Associate Professor
Office: 228 Morrill Science Bldg.
Telephone: (401) 874-5049
Email: martin@uri.edu

Education
  • 1989 Ph.D in Organic Chemistry, University of California at Los Angeles, CA USA; Dissertation Title: “Synthesis of Small Molecules to Probe Deoxyribonucleic Acid Binding” Martin, Lenore M. , working under Professors Orville L. Chapman & Juli Feigon
  • 1986 C.Phil. Chemistry & Biochemistry, UCLA, Los Angeles, CA USA
  • 1983 B.A. Chemistry & Biochemistry, Northwestern University, Evanston, IL USA
  • 1989-1994 Postdoctoral Fellow, Then Research Associate in Peptide Chemistry & Biology; working under Professor R.B. Merrifield, The Rockefeller University, New York, NY USA
Teaching
  • Introductory Biochemistry & General Biochemistry – BCH311, BCH581, & BCH582
  • Biochemistry Laboratories – BCH312 & BCH412
  • Physical Biochemistry – BCH521
  • Bioinformatics I – MIC522
  • Natural Products & Biotechnological Drugs – BMS445
  • Immunologic Drugs, Antibiotics, & Anticancer Drugs – BMS446
Research Areas

i. Combinatorial Libraries, Antimicrobial Peptide Chemistry, Analytical Biochemistry, Bioinformatics, and Structural Biology.

We investigate the complex interactions between biopolymers (peptides, proteins, DNA, RNA, lipids, and carbohydrates) in order to understand cellular physiology at the molecular level. My research at URI has focused on using solid-phase peptide synthesis (SPPS) to prepare diverse combinatorial libraries of both naturally-occurring and engineered peptides for further study. We have designed antimicrobial peptides (AMPs) based upon pleurocidin, isolated from Winter Flounder, to combat the growing problem of antimicrobial resistance in pathogenic microbes, and topoisomerase inhibitors based on natural products for use in cancer chemotherapy. Our bioanalytical chemistry research has involved the development of novel methods for monitoring dynamic properties of peptides, proteins, lipids and DNA using capillary electrophoresis (CE), circular dichroism (CD), and nuclear magnetic resonance (NMR) spectroscopy. The molecular modeling/bioinformatics research area aims to expand the application of molecular mechanics techniques in order to model dynamic processes in the biopolymers we investigate.

Lab Information
Lab: Morril Science Bldg Rm 224
Phone: (401) 874-9287
Website: martinlab.homeip.net

Students
Postdoctoral Fellows: Vanina Guidi PhD
Graduate Students: Roxanne LaCroix, David Ryder

For student research opportunities contact Prof. Martin for details.

Selected Publications
  • Hu, Bi-Huang; Martin Lenore M. (1999) “Capillary Electrophoresis of Peptides and Proteins” Chapter 4 in High-Resolution Chromatography: A Practical Approach, Millner, P.A. Ed. IRL/Oxford University Press: Oxford; pp. 77-116. ISBN 0-19-963648-6.
  • Martin, Lenore M.; Scovell, William (2003) Student Study Guide & Problems Book for Campbell & Farrell’s Biochemistry 4th ed. Chapters 7-21. Brooks/Cole, Thomson Learning Inc. 454 pages. ISBN 0-03-034917-6.
  • Martin, Lenore M.; Merrifield, R.B. (1992) “Synthesis and Characterization of Immunoglobulin Variable Region Heavy and Light Chain Fragments” In Peptides: Chemistry and Biology; Smith, John A.; Rivier, Jean E. Eds.; ESCOM: Leiden; pp. 849-50.
  • Martin, Lenore M.; Rotondi, Kenneth S; Merrifield, R.B. (1994) “Antibody Binding Constants by Capillary Electrophoresis”, In Peptides: Chemistry and Biology; Hodges, R.; Smith, John A.; Eds.; ESCOM: Leiden; pp. 249-51.
  • Martin, Lenore M.; Rotondi, Kenneth S; Merrifield, R.B. (1994) “McPC603 VH(1-115): Synthesis and Folding of Immunoglobulin Variable Regions”, In Peptides: Chemistry and Biology; Hodges, R.; Smith, John A.; Eds.; ESCOM: Leiden; pp. 745-47.
  • Martin, Lenore M. (1996) “The Use of Ion-Pairing Reagents Improves the Separation of Hydrophobic Peptides by Capillary Electrophoresis” In Peptides: Chemistry, Structure and Biology; Kaumaya, P.T.P.; Hodges, R.; Eds.; Mayflower: England; pp. 144-45.
  • Martin, Lenore M., Hu, Bi-Huang, and Li, Chunze (1998) “Enantiomeric Structural Libraries of Unnatural Peptides Which Bind DNA and Alter Enzymatic Activity” In Peptides: Frontiers of Peptide Science, Tam, J.P. and Kaumaya, P.T.P. eds), Kluwer Academic Publishing: Dordrecht, The Netherlands; pp. 122-23.
  • Martin, Lenore M. (1996) “Antibody Fragment Separations by Capillary Zone Electrophoresis” Journal of Chromatography B. 675: pp. 17-25.
  • Martin, Lenore M. (1996) “Facile Reduction in the Synthesis of Phosphorylcholine Affinity Columns” Tetrahedron Letters, 37(44); pp. 7921-24.
  • Li, Chunze; Martin, Lenore M. (1998) “A Robust Method for Determining DNA Binding Constants Using Capillary Zone Electrophoresis” Analytical Biochemistry. 263; pp. 72-78.
  • Martin, Lenore M. “Design of Biomimetic Peptides for Antibiotic Use” (1999) In Maritimes: Environmental Biotechnology , 41(2) Bradley, T. Ed. URI Office of Marine Programs, Summer 1999; pp. 19-21.
  • Martin, Lenore M. and Hu, Bi-Huang. (1999) “Thiazole and Oxazole Building Blocks for Combinatorial Synthesis” Tetrahedron Letters, 40; pp. 7951-53.
  • Hu, Bi-Huang; Martin, Lenore M. (2000) “Design, Synthesis and Antibacterial Activity of a Peptidomimetic Library” in Peptides for the New Millennium Gregg B. Fields, James P. Tam, and George Barany, eds., Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 746-47.
  • Martin, Lenore M.; Messmer, Bradley; Thaler, David (2000) “Synthetic Peptide Analogs Compared with Phage Display” in Peptides for the New Millennium Gregg B. Fields, James P. Tam, and George Barany, eds., Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 172-73.
  • Martin, Lenore M. Elsaid, Khaled A.; Dorrington, Tarquin; and Gómez-Chiarri, Marta. (2002) “Synthetic Studies on the Antimicrobial Activity of Pleurocidin” in Peptides: The Wave of the Future Houghten, Richard A.; Lebl, Michal; Fields, Gregg B.; and Barany, George eds., Kluwer Academic Publishers, Dordrecht, The Netherlands,pp. 475-476.