competition
1998: Stefan Batory Foundation grant
1998: Soros PhD-student grant award # a98-1929
1997: Wood/Whelan Fellowship from the International Union of Biochemistry and Molecular Biology
1997: Soros PhD-student grant award # a97-1841

23 Patents and patent applications: